ENSMUSG00000050917


Mus musculus

Features
Gene ID: ENSMUSG00000050917
  
Biological name :Fgf4
  
Synonyms : Fgf4 / Fibroblast growth factor 4 / P11403
  
Possible biological names infered from orthology : P08620
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F5
Gene start: 144847367
Gene end: 144865243
  
Corresponding Affymetrix probe sets: 10559367 (MoGene1.0st)   1420085_at (Mouse Genome 430 2.0 Array)   1420086_x_at (Mouse Genome 430 2.0 Array)   1449729_at (Mouse Genome 430 2.0 Array)   1450282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146975
Ensembl peptide - ENSMUSP00000056752
NCBI entrez gene - 14175     See in Manteia.
MGI - MGI:95518
RefSeq - NM_010202
RefSeq Peptide - NP_034332
swissprot - A0A140LIV6
swissprot - P11403
Ensembl - ENSMUSG00000050917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf4ENSDARG00000105230Danio rerio
 FGF4ENSGALG00000007562Gallus gallus
 FGF4ENSG00000075388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*ENSMUSG0000000018352
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*ENSMUSG0000002933736
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*ENSMUSG0000003160332
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197428
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282627
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123027
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*ENSMUSG0000002252327
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555127
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*ENSMUSG0000003113726
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107426
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*ENSMUSG0000002032725
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*ENSMUSG0000002720825
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173225


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028239  Fibroblast growth factor 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISO
 biological_processGO:0010463 mesenchymal cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0019827 stem cell population maintenance IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0035116 embryonic hindlimb morphogenesis IGI
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IDA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060363 cranial suture morphogenesis IDA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IGI
 biological_processGO:0060591 chondroblast differentiation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Casc3Gt(RRU345)Byg/Casc3tm1(KOMP)Vlcg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Casc3Gt(RRU345)Byg/Casc3tm1(KOMP)Vlcg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Fgf3tm1Lwd/Fgf3tm1Lwd,Fgf4tm1.1Lwd/Fgf4tm1.1Lwd
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgf3tm1Lwd/Fgf3tm1Lwd,Fgf4tm1.1Lwd/Fgf4tm1.2Lwd
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcdh15tm2.1Mll/Pcdh15tm2.1Mll
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: Pcdh15tm2.1Mll/Pcdh15tm2.1Mll
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Pcdh15tm2.1Mll/Pcdh15tm2.1Mll
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fgf4tm1Bas/Fgf4tm1Bas
Genetic Background: involves: 129S6/SvEvTac

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pcdh15tm2.1Mll/Pcdh15tm2.1Mll
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf3tm1Lwd/Fgf3tm1Lwd,Fgf4tm1.1Lwd/Fgf4tm1.1Lwd
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcdh15tm2.1Mll/Pcdh15tm2.1Mll
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0012113 decreased inner cell mass proliferation 
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Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Fgf3tm1Lwd/Fgf3tm1Lwd,Fgf4tm1.1Lwd/Fgf4tm1.2Lwd
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
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Allelic Composition: Fgf3tm1Lwd/Fgf3tm1Lwd,Fgf4tm1.1Lwd/Fgf4tm1.1Lwd
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

Allelic Composition: Fgf3tm1Lwd/Fgf3tm1Lwd,Fgf4tm1.1Lwd/Fgf4tm1.2Lwd
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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