Manteia

ENSMUSG00000021732

Mus musculus

Features

Gene ID:	ENSMUSG00000021732

Biological name :	Fgf10

Synonyms :	Fgf10 / Fibroblast growth factor 10 / O35565

Possible biological names infered from orthology :	O15520

Species:	Mus musculus

Chr. number:	13
Strand:	1
Band:	D2.3
Gene start:	118669791
Gene end:	118792115

Corresponding Affymetrix probe sets:	10407350 (MoGene1.0st) 1420690_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000022246 NCBI entrez gene - 14165 See in Manteia. MGI - MGI:1099809 RefSeq - NM_008002 RefSeq Peptide - NP_032028 swissprot - O35565 Ensembl - ENSMUSG00000021732

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fgf10a	ENSDARG00000030932	Danio rerio
fgf10b	ENSDARG00000100475	Danio rerio
FGF10	ENSGALG00000014872	Gallus gallus
FGF10	ENSG00000070193	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*	ENSMUSG00000027208	45
Fgf3 / fibroblast growth factor 3 / P11487*	ENSMUSG00000031074	38
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*	ENSMUSG00000020327	37
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*	ENSMUSG00000029337	30
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*	ENSMUSG00000000183	30
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*	ENSMUSG00000031603	30
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*	ENSMUSG00000031230	29
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*	ENSMUSG00000021974	29
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*	ENSMUSG00000031137	26
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*	ENSMUSG00000022523	25
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*	ENSMUSG00000050917	24
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*	ENSMUSG00000042826	22
Fgf14 / fibroblast growth factor 14 / Q92915*	ENSMUSG00000025551	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF
IPR028252	Fibroblast growth factor 10

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000132	establishment of mitotic spindle orientation	IGI
biological_process	GO:0000187	activation of MAPK activity	IEA
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0001656	metanephros development	IEA
biological_process	GO:0001759	organ induction	IEA
biological_process	GO:0001823	mesonephros development	IEA
biological_process	GO:0001974	blood vessel remodeling	IGI
biological_process	GO:0003338	metanephros morphogenesis	IMP
biological_process	GO:0006935	chemotaxis	IDA
biological_process	GO:0007267	cell-cell signaling	IMP
biological_process	GO:0007368	determination of left/right symmetry	IMP
biological_process	GO:0007431	salivary gland development	IEA
biological_process	GO:0007435	salivary gland morphogenesis	IMP
biological_process	GO:0008284	positive regulation of cell proliferation	IDA
biological_process	GO:0008285	negative regulation of cell proliferation	IDA
biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	IEA
biological_process	GO:0008544	epidermis development	IMP
biological_process	GO:0008589	regulation of smoothened signaling pathway	IMP
biological_process	GO:0009880	embryonic pattern specification	IMP
biological_process	GO:0009887	animal organ morphogenesis	IMP
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010631	epithelial cell migration	IMP
biological_process	GO:0010634	positive regulation of epithelial cell migration	IEA
biological_process	GO:0010838	positive regulation of keratinocyte proliferation	IEA
biological_process	GO:0014070	response to organic cyclic compound	IEA
biological_process	GO:0021983	pituitary gland development	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030177	positive regulation of Wnt signaling pathway	IMP
biological_process	GO:0030324	lung development	IMP
biological_process	GO:0030538	embryonic genitalia morphogenesis	IMP
biological_process	GO:0030855	epithelial cell differentiation	IMP
biological_process	GO:0030878	thyroid gland development	IMP
biological_process	GO:0030916	otic vesicle formation	TAS
biological_process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP
biological_process	GO:0031016	pancreas development	IMP
biological_process	GO:0031069	hair follicle morphogenesis	IMP
biological_process	GO:0031076	embryonic camera-type eye development	IMP
biological_process	GO:0031532	actin cytoskeleton reorganization	IEA
biological_process	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle	IEA
biological_process	GO:0032355	response to estradiol	IEA
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0032781	positive regulation of ATPase activity	IEA
biological_process	GO:0032808	lacrimal gland development	IEA
biological_process	GO:0032925	regulation of activin receptor signaling pathway	IMP
biological_process	GO:0034394	protein localization to cell surface	IEA
biological_process	GO:0035019	somatic stem cell population maintenance	IMP
biological_process	GO:0035108	limb morphogenesis	IMP
biological_process	GO:0035265	organ growth	IMP
biological_process	GO:0042060	wound healing	IEA
biological_process	GO:0042246	tissue regeneration	IEA
biological_process	GO:0042472	inner ear morphogenesis	IMP
biological_process	GO:0042475	odontogenesis of dentin-containing tooth	IMP
biological_process	GO:0042693	muscle cell fate commitment	IMP
biological_process	GO:0043410	positive regulation of MAPK cascade	IEA
biological_process	GO:0043616	keratinocyte proliferation	IMP
biological_process	GO:0045596	negative regulation of cell differentiation	IDA
biological_process	GO:0045739	positive regulation of DNA repair	IEA
biological_process	GO:0045740	positive regulation of DNA replication	IEA
biological_process	GO:0045747	positive regulation of Notch signaling pathway	IGI
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045931	positive regulation of mitotic cell cycle	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0046579	positive regulation of Ras protein signal transduction	IEA
biological_process	GO:0046877	regulation of saliva secretion	IEA
biological_process	GO:0048146	positive regulation of fibroblast proliferation	IMP
biological_process	GO:0048286	lung alveolus development	IMP
biological_process	GO:0048514	blood vessel morphogenesis	IMP
biological_process	GO:0048536	spleen development	IMP
biological_process	GO:0048538	thymus development	IEA
biological_process	GO:0048557	embryonic digestive tract morphogenesis	IMP
biological_process	GO:0048565	digestive tract development	IMP
biological_process	GO:0048566	embryonic digestive tract development	IMP
biological_process	GO:0048645	animal organ formation	IMP
biological_process	GO:0048730	epidermis morphogenesis	IMP
biological_process	GO:0048752	semicircular canal morphogenesis	IGI
biological_process	GO:0048754	branching morphogenesis of an epithelial tube	IEA
biological_process	GO:0048807	female genitalia morphogenesis	IMP
biological_process	GO:0048808	male genitalia morphogenesis	IMP
biological_process	GO:0050671	positive regulation of lymphocyte proliferation	IEA
biological_process	GO:0050673	epithelial cell proliferation	IEA
biological_process	GO:0050674	urothelial cell proliferation	IEA
biological_process	GO:0050677	positive regulation of urothelial cell proliferation	IEA
biological_process	GO:0050678	regulation of epithelial cell proliferation	IMP
biological_process	GO:0050679	positive regulation of epithelial cell proliferation	IEA
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0050872	white fat cell differentiation	IMP
biological_process	GO:0050918	positive chemotaxis	IEA
biological_process	GO:0050930	induction of positive chemotaxis	IDA
biological_process	GO:0051145	smooth muscle cell differentiation	IMP
biological_process	GO:0051549	positive regulation of keratinocyte migration	IEA
biological_process	GO:0060019	radial glial cell differentiation	IMP
biological_process	GO:0060173	limb development	IMP
biological_process	GO:0060174	limb bud formation	IMP
biological_process	GO:0060425	lung morphogenesis	IMP
biological_process	GO:0060428	lung epithelium development	IEA
biological_process	GO:0060430	lung saccule development	IEA
biological_process	GO:0060436	bronchiole morphogenesis	IMP
biological_process	GO:0060441	epithelial tube branching involved in lung morphogenesis	IMP
biological_process	GO:0060445	branching involved in salivary gland morphogenesis	IGI
biological_process	GO:0060447	bud outgrowth involved in lung branching	IEA
biological_process	GO:0060449	bud elongation involved in lung branching	IGI
biological_process	GO:0060496	mesenchymal-epithelial cell signaling involved in lung development	IDA
biological_process	GO:0060510	type II pneumocyte differentiation	IDA
biological_process	GO:0060513	prostatic bud formation	IGI
biological_process	GO:0060541	respiratory system development	IDA
biological_process	GO:0060594	mammary gland specification	IGI
biological_process	GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IEA
biological_process	GO:0060615	mammary gland bud formation	IMP
biological_process	GO:0060661	submandibular salivary gland formation	IMP
biological_process	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	IMP
biological_process	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA
biological_process	GO:0060667	branch elongation involved in salivary gland morphogenesis	IMP
biological_process	GO:0060879	semicircular canal fusion	IMP
biological_process	GO:0060915	mesenchymal cell differentiation involved in lung development	IGI
biological_process	GO:0061033	secretion by lung epithelial cell involved in lung growth	IEA
biological_process	GO:0061115	lung proximal/distal axis specification	IDA
biological_process	GO:0070075	tear secretion	IEA
biological_process	GO:0070352	positive regulation of white fat cell proliferation	IMP
biological_process	GO:0070371	ERK1 and ERK2 cascade	IEA
biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA
biological_process	GO:0070384	Harderian gland development	IMP
biological_process	GO:0071157	negative regulation of cell cycle arrest	IEA
biological_process	GO:0071338	positive regulation of hair follicle cell proliferation	IEA
biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP
biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0031012	extracellular matrix	IEA
molecular_function	GO:0005104	fibroblast growth factor receptor binding	ISO
molecular_function	GO:0005111	type 2 fibroblast growth factor receptor binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008083	growth factor activity	ISO
molecular_function	GO:0008201	heparin binding	IEA
molecular_function	GO:0042056	chemoattractant activity	IEA

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000003	abnormal adipose tissue morphology	"structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000034	abnormal vestibule morphology	"malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000149	abnormal scapula morphology	"malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000486	abnormal pulmonary trunk morphology	"structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000488	abnormal intestinal epithelium morphology	"anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA
MP:0000495	abnormal colon morphology	"malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^{tm1.1(cre/ERT2)Sbel} Genetic Background: involves: 129 * C57BL/6J
MP:0000537	abnormal urethra morphology	"anomalous structure of the canal leading from the bladder, discharging the urine externally" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000549	absent limbs	"missing extremities" [J:51966, J:50768]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf10^Mhdaaey17/Fgf10^Mhdaaey17 Genetic Background: C3HeB/FeJ-Fgf10^Mhdaaey17 Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ Allelic Composition: Fgf10^ptls/Fgf10^ptls Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^{tm1.1(cre/ERT2)Sbel} Genetic Background: involves: 129 * C57BL/6J
MP:0000551	absent forelimb	"missing the entire anterior extremities" [MGI:tc, J:54637]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000553	absent radius	"missing the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000557	absent hindlimb	"missing the entire posterior extremities" [MGI:tc, J:54637]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000571	interdigital webbing	"fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^{tm1.1(cre/ERT2)Sbel} Genetic Background: involves: 129 * C57BL/6J
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0000614	absent salivary gland	"missing any of the saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0000644	dextrocardia	"cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000662	abnormal branching of the mammary ductal tree	"anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000762	abnormal tongue morphology	"anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0001158	abnormal prostate morphology	"mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]	Show Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0001159	absent prostate gland	"missing gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66126]	Show Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0001181	absent lungs	"missing organs of respiration" [J:51966, J:50768]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Fgf10^ptls/Fgf10^ptls Genetic Background: involves: C57BL/6 * FVB/N
MP:0001182	lung hemorrhage	"bleeding in the respiratory organs" [J:66345]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0001199	thin skin	"reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0001201	translucent skin	"skin that is more transparent to light than normal " [J:15108]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0001218	thin epidermis	"reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Afg3l2^Emv66/Afg3l2^Emv66 Genetic Background: FVB.MEV2-Afg3l2^Emv66
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
MP:0001302	eyelids open at birth	"widely open eyes instead of closed at perinatal stage" [J:51966]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002102	abnormal ear morphology	"structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0002132	abnormal respiratory system morphology	"anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms,Fgf3^tm1.2Sms/Fgf3^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0002295	abnormal pulmonary circulation	"anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002297	abnormal forced expiratory flow rates	"anomaly in the rates of airflow during forced vital capacity determination" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Afg3l2^Emv66/Afg3l2^Emv66 Genetic Background: FVB.MEV2-Afg3l2^Emv66
MP:0002672	abnormal branchial arch artery morphology	"malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0002691	small stomach	"reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0002729	abnormal canal morphology	"any anomaly or malformation of the tubular ducts of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002770	absent bulbourethral gland	"missing gland in males that lie along the prostate gland that secrete a fluid component of the seminal fluid into the urethra" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:78062]	Show Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0002840	abnormal lens fibers morphology	"structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk Genetic Background: involves: 129P2/OlaHsd * C57BL/6N Allelic Composition: Fgf10^Mhdaaey17/Fgf10⁺ Genetic Background: involves: C3HeB/FeJ * C57BL/6
MP:0002925	abnormal cardiovascular development	"aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0003014	abnormal kidney medulla morphology	"anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
MP:0003124	hypospadia	"a urethral opening located closer to the base of the penis and not at the tip" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0003162	reduced size of lateral semicircular canal		Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003163	absent posterior semicircular canal		Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003165	absent superior semicircular canal		Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003209	abnormal pulmonary elastic fiber morphology	"malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA
MP:0003237	abnormal lens epithelium morphology	"malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]	Show Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
MP:0003334	pancreatic fibrosis	"invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0003339	decreased number of pancreatic beta cells	"fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0003358	abnormal hypaxial muscle morphology	"malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0003595	epididymal cyst	"benign growths present in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0003642	absent seminal gland	"absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0003649	reduced right ventricle		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0003755	abnormal palate	"anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0003760	short palate	"abnormally decreased length to the roof of the oral cavity" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0003809	abnormal hair shaft morphology	"irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0003827	abnormal Wolffian duct morphology	"malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0003938	abnormal ear development	"developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc4a1^tm1Llp/Slc4a1^wan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
MP:0004113	abnormal aortic arch morphology	"structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0004140	abnormal chief cell morphology	"malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0004247	small pancreas	"decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0004249	abnormal crista ampullaris morphology	"anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004309	absent otic vesicle	"absence of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0004310	small otic vesicle	"reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng,Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10⁺ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf3^tm1Mrc/Fgf3⁺,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0004313	absent vestibulocochlear ganglion	"absence of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng,Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0004317	small saccule	"reduced size of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004352	absent humerus	"missing one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0004360	absent ulna	"missing the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0004509	abnormal pelvic girdle bone morphology	"any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0004515	abnormal vestibular hair cell stereociliary bundle morphology	"any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004573	absent limb buds	"missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^ptls/Fgf10^ptls Genetic Background: involves: C57BL/6 * FVB/N
MP:0004830	short incisors	"reduced length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0004842	abnormal large intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0005287	narrow eye opening	"less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]	Show Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk Genetic Background: involves: 129P2/OlaHsd * C57BL/6N Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0005314	absent thyroid gland	" missing endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0005315	absent pituitary gland	"missing gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0005358	abnormal incisor morphology	"structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA
MP:0005650	abnormal limb bud morphology	"aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0006027	impaired alveologenesis	"a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0006030	abnormal otic vesicle formation	"anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
MP:0006065	abnormal heart position	"the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0006072	abnormal retinal apoptosis	"increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]	Show Allelic Composition: Fgf10^Mhdaaey17/Fgf10⁺ Genetic Background: involves: C3HeB/FeJ * C57BL/6
MP:0006090	abnormal utricle morphology	"malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006243	abnormal pupil dilation reaction to light	"the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0006279	abnormal limb development	"anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0006285	absent inner ear	"absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
MP:0006288	small otic capsule	"reduced size of the cartilage or bony capsule surrounding the inner ear mechanism" [J:59285, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0006354	abnormal fourth branchial arch artery morphology	"any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006355	abnormal sixth branchial arch artery morphology	"any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006356	abnormal third branchial arch artery morphology	"any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006402	small molars	"reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0008320	absent adenohypophysis	"absence of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0008786	abnormal hindgut morphology	"any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0008825	abnormal cardiac epithelial to mesenchymal transition	"anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0008904	abnormal mammary fat pad morphology	"any structural anomaly of the encapsulated adipose tissue associated with the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0009479	abnormal cecum development	"malformation or aberrant differentiation of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^tm1Sms,Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0009509	absent rectum	"absence or loss of the terminal portion of the intestinal tube adjacent to the anus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0009510	cecal atresia	"congenital blockage or absence of the lumen of the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^{tm1.1(cre/ERT2)Sbel} Genetic Background: involves: 129 * C57BL/6J
MP:0009520	decreased submandibular gland size	"reduced size of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cer1^tm1Bhr/Cer1^tm1Bhr,Lefty1^tm1Sla/Lefty1^tm1Sla Genetic Background: involves: 129S7/SvEvBrd * CD-1
MP:0009522	submandibular gland hypoplasia	"underdevelopment or reduced size of either of the large major salivary glands situated beneath the mandible, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Ska/Fgf10⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Wss/Fgf10⁺ Genetic Background: involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
MP:0009524	absent submandibular gland	"absence of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0009525	abnormal submandibular duct morphology	"any strucutral anomaly of the duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Wss/Fgf10⁺,Fgfr2^tm2Dsn/Fgfr2⁺,Tg(Pgk1-cre)1Lni/0 Genetic Background: involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
MP:0009571	abnormal right lung accessory lobe morphology		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0009572	abnormal right lung cranial lobe morphology		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0009573	abnormal right lung middle lobe morphology		Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0009655	abnormal secondary palate development	"any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0009884	palatal shelf fusion with tongue or mandible	"palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues" [PMID:16680722]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0010116	abnormal primitive urogenital sinus morphology	"any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0010465	aberrant origin of the right subclavian artery	"the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0010489	abnormal heart atrium auricular region morphology	"any structural anomaly of the small conical pouch projections located on the upper anterior portion of each atrium of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0010521	absent pulmonary artery	"absence of the artery that arises from the right ventricle and conveys unaerated blood to the lungs" [MESH:A07.231.114.715]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0010646	absent pulmonary vein	"absence of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0010681	abnormal hair follicle bulb morphology	"any structural anomaly of the thickened portion of the proximal portion of the hair follicle that contains rapidly proliferating matrix cells, melanocytes and outer root sheath cells" [PMID:19211055]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0010794	abnormal stomach submucosa morphology	"any structural anomaly of the fibrous connective tissue layer beneath the stomach mucosa" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0010906	abnormal lung bud morphology	"any structural anomaly of the primary outgrowth of the embryonic trachea i.e. blunt end of the respiratory diverticulum which grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the anlage of a primary bronchus and all its branches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^tm1Sms,Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0010907	absent lung buds	"absence of the blunt end of the respiratory diverticulum which normally grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the origins of the bronchial tree" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^{tm1.1(cre/ERT2)Sbel} Genetic Background: involves: 129 * C57BL/6J
MP:0010975	abnormal lung lobe morphology	"any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0010976	small lung lobe	"reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0011025	abnormal branching involved in trachea morphogenesis	"anomaly in the process in which the two main branches of the trachea is generated and organized" [MGI:csmith]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0011028	impaired branching involved in bronchus morphogenesis		Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Sms,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
MP:0011030	impaired branching involved in preterminal bronchiole morphogenesis		Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0011064	abnormal vestibular hair cell kinocilium morphology	"any structural anomaly of the nonmotile primary cilium that is found at the apical surface of vestibular hair cells" [GO:0060091, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ube2n^tm1Aki/Ube2n^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Fgf10^Mhdaaey17/Fgf10^Mhdaaey17 Genetic Background: C3HeB/FeJ-Fgf10^Mhdaaey17
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng,Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0011195	increased hair follicle apoptosis	"greater than expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops" [MGI:mnk]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011305	dilated kidney calyx	"an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011332	abnormal kidney outer medulla morphology	"any structural anomaly of the outer medullary region of the adult kidney containing the short Loops of Henle and collecting ducts" [MGI:csmith, PMID:20614633]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011333	abnormal kidney inner medulla morphology	"any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle" [MGI:csmith, PMID:20614633]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011457	abnormal metanephric ureteric bud development	"any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros" [GO:0035502]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011759	absent Rathke s pouch	"absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011884	absent colon	"absence of the portion of the large intestine between the cecum and the rectum" [MGI:Colin_McKerlie]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0012729	abnormal common carotid artery morphology	"any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0012752	abnormal cardiac neural crest cell migration	"any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0013264	tongue ankylosis	"partial or complete fusion or adherence of the tongue to the floor of the mouth, resulting in varying degrees of restricted tongue mobility; partial ankyloglossia (aka tongue-tie) is caused by a lingual frenulum that is abnormally short or is attached too close to the tip of the tongue; in complete ankyloglossia the tongue is tethered to the floor of the mouth" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0013268	second pharyngeal arch hypoplasia	"underdevelopment or reduced size of the second pharyngeal arch, usually due to reduced cell number" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0013269	third pharyngeal arch hypoplasia	"underdevelopment or reduced size of the third pharyngeal arch, usually due to reduced cell number" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0013338	abnormal neurohypophysis development	"aberrant formation or incomplete differentiation of the posterior lobe of the pituitary gland which develops as a neurohypophyseal bud, a depression in the neuroectoderm of the floor of the hypothalamus; the infundibulum, another diverticulum from the inferior aspect of the diencephalon, develops as an outgrowth of the neurohypophyseal bud and connects the neurohypophysis to the hypothalamus; the neurohypophysis develops as the infundibulum grows inferiorly from the diencephalon to meet the developing adenohypophysis (anterior pituitary lobe); the fully developed neurohypophysis consists of the infundibulum and the pars nervosa; the neural connection between the hypothalamus and pars nervosa is through the hypothalamohypophyseal tract that develops within the infundibulum" [MGI:Anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0013352	abnormal Rathke s pouch apoptosis	"any change in the timing or number of Rathke s pouch cells undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0013445	Harderian gland atrophy	"acquired diminution of the size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]	Show Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
MP:0013495	decreased trachea gland number	"fewer than normal numbers of the tubuloacinar seromucous glands which are principally located in the submucosa of the trachea, open into the tracheal lumen through short ducts, and secrete mucus, lysozyme, defensins, and other agents that help protect the lungs from particles and infectious agents; in the mouse, they are restricted to the upper trachea, more specifically to the regions between the first few cartilage rings, with the precise distribution depending on genetic background" [http://medical-dictionary.thefreedictionary.com/tracheal+glands, ISBN:1451113412, MGI:Anna, PMID:15973734]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0013531	abnormal periderm development	"abnormal formation of the outermost layer of the bilaminar embryonic/fetal epidermis; periderm cells emerge at approximately E9.5 and form simple squamous epithelium, the most superficial embryonic layer; these cells form the first, but temporary, embryonic permeability barrier, and are replaced by the cornified envelope, that forms during keratinocyte stratification, by E16.5" [http://discovery.lifemapsc.com/in-vivo-development/epidermis/embryonic-epidermis/periderm-cells, MGI:Anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0013580	abnormal nasal gland morphology	"any structural anomaly of any of the seromucous glands found in the respiratory region of the nasal mucous membrane, including anterior serous glands, seromucous glands, and Bowman glands" [http://en.wikipedia.org/wiki/Nasal_glands, MGI:Anna, UBERON:0012278]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ Allelic Composition: Fgf10^tm1Wss/Fgf10⁺ Genetic Background: involves: 129X1/SvJ
MP:0013582	abnormal lateral nasal gland morphology	"any structural anomaly of the lateral nasal glands (the largest nasal secretory glands in rodents) which surround the maxillary sinus located in the lateral wall adjacent to each nasal passage and are characterized by cytologic features similar to those described for the major serous salivary glands; secretory contents of the LNG drain into the nasal vestibule; the LNG is a major site for the synthesis and secretion of odorant-binding proteins that serve as odorant carriers in nasal mucus; it also, synthesizes large amounts of immunoglobulin A, which is important for immune defense of the upper respiratory tract, and testosterone and salivary androgen-binding proteins, which are likely important in olfaction and reproductive behavior" [ISBN:0080454321, ISBN:0123813611, MGI:Anna]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ Allelic Composition: Fgf10^tm1Wss/Fgf10⁺ Genetic Background: involves: 129X1/SvJ
MP:0013721	abnormal mammary placode morphology	"any structural anomaly of the transient lens-shaped thickening of surface ectoderm that will give rise to the mammary bud proper; in mouse, five pairs of symmetrically positioned mammary placodes (three thoracic and two inguinal) form at reproducible locations along the mammary line at E11.5; the individual pairs develop asynchronously and in a distinct order; pair 3 is first, followed by pair 4, then by pairs 1 and 5 (which develop together), and finally by pair 2; the orientation of placodal cells is not uniform, suggesting that placodes are formed by migration of cells from the mammary line; between E11.5 and E12.5, each mammary placode expands and invaginates into the underlying mesenchyme to form an early bulb-shaped mammary bud " [PMID:16168142, PMID:20484386]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck} Genetic Background: involves: C57BL/6 * CBA
MP:0013766	absent palatal rugae	"absence of the transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species" [MGI:Anna, PMID:19087265]	Show Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129X1/SvJ
MP:0013956	decreased colon length	"reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000048373	Fgfbp1 / O70514 / Fibroblast growth factor-binding protein 1 / Q14512*	/ complex / reaction

1 s.

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