ENSDARG00000101540


Danio rerio

Features
Gene ID: ENSDARG00000101540
  
Biological name :fgf3
  
Synonyms : fgf3 / fibroblast growth factor 3 / P48802
  
Possible biological names infered from orthology : P11487
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 54605640
Gene end: 54609108
  
Corresponding Affymetrix probe sets: Dr.5775.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000132485
NCBI entrez gene - 30549     See in Manteia.
swissprot - B3DHR1
swissprot - P48802
ZFIN ID - ZDB-GENE-980526-178
Ensembl - ENSDARG00000101540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF3ENSGALG00000026853Gallus gallus
 FGF3ENSG00000186895Homo sapiens
 Fgf3ENSMUSG00000031074Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*ENSDARG0000007651030
fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*ENSDARG0000003093228
fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*ENSDARG0000010047528
fgf16 / Q2HXK8 / fibroblast growth factor 16 / O43320* / Q9ESL8*ENSDARG0000004223326
fgf5 / fibroblast growth factor 5 / P12034* / P15656*ENSDARG0000003537726
fgf7 / fibroblast growth factor 7 / P21781*ENSDARG0000005938725
fgf11b / fibroblast growth factor 11b / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000004390725
fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000008607025
fgf6b / fibroblast growth factor 6b / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000004585625
fgf13b / fibroblast growth factor 13b / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000005663325
fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000000735624
fgf13a / fibroblast growth factor 13a / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000003505623
fgf6a / fibroblast growth factor 6a / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000000935123
fgf11a / fibroblast growth factor 11a / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000006966223
fgf4 / fibroblast growth factor 4 / P08620* / P11403*ENSDARG0000010523023
fgf12a / fibroblast growth factor 12a / FGF12* / P61329* / P61328* / fibroblast growth factor 12*ENSDARG0000002795722
fgf14 / fibroblast growth factor 14 / Q92915*ENSDARG0000004098221
fgf12b / fibroblast growth factor 12b / FGF12* / P61328* / fibroblast growth factor 12*ENSDARG0000011352519
fgf9 / fibroblast growth factor 9ENSDARG0000007862518


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028232  Fibroblast growth factor 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007422 peripheral nervous system development IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0009880 embryonic pattern specification IGI
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0021571 rhombomere 5 development IGI
 biological_processGO:0021572 rhombomere 6 development IGI
 biological_processGO:0021703 locus ceruleus development IGI
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0021985 neurohypophysis development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0030335 positive regulation of cell migration IGI
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0030916 otic vesicle formation IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043049 otic placode formation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0048665 neuron fate specification IGI
 biological_processGO:0048666 neuron development IGI
 biological_processGO:0048702 embryonic neurocranium morphogenesis IGI
 biological_processGO:0048709 oligodendrocyte differentiation IGI
 biological_processGO:0048840 otolith development IGI
 biological_processGO:0048920 posterior lateral line neuromast primordium migration IGI
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060041 retina development in camera-type eye IGI
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IGI
 biological_processGO:0060118 vestibular receptor cell development IMP
 biological_processGO:0071599 otic vesicle development IGI
 biological_processGO:0071696 ectodermal placode development IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IDA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus posterior side has fewer parts of type dopaminergic neuron , abnormal
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 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle agenesis , abnormal
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 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton absent , abnormal
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 ZFA:0000118 hypophysis hypophysis quality , abnormal
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 ZFA:0000138 otic placode otic placode decreased size , abnormal
otic placode physical object quality , abnormal
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 ZFA:0000170 basibranchial basibranchial aplastic , abnormal
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 ZFA:0000217 inner ear inner ear quality , abnormal
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 ZFA:0000386 macula macula fused with macula , abnormal
macula adjacent to macula , abnormal
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 ZFA:0000558 posterior macula posterior macula increased size , abnormal
posterior macula has extra parts of type hair cell , abnormal
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 ZFA:0000559 otolith organ otolith organ decreased amount , abnormal
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 ZFA:0000700 utricle utricle lacks parts or has fewer parts of type hair cell , abnormal
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 ZFA:0001079 blood vasculature blood vasculature lacks all parts of type hypophyseal artery , abnormal
blood vasculature lacks all parts of type hypophyseal capillary , abnormal
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 ZFA:0001114 head head lacks all parts of type glossopharyngeal ganglion , abnormal
head lacks all parts of type vagal ganglion 1 , abnormal
head lacks all parts of type vagal ganglion 2 , abnormal
head lacks all parts of type vagal ganglion 3 , abnormal
head lacks all parts of type facial placode , abnormal
head lacks all parts of type facial ganglion , abnormal
head lacks all parts of type vagal ganglion 4 , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium increased length , abnormal
posterior lateral line primordium absent , abnormal
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 ZFA:0001197 pars intermedia pars intermedia physical object quality , abnormal
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 ZFA:0001271 neurohypophysis neurohypophysis innervation decreased occurrence , abnormal
neurohypophysis vasculogenesis decreased occurrence , abnormal
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 ZFA:0001282 adenohypophysis adenohypophysis decreased object quality , abnormal
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 ZFA:0001295 facial placode facial placode neurogenesis decreased occurrence , abnormal
facial placode poorly differentiated , abnormal
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 ZFA:0001296 glossopharyngeal placode glossopharyngeal placode neurogenesis decreased occurrence , abnormal
glossopharyngeal placode poorly differentiated , abnormal
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 ZFA:0001297 vagal placode 1 vagal placode 1 neurogenesis decreased occurrence , abnormal
vagal placode 1 poorly differentiated , abnormal
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 ZFA:0001298 vagal placode 2 vagal placode 2 neurogenesis decreased occurrence , abnormal
vagal placode 2 poorly differentiated , abnormal
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 ZFA:0001299 vagal placode 3 vagal placode 3 neurogenesis decreased occurrence , abnormal
vagal placode 3 poorly differentiated , abnormal
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 ZFA:0001300 vagal placode 4 vagal placode 4 neurogenesis decreased occurrence , abnormal
vagal placode 4 neuroblast (sensu Vertebrata) mislocalised ventrally , abnormal
vagal placode 4 poorly differentiated , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage aplastic , abnormal
ceratohyal cartilage malformed , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage hypoplastic , abnormal
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 ZFA:0001470 anterior lateral line anterior lateral line decreased object quality , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
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 ZFA:0001607 pharyngeal arch 4 pharyngeal arch 4 has fewer parts of type cranial neural crest , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000032617 fgfrl1a / fibroblast growth factor receptor like 1a / Q91V87* / FGFRL1* / Q8N441* / fibroblast growth factor receptor like 1*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / complex
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000105230 fgf4 / fibroblast growth factor 4 / P08620* / P11403*  / complex / reaction
 ENSDARG00000076895 flrt3 / fibronectin leucine rich transmembrane 3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3* / Leucine-rich repeat transmembrane protein FLRT3 *  / complex / reaction
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000075597 flrt1b / fibronectin leucine rich transmembrane protein 1b / FLRT1* / Q6RKD8* / Q9NZU1* / fibronectin leucine rich transmembrane protein 1* / Leucine-rich repeat transmembrane protein FLRT1 *  / reaction / complex
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / reaction / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000079355 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000097299 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction






 

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