ENSDARG00000076510


Danio rerio

Features
Gene ID: ENSDARG00000076510
  
Biological name :fgf22
  
Synonyms : fgf22 / fibroblast growth factor 22
  
Possible biological names infered from orthology : Q9ESS2 / Q9HCT0
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 19111444
Gene end: 19156332
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000103162
NCBI entrez gene - 100005852     See in Manteia.
RefSeq - NM_001040095
RefSeq Peptide - NP_001035184
swissprot - Q1XG76
ZFIN ID - ZDB-GENE-050208-380
Ensembl - ENSDARG00000076510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF22ENSGALG00000041822Gallus gallus
 FGF22ENSG00000070388Homo sapiens
 Fgf22ENSMUSG00000020327Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*ENSDARG0000010047544
fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*ENSDARG0000003093243
fgf3 / P48802 / fibroblast growth factor 3 / P11487*ENSDARG0000010154037
fgf7 / fibroblast growth factor 7 / P21781*ENSDARG0000005938735
fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000008607033
fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000000735632
fgf16 / Q2HXK8 / fibroblast growth factor 16 / O43320* / Q9ESL8*ENSDARG0000004223330
fgf6a / fibroblast growth factor 6a / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000000935129
fgf6b / fibroblast growth factor 6b / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000004585629
fgf5 / fibroblast growth factor 5 / P12034* / P15656*ENSDARG0000003537729
fgf4 / fibroblast growth factor 4 / P08620* / P11403*ENSDARG0000010523028
fgf14 / fibroblast growth factor 14 / Q92915*ENSDARG0000004098226
fgf13a / fibroblast growth factor 13a / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000003505626
fgf11b / fibroblast growth factor 11b / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000004390725
fgf13b / fibroblast growth factor 13b / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000005663325
fgf11a / fibroblast growth factor 11a / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000006966225
fgf12b / fibroblast growth factor 12b / FGF12* / P61328* / fibroblast growth factor 12*ENSDARG0000011352524
fgf12a / fibroblast growth factor 12a / FGF12* / P61329* / P61328* / fibroblast growth factor 12*ENSDARG0000002795724
fgf9 / fibroblast growth factor 9ENSDARG0000007862523


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028296  Fibroblast growth factor 22


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021509 roof plate formation IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0033278 cell proliferation in midbrain IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000109 forebrain forebrain morphology , abnormal
Show

 ZFA:0000128 midbrain midbrain morphology , abnormal
Show

 ZFA:0000355 roof plate midbrain region roof plate midbrain region increased width , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000032617 fgfrl1a / fibroblast growth factor receptor like 1a / Q91V87* / FGFRL1* / Q8N441* / fibroblast growth factor receptor like 1*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000039963 fgfbp1b / fibroblast growth factor binding protein 1b / Q14512* / FGFBP1* / O70514* / fibroblast growth factor binding protein 1*  / reaction / complex
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000091660 fgfbp1b / fibroblast growth factor binding protein 1b / FGFBP1* / Q14512* / fibroblast growth factor binding protein 1*  / reaction / complex
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction / complex
 ENSDARG00000079355 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / reaction / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000075597 flrt1b / fibronectin leucine rich transmembrane protein 1b / FLRT1* / Q6RKD8* / Q9NZU1* / fibronectin leucine rich transmembrane protein 1* / Leucine-rich repeat transmembrane protein FLRT1 *  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / complex / reaction
 ENSDARG00000076895 flrt3 / fibronectin leucine rich transmembrane 3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3* / Leucine-rich repeat transmembrane protein FLRT3 *  / complex / reaction
 ENSDARG00000097299 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / complex
 ENSDARG00000105230 fgf4 / fibroblast growth factor 4 / P08620* / P11403*  / reaction / complex
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr