ENSMUSG00000029337


Mus musculus

Features
Gene ID: ENSMUSG00000029337
  
Biological name :Fgf5
  
Synonyms : Fgf5 / Fibroblast growth factor 5 / P15656
  
Possible biological names infered from orthology : P12034
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E3
Gene start: 98254184
Gene end: 98277030
  
Corresponding Affymetrix probe sets: 10523490 (MoGene1.0st)   1426186_a_at (Mouse Genome 430 2.0 Array)   1438883_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031280
Ensembl peptide - ENSMUSP00000142420
NCBI entrez gene - 14176     See in Manteia.
MGI - MGI:95519
RefSeq - NM_001277268
RefSeq - NM_010203
RefSeq Peptide - NP_001264197
RefSeq Peptide - NP_034333
swissprot - P15656
Ensembl - ENSMUSG00000029337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf5ENSDARG00000035377Danio rerio
 FGF5ENSGALG00000045521Gallus gallus
 FGF5ENSG00000138675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*ENSMUSG0000005091728
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*ENSMUSG0000000018328
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*ENSMUSG0000003160327
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107427
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123026
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197424
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173223
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*ENSMUSG0000002720823
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555121
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*ENSMUSG0000003113721
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282620
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*ENSMUSG0000002252320
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*ENSMUSG0000002032719


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028240  Fibroblast growth factor 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISO
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding ISO
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0000397 abnormal guard hair "anomalies of truncal hairs that contain two air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001281 increased vibrissae length "longer average length of the whiskers" [J:65037]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

Allelic Composition: Fgf5tm1Mrt/Fgf5tm1Mrt
Genetic Background: involves: 129 * C57BL/6

 MP:0002881 long hair "increased average length of the coat hairs" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

Allelic Composition: Fgf5tm1Mrt/Fgf5tm1Mrt
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Fgf5m1Btlr/Fgf5m1Btlr
Genetic Background: C57BL/6J-Fgf5m1Btlr

Allelic Composition: Fgf5m2Btlr/Fgf5m2Btlr
Genetic Background: C57BL/6J-Fgf5m2Btlr

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0009271 increased guard hair length "increase in the length of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities"]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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