Manteia

ENSMUSG00000031074

Mus musculus

Features

Gene ID:	ENSMUSG00000031074

Biological name :	Fgf3

Synonyms :	Fgf3 / fibroblast growth factor 3

Possible biological names infered from orthology :	P11487

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	F5
Gene start:	144838083
Gene end:	144844436

Corresponding Affymetrix probe sets:	10559361 (MoGene1.0st) 1422923_at (Mouse Genome 430 2.0 Array) 1441350_at (Mouse Genome 430 2.0 Array) 1441914_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000115205 Ensembl peptide - ENSMUSP00000101518 NCBI entrez gene - 14174 See in Manteia. MGI - MGI:95517 RefSeq - NM_008007 RefSeq - XM_011241980 RefSeq Peptide - NP_032033 swissprot - D3YWD4 swissprot - Q0VG15 Ensembl - ENSMUSG00000031074

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fgf3	ENSDARG00000101540	Danio rerio
FGF3	ENSGALG00000026853	Gallus gallus
FGF3	ENSG00000186895	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*	ENSMUSG00000021732	32
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*	ENSMUSG00000031603	30
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*	ENSMUSG00000029337	29
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*	ENSMUSG00000031230	29
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*	ENSMUSG00000021974	28
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*	ENSMUSG00000020327	28
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*	ENSMUSG00000027208	27
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*	ENSMUSG00000000183	26
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*	ENSMUSG00000031137	24
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*	ENSMUSG00000022523	23
Fgf14 / fibroblast growth factor 14 / Q92915*	ENSMUSG00000025551	23
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*	ENSMUSG00000050917	22
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*	ENSMUSG00000042826	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF
IPR028232	Fibroblast growth factor 3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0055026	negative regulation of cardiac muscle tissue development	IEA
cellular_component	GO:0005576	extracellular region	IEA
molecular_function	GO:0005104	fibroblast growth factor receptor binding	IEA
molecular_function	GO:0008083	growth factor activity	IEA

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: F9^tm1Dws/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000034	abnormal vestibule morphology	"malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000035	abnormal membranous labyrinth	"malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000041	absent endolymphatic duct	"missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000549	absent limbs	"missing extremities" [J:51966, J:50768]	Show Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: F9^tm1Dws/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm2.1Sms/Fgf3^tm2.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0000588	thick tail	"a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc4a1^tm1Llp/Slc4a1^wan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Slc4a1^tm1Llp/Slc4a1^wan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd,Fgf4^tm1.1Lwd/Fgf4^tm1.1Lwd Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf3^{tm4b(EUCOMM)Hmgu}/Fgf3^{tm4b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Fgf3^{tm4b(EUCOMM)Hmgu}/Bay
MP:0001081	abnormal cranial ganglia morphology	"any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd,Fgf4^tm1.1Lwd/Fgf4^tm1.1Lwd Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: F9^tm1Dws/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001404	no spontaneous movement	"failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Fgf3^{tm4b(EUCOMM)Hmgu}/Fgf3^{tm4b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Fgf3^{tm4b(EUCOMM)Hmgu}/Bay
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: F9^tm1Dws/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: F9^tm1Dws/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001539	decreased number of caudal vertebrae	"reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd,Fgf4^tm1.1Lwd/Fgf4^tm1.2Lwd Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^{tm4b(EUCOMM)Hmgu}/Fgf3^{tm4b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Fgf3^{tm4b(EUCOMM)Hmgu}/Bay
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002102	abnormal ear morphology	"structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc4a1^tm1Llp/Slc4a1^wan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J Allelic Composition: Fgf3^{tm4b(EUCOMM)Hmgu}/Fgf3^{tm4b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Fgf3^{tm4b(EUCOMM)Hmgu}/Bay
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: F9^tm1Dws/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm2.1Sms/Fgf3^tm2.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Fgf10^tm1.2Sms/Fgf10^tm1.2Sms,Fgf3^tm1.2Sms/Fgf3^tm1.2Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0002428	abnormal semicircular canal	"anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002759	abnormal caudal vertebrae morphology	"malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm2Mrc/Fgf3^tm2Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003148	reduced cochlear coiling	"a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003163	absent posterior semicircular canal		Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003165	absent superior semicircular canal		Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003168	abnormal scala vestibuli morphology	"any malformation or absence of the division of the spiral canal of the cochlea lying on the apical side of the spiral lamina and vestibular membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003169	abnormal scala media morphology	"any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003637	cochlear ganglion hypoplasia	"reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003703	abnormal vestibulocochlear ganglion morphology	"malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003938	abnormal ear development	"developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc4a1^tm1Llp/Slc4a1^wan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004309	absent otic vesicle	"absence of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0004310	small otic vesicle	"reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc4a1^tm1Llp/Slc4a1^wan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng,Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10⁺ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf3^tm1Mrc/Fgf3⁺,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf10^tm1.1Sms/Fgf10^tm1.1Sms,Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
MP:0004313	absent vestibulocochlear ganglion	"absence of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng,Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0004493	dilated cochlea	"the luminal space of the cochlea is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004619	caudal vertebral fusion	"the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004923	absent common crus	"absence of the united, nonampullary ends of the superior and posterior semicircular ducts in the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005191	head tilt	"condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd,Fgf4^tm1.1Lwd/Fgf4^tm1.1Lwd Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J
MP:0006013	absent endolymphatic sac	"absence of the dilated blind extremity of the endolymphatic duct, which lies external to the dura on the posterior aspect of the petrous part of the temporal bone" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:1776:]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006030	abnormal otic vesicle formation	"anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0006089	abnormal saccule morphology	"malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006090	abnormal utricle morphology	"malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006285	absent inner ear	"absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc,Fgf10^tm1Wss/Fgf10^tm1Wss Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
MP:0006358	absent pinna reflex	"complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008065	short endolymphatic duct	"length reduction or truncation of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008309	dilated scala media	"stretched or widened aperture of the luminal space of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng,Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf3^{tm4b(EUCOMM)Hmgu}/Fgf3^{tm4b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Fgf3^{tm4b(EUCOMM)Hmgu}/Bay
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0012173	short rostral-caudal axis	"length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]	Show Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd,Fgf4^tm1.1Lwd/Fgf4^tm1.2Lwd Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J
MP:0012182	abnormal presomitic mesoderm morphology	"any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]	Show Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd,Fgf4^tm1.1Lwd/Fgf4^tm1.1Lwd Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd,Fgf4^tm1.1Lwd/Fgf4^tm1.2Lwd Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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