Manteia - Molecule gene

ENSMUSG00000021974

Mus musculus

Features

Gene ID:	ENSMUSG00000021974

Biological name :	Fgf9

Synonyms :	Fgf9 / Fibroblast growth factor 9 / P54130

Possible biological names infered from orthology :	P31371

Species:	Mus musculus

Chr. number:	14
Strand:	1
Band:	C3
Gene start:	58070547
Gene end:	58112720

Corresponding Affymetrix probe sets:	10415651 (MoGene1.0st) 1420795_at (Mouse Genome 430 2.0 Array) 1438718_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000088143 Ensembl peptide - ENSMUSP00000131358 Ensembl peptide - ENSMUSP00000130066 Ensembl peptide - ENSMUSP00000022545 NCBI entrez gene - 14180 See in Manteia. MGI - MGI:104723 RefSeq - NM_013518 RefSeq Peptide - NP_038546 swissprot - E9Q864 swissprot - E9Q2N2 swissprot - P54130 Ensembl - ENSMUSG00000021974

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
FGF9	ENSGALG00000025748	Gallus gallus
FGF9	ENSG00000102678	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*	ENSMUSG00000031603	72
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*	ENSMUSG00000031230	70
Fgf3 / fibroblast growth factor 3 / P11487*	ENSMUSG00000031074	33
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*	ENSMUSG00000031137	32
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*	ENSMUSG00000020327	32
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*	ENSMUSG00000029337	31
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*	ENSMUSG00000000183	31
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*	ENSMUSG00000022523	30
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*	ENSMUSG00000027208	30
Fgf14 / fibroblast growth factor 14 / Q92915*	ENSMUSG00000025551	30
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*	ENSMUSG00000042826	29
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*	ENSMUSG00000021732	29
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*	ENSMUSG00000050917	27

Protein motifs (from Interpro)

Interpro ID	Name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF
IPR028251	Fibroblast growth factor 9

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0001525	angiogenesis	IMP
biological_process	GO:0001649	osteoblast differentiation	IMP
biological_process	GO:0001654	eye development	IMP
biological_process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP
biological_process	GO:0002062	chondrocyte differentiation	IMP
biological_process	GO:0003214	cardiac left ventricle morphogenesis	TAS
biological_process	GO:0003231	cardiac ventricle development	TAS
biological_process	GO:0006606	protein import into nucleus	IMP
biological_process	GO:0007267	cell-cell signaling	IMP
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	IEA
biological_process	GO:0008584	male gonad development	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010628	positive regulation of gene expression	IDA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030178	negative regulation of Wnt signaling pathway	IGI
biological_process	GO:0030238	male sex determination	IMP
biological_process	GO:0030324	lung development	IMP
biological_process	GO:0030326	embryonic limb morphogenesis	IMP
biological_process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP
biological_process	GO:0032927	positive regulation of activin receptor signaling pathway	IDA
biological_process	GO:0042472	inner ear morphogenesis	IMP
biological_process	GO:0043410	positive regulation of MAPK cascade	IEA
biological_process	GO:0045880	positive regulation of smoothened signaling pathway	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	TAS
biological_process	GO:0048505	regulation of timing of cell differentiation	IMP
biological_process	GO:0048566	embryonic digestive tract development	IMP
biological_process	GO:0048706	embryonic skeletal system development	IMP
biological_process	GO:0050679	positive regulation of epithelial cell proliferation	IMP
biological_process	GO:0051781	positive regulation of cell division	IEA
biological_process	GO:0060045	positive regulation of cardiac muscle cell proliferation	TAS
biological_process	GO:0060484	lung-associated mesenchyme development	IMP
biological_process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	TAS
biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP
biological_process	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005604	basement membrane	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0005104	fibroblast growth factor receptor binding	IEA
molecular_function	GO:0008083	growth factor activity	IEA
molecular_function	GO:0008201	heparin binding	IEA

Pathways (from Reactome)

Pathway description

PIP3 activates AKT signaling

FGFR4 ligand binding and activation

FGFR3b ligand binding and activation

FGFR3c ligand binding and activation

FGFR1c ligand binding and activation

FGFR2c ligand binding and activation

Phospholipase C-mediated cascade: FGFR1

Phospholipase C-mediated cascade; FGFR2

Phospholipase C-mediated cascade; FGFR3

Phospholipase C-mediated cascade; FGFR4

Downstream signaling of activated FGFR1

SHC-mediated cascade:FGFR1

PI-3K cascade:FGFR1

FRS-mediated FGFR1 signaling

PI-3K cascade:FGFR2

SHC-mediated cascade:FGFR2

FRS-mediated FGFR2 signaling

SHC-mediated cascade:FGFR3

FRS-mediated FGFR3 signaling

PI-3K cascade:FGFR3

FRS-mediated FGFR4 signaling

SHC-mediated cascade:FGFR4

PI-3K cascade:FGFR4

Negative regulation of FGFR1 signaling

Negative regulation of FGFR2 signaling

Negative regulation of FGFR3 signaling

Negative regulation of FGFR4 signaling

RAF/MAP kinase cascade

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000030	abnormal tympanic ring morphology	"malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000091	short premaxilla	"reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/J
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Kmt2a^tm2Sjk/Kmt2a⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9⁺ Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0000494	abnormal cecum morphology	"malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0000496	abnormal small intestine morphology	"structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000552	abnormal radius morphology	"malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000566	synostosis	"osseous union of two bones that are not normally connected" [J:13049]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf9^Eks/Fgf9⁺ Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Fgf9^Eks/Fgf9^tm1Dor Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J Allelic Composition: Fgf9^tm1Dor/Fgf9⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Fgf9^Eks/Fgf9⁺ Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Fgf9^tm1.2Fwan/Fgf9^tm1.2Fwan Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0001300	ocular hypertelorism	"increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9⁺ Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf9^Aca12/Fgf9⁺ Genetic Background: involves: C57BL/6J
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9⁺ Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf9^Eks/Fgf9⁺ Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001940	testicular hypoplasia	"decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Fgf9^tm1.2Fwan/Fgf9^tm1.2Fwan Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0001956	hypopnea	"breathing that is shallower and/or slower than normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64289]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002090	abnormal vision	"inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf9^Aca12/Fgf9⁺ Genetic Background: involves: C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn Genetic Background: NOD.Cg-H2^b Il4^tm1Cgn
MP:0002211	abnormal primary sex determination	"aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0002740	heart hypoplasia	"decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]	Show Allelic Composition: Kmt2a^tm2Sjk/Kmt2a⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Fgf2^tm1Doe/Fgf2^tm1Doe,Fgf9^tm1Dor/Fgf9^tm1Dor Genetic Background: involves: C57BL/6J
MP:0002750	exophthalmos	"protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2a^tm2Sjk/Kmt2a⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002754	dilated right ventricle	"an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2a^tm2Sjk/Kmt2a⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002765	short fibula	"reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9⁺ Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0002804	abnormal motor learning	"defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9⁺ Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0002932	abnormal joint	"defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002995	primary sex reversal	"gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0002996	ovotestis	"gonad with both ovarian and testicular tissue" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003140	dilated atria	"an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0003189	fused joints		Show Allelic Composition: Fgf9^Eks/Fgf9⁺ Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003385	abnormal body wall	"malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/J
MP:0003491	abnormal voluntary movement	"anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003567	abnormal cardiomyocyte proliferation	"anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2a^tm2Sjk/Kmt2a⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Fgf9^tm1.2Fwan/Fgf9^tm1.2Fwan Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf9^tm1.2Fwan/Fgf9^tm1.2Fwan Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004109	abnormal Sertoli cell development	"anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0004321	short sternum	"reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004351	short humerus	"reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004355	short radius	"reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004359	short ulna	"reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004471	short nasal bone	"reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004613	fusion of vertebral arches	"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004676	wide ribs	"an increase in the width of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004841	abnormal small intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0004932	epididymis hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0005039	hypoxia	"reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0005272	abnormal temporal bone morphology	"anomalous structure of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005296	abnormal humerus morphology	"malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005387	immune system phenotype		Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9⁺ Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0005545	abnormal lens development	"aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005631	decreased lung weight	"less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8⁺,Fgf9^tm1Dor/Fgf9⁺,Fgfr3^tm1.1Aomw/Fgfr3⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Fgf9^tm1Dor/Fgf9⁺,Fgfr3^tm1.1Aomw/Fgfr3⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0006418	abnormal testis cord formation	"any structural anomaly in the formation of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence; defective testis cord formation is most likely to reflect abnormal function of either Sertoli cells or peritubular myoid (PTM) cells which normally cooperate to deposit a layer of basal lamina that defines the edges of individual testis cords" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0006419	disorganized testis cords	"derangement of the pattern of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0006421	decreased number of peritubular myoid cells	"reduced number of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0008022	dilated heart ventricles	"the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0008158	increased diameter of femur	"increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008159	increased diameter of fibula	"increased width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008160	increased diameter of humerus	"increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008161	increased diameter of radius	"increased width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008162	increased diameter of tibia	"increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008163	increased diameter of ulna	"increased width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008725	enlarged heart atrium	"increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]	Show Allelic Composition: Kmt2a^tm2Sjk/Kmt2a⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Fgf2^tm1Doe/Fgf2^tm1Doe,Fgf9^tm1Dor/Fgf9^tm1Dor Genetic Background: involves: C57BL/6J
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0009829	enlarged eye anterior chamber	"increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067, MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf9^Aca12/Fgf9⁺ Genetic Background: involves: C57BL/6J
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0011024	abnormal branching involved in lung morphogenesis	"anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0011084	partial lethality at weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]	Show Allelic Composition: Fgf9^Eks/Fgf9⁺ Genetic Background: involves: C57BL/6J * DBA/2J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn Genetic Background: NOD.Cg-H2^b Il4^tm1Cgn
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Fgf9^tm1.2Fwan/Fgf9^tm1.2Fwan Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/J Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0011142	abnormal lung-associated mesenchyme development	"abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]	Show Allelic Composition: Jak2^tm2.2Jlvl/Jak2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL
MP:0011146	abnormal mesenchymal cell proliferation involved in lung development	"anomaly in the ability of the differentiating lung mesenchymal cell population to undergo expansion by cell division in the developing lung" [MGI:anna]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8⁺,Fgf9^tm1Dor/Fgf9⁺,Fgfr3^tm1.1Aomw/Fgfr3⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Fgf9^tm1Dor/Fgf9⁺,Fgfr3^tm1.1Aomw/Fgfr3⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0012085	midface hypoplasia	"underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face" [MGI:anna]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/J
MP:0013602	abnormal Leydig cell differentiation	"atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development comprises two sequential but overlapping cell lineages known as the fetal and adult type LC populations, which display distinct functional characteristics reflected by different morphology, hormonal regulation, and steroidogenic output" [http://press.endocrine.org/doi/full/10.1210/en.2012-2273, MGI:Anna]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0030032	high forehead	"an abnormally increased height of the forehead" [HP:0000348]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0030350	premature coronal suture closure	"early closure of the coronal suture of the skull" [MGI:anna]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0030354	premature sagittal suture closure	"early closure of the sagittal suture of the skull; premature closure of this suture results in a long, narrow, and boat-shaped skull (scaphocephaly)" [https://radiopaedia.org/articles/craniosynostosis]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J
MP:0030372	enlarged Meckel s cartilage	"increased size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]	Show Allelic Composition: Fgf9^Eks/Fgf9^Eks Genetic Background: involves: C57BL/6J * DBA/2J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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