ENSDARG00000075437


Danio rerio

Features
Gene ID: ENSDARG00000075437
  
Biological name :shc1
  
Synonyms : shc1 / SHC (Src homology 2 domain containing) transforming protein 1
  
Possible biological names infered from orthology : P29353 / P98083 / SHC adaptor protein 1 / SHC-transforming protein 1
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 22781854
Gene end: 22863603
  
Corresponding Affymetrix probe sets: Dr.12113.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000089171
Ensembl peptide - ENSDARP00000152313
Ensembl peptide - ENSDARP00000123188
NCBI entrez gene - 323818     See in Manteia.
RefSeq - XM_005169755
RefSeq - XM_005169756
swissprot - E9QCZ8
swissprot - E7F3T0
ZFIN ID - ZDB-GENE-030131-2538
Ensembl - ENSDARG00000075437
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SHC1ENSGALG00000039775Gallus gallus
 SHC1ENSG00000160691Homo sapiens
 Shc1ENSMUSG00000042626Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
shc2 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / Q8BMC3* / SHC adaptor protein 2*ENSDARG0000006208054
SHC3 / SHC adaptor protein 3 / Q92529*ENSDARG0000009890937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029586  SHC-transforming protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
DAP12 signaling
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Integrin alphaIIb beta3 signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
SHC-mediated cascade:FGFR1
SHC-mediated cascade:FGFR2
SHC-mediated cascade:FGFR3
SHC-mediated cascade:FGFR4
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
MET activates RAS signaling
RET signaling
Interleukin-15 signaling
Interleukin receptor SHC signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000180 caudal vein caudal vein dilated , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel disorganized , abnormal
intersegmental vessel immature , abnormal
intersegmental vessel lacks all parts of type angiogenic sprout , abnormal
Show

 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017565 itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *  / complex
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / complex
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / reaction
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000015752 zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*  / reaction
 ENSDARG00000006468 grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / reaction / complex
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / reaction / complex
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000042723 gfra2a / GDNF family receptor alpha 2a / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000068763 plcg2 / phospholipase C, gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000044015 gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex
 ENSDARG00000055305 ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...  / complex / reaction
 ENSDARG00000028663 tek / TEK tyrosine kinase, endothelial / Q02763* / TEK receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000076294 klb / klotho beta / Q86Z14* / Q99N32* / Beta-klotho *  / complex / reaction
 ENSDARG00000079849 nrtn / neurturin / P97463* / Q99748*  / reaction / complex
 ENSDARG00000074582 gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000074283 inpp5d / inositol polyphosphate-5-phosphatase D / Q92835* / Q9ES52* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 *  / reaction / complex
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / reaction / complex
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSDARG00000098663 fgf19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / reaction / complex
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction / complex
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / reaction / complex
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / reaction / complex
 ENSDARG00000034610 insb / preproinsulin b / INS* / IGF2* / Ins1* / Ins2* / P01325* / F8WCM5* / P01326* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / ...  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000098477 tec / tec protein tyrosine kinase / P42680*  / complex
 ENSDARG00000007356 fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / complex / reaction
 ENSDARG00000069105 fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction / complex
 ENSDARG00000086070 fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / reaction / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000004433 btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *  / complex / reaction
 ENSDARG00000102778 fgf17 / Q6SJP8 / fibroblast growth factor 17 / O60258* / P63075*  / reaction / complex
 ENSDARG00000101169 grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000027423 igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / reaction / complex
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000004782 fgfr3 / fibroblast growth factor receptor 3 / P22607*  / reaction / complex
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / complex / reaction
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000043962 fgf18b / fibroblast growth factor 18b / FGF18* / O89101* / O76093* / fibroblast growth factor 18*  / reaction / complex
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / reaction / complex
 ENSDARG00000035350 ins / O73727 / preproinsulin / Ins1* / IGF2* / Ins2* / F8WCM5* / P01326* / P01325* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / I...  / reaction / complex
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSDARG00000034434 igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / reaction / complex
 ENSDARG00000011948 insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / reaction / complex
 ENSDARG00000071524 insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000087704 gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*  / reaction / complex
 ENSDARG00000089043 ptpn6 / protein tyrosine phosphatase, non-receptor type 6 / P29350* / P29351*  / complex
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSDARG00000039959 gdnfa / glial cell derived neurotrophic factor a / GDNF* / P39905* / P48540* / glial cell derived neurotrophic factor* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), tra...  / reaction / complex
 ENSDARG00000099841 PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*  / reaction
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction / complex
 ENSDARG00000102525 lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex / reaction






 

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