ENSMUSG00000027208


Mus musculus

Features
Gene ID: ENSMUSG00000027208
  
Biological name :Fgf7
  
Synonyms : Fgf7 / Fibroblast growth factor 7 / P36363
  
Possible biological names infered from orthology : P21781
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 126034658
Gene end: 126091185
  
Corresponding Affymetrix probe sets: 10475643 (MoGene1.0st)   1422243_at (Mouse Genome 430 2.0 Array)   1438405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069681
Ensembl peptide - ENSMUSP00000106072
NCBI entrez gene - 14178     See in Manteia.
MGI - MGI:95521
RefSeq - NM_008008
RefSeq Peptide - NP_032034
swissprot - P36363
swissprot - Q544I6
Ensembl - ENSMUSG00000027208
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf7ENSDARG00000059387Danio rerio
 FGF7ENSGALG00000028158Gallus gallus
 FGF7ENSG00000140285Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173249
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*ENSMUSG0000002032736
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107435
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*ENSMUSG0000003160335
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123034
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*ENSMUSG0000002933732
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197432
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*ENSMUSG0000000018328
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*ENSMUSG0000003113727
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282626
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555126
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*ENSMUSG0000005091726
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*ENSMUSG0000002252325


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028247  Fibroblast growth factor 7


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISO
 biological_processGO:0010463 mesenchymal cell proliferation ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010838 positive regulation of keratinocyte proliferation ISO
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0034394 protein localization to cell surface ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050918 positive chemotaxis ISO
 biological_processGO:0051549 positive regulation of keratinocyte migration ISO
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IDA
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
 biological_processGO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
 biological_processGO:0061033 secretion by lung epithelial cell involved in lung growth ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042056 chemoattractant activity ISO


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade; FGFR2
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR2 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0002881 long hair "increased average length of the coat hairs" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0003795 abnormal bone structure 
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Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0003846 matted coat "coat hairs sticks together to form clumps and does not lie flat" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004793 abnormal synaptic vesicle clustering "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
Show

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0011331 abnormal papillary duct morphology "any structural anomaly of the largest straight excretory ducts in the kidney medulla and papillae that are a continuation of the collecting tubules, and that open into the area cribosa" [ISBN:0-683-40008-8]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0011333 abnormal kidney inner medulla morphology "any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle" [MGI:csmith, PMID:20614633]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0011360 kidney cortex hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the outer portion of the kidney, which contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts" [MGI:anna]
Show

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0011565 kidney papillary hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the apex of the renal pyramid that normally projects into a calyx" [MGI:anna]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048373 Fgfbp1 / O70514 / Fibroblast growth factor-binding protein 1 / Q14512*  / complex / reaction






 

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