ENSMUSG00000000183


Mus musculus

Features
Gene ID: ENSMUSG00000000183
  
Biological name :Fgf6
  
Synonyms : Fgf6 / Fibroblast growth factor 6 / P21658
  
Possible biological names infered from orthology : P10767
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F3
Gene start: 127015586
Gene end: 127028187
  
Corresponding Affymetrix probe sets: 10542023 (MoGene1.0st)   1427582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000187
NCBI entrez gene - 14177     See in Manteia.
MGI - MGI:95520
RefSeq - NM_010204
RefSeq Peptide - NP_034334
swissprot - P21658
Ensembl - ENSMUSG00000000183
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf6aENSDARG00000009351Danio rerio
 fgf6bENSDARG00000045856Danio rerio
 FGF6ENSGALG00000017287Gallus gallus
 FGF6ENSG00000111241Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*ENSMUSG0000005091751
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*ENSMUSG0000002933736
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*ENSMUSG0000003160331
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107431
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197431
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173230
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123029
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282627
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*ENSMUSG0000003113727
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*ENSMUSG0000002252327
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555127
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*ENSMUSG0000002720826
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*ENSMUSG0000002032724


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028242  Fibroblast growth factor 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IGI
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045445 myoblast differentiation IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0000730 increased number of satellite cells "greater number of unfused cells in muscle that play a role in muscle regeneration" [J:42574]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Dmdmdx/?,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S4/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

Allelic Composition: Dmdmdx/?,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S4/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB * ICR

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd79atm3Cgn/Cd79atm3Cgn,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/?
Genetic Background: B6.B10ScSn-Dmdmdx

 MP:0002881 long hair "increased average length of the coat hairs" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003358 abnormal hypaxial muscle morphology "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/?,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S4/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

Allelic Composition: Dmdmdx/?,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S4/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0004248 abnormal epaxial muscle morphology "any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996]
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Allelic Composition: Dmdmdx/?,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S4/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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