ENSG00000070388


Homo sapiens

Features
Gene ID: ENSG00000070388
  
Biological name :FGF22
  
Synonyms : FGF22 / fibroblast growth factor 22 / Q9HCT0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 639879
Gene end: 644371
  
Corresponding Affymetrix probe sets: 1566814_at (Human Genome U133 Plus 2.0 Array)   1566816_at (Human Genome U133 Plus 2.0 Array)   221315_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000215530
Ensembl peptide - ENSP00000466004
NCBI entrez gene - 27006     See in Manteia.
OMIM - 605831
RefSeq - NM_001300812
RefSeq - NM_020637
RefSeq Peptide - NP_001287741
RefSeq Peptide - NP_065688
swissprot - Q9HCT0
swissprot - K7ELB9
Ensembl - ENSG00000070388
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf22ENSDARG00000076510Danio rerio
 FGF22ENSGALG00000041822Gallus gallus
 Fgf22ENSMUSG00000020327Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF10 / O15520 / fibroblast growth factor 10ENSG0000007019349
FGF7 / P21781 / fibroblast growth factor 7ENSG0000014028541
FGF20 / Q9NP95 / fibroblast growth factor 20ENSG0000007857940
FGF3 / P11487 / fibroblast growth factor 3ENSG0000018689539
FGF9 / P31371 / fibroblast growth factor 9ENSG0000010267837
FGF16 / O43320 / fibroblast growth factor 16ENSG0000019646836
FGF4 / P08620 / fibroblast growth factor 4ENSG0000007538833
FGF6 / P10767 / fibroblast growth factor 6ENSG0000011124132
FGF5 / P12034 / fibroblast growth factor 5ENSG0000013867532
FGF11 / Q92914 / fibroblast growth factor 11ENSG0000016195830
FGF12 / P61328 / fibroblast growth factor 12ENSG0000011427929
FGF14 / Q92915 / fibroblast growth factor 14ENSG0000010246628
FGF13 / Q92913 / fibroblast growth factor 13ENSG0000012968225


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028296  Fibroblast growth factor 22


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space NAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Signaling by FGFR2 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137440 FGFBP1 / Q14512 / fibroblast growth factor binding protein 1  / complex / reaction






 

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