ENSMUSG00000020327


Mus musculus

Features
Gene ID: ENSMUSG00000020327
  
Biological name :Fgf22
  
Synonyms : Fgf22 / Fibroblast growth factor 22 / Q9ESS2
  
Possible biological names infered from orthology : Q9HCT0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79755076
Gene end: 79758596
  
Corresponding Affymetrix probe sets: 10364489 (MoGene1.0st)   1450205_at (Mouse Genome 430 2.0 Array)   1460296_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151917
Ensembl peptide - ENSMUSP00000020577
Ensembl peptide - ENSMUSP00000151743
NCBI entrez gene - 67112     See in Manteia.
MGI - MGI:1914362
RefSeq - NM_023304
RefSeq - XM_006513973
RefSeq Peptide - NP_075793
swissprot - A0A1X7SB63
swissprot - Q0VER9
swissprot - Q9ESS2
Ensembl - ENSMUSG00000020327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf22ENSDARG00000076510Danio rerio
 FGF22ENSGALG00000041822Gallus gallus
 FGF22ENSG00000070388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173248
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*ENSMUSG0000003160343
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*ENSMUSG0000002720843
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107442
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197441
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123041
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*ENSMUSG0000005091731
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*ENSMUSG0000000018331
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*ENSMUSG0000002933731
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282629
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*ENSMUSG0000002252329
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555127
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*ENSMUSG0000003113725


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028296  Fibroblast growth factor 22


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf10tm1.1(cre/ERT2)Sbel/Fgf10tm1Sms,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004793 abnormal synaptic vesicle clustering "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048373 Fgfbp1 / O70514 / Fibroblast growth factor-binding protein 1 / Q14512*  / reaction / complex






 

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