ENSG00000075388


Homo sapiens

Features
Gene ID: ENSG00000075388
  
Biological name :FGF4
  
Synonyms : FGF4 / fibroblast growth factor 4 / P08620
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.3
Gene start: 69771016
Gene end: 69775403
  
Corresponding Affymetrix probe sets: 1552982_a_at (Human Genome U133 Plus 2.0 Array)   206783_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000168712
NCBI entrez gene - 2249     See in Manteia.
OMIM - 164980
RefSeq - NM_002007
RefSeq Peptide - NP_001998
swissprot - P08620
Ensembl - ENSG00000075388
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf4ENSDARG00000105230Danio rerio
 FGF4ENSGALG00000007562Gallus gallus
 Fgf4ENSMUSG00000050917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF6 / P10767 / fibroblast growth factor 6ENSG0000011124153
FGF5 / P12034 / fibroblast growth factor 5ENSG0000013867537
FGF20 / Q9NP95 / fibroblast growth factor 20ENSG0000007857934
FGF9 / P31371 / fibroblast growth factor 9ENSG0000010267831
FGF16 / O43320 / fibroblast growth factor 16ENSG0000019646829
FGF11 / Q92914 / fibroblast growth factor 11ENSG0000016195829
FGF22 / Q9HCT0 / fibroblast growth factor 22ENSG0000007038827
FGF14 / Q92915 / fibroblast growth factor 14ENSG0000010246627
FGF7 / P21781 / fibroblast growth factor 7ENSG0000014028526
FGF10 / O15520 / fibroblast growth factor 10ENSG0000007019326
FGF13 / Q92913 / fibroblast growth factor 13ENSG0000012968226
FGF3 / P11487 / fibroblast growth factor 3ENSG0000018689526
FGF12 / P61328 / fibroblast growth factor 12ENSG0000011427926


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028239  Fibroblast growth factor 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0010463 mesenchymal cell proliferation IDA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060363 cranial suture morphogenesis IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IEA
 biological_processGO:0060591 chondroblast differentiation IDA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR3 point mutants in cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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