Manteia - Molecule gene

ENSMUSG00000025551

Mus musculus

Features

Gene ID:	ENSMUSG00000025551

Biological name :	Fgf14

Synonyms :	Fgf14 / fibroblast growth factor 14

Possible biological names infered from orthology :	Q92915

Species:	Mus musculus

Chr. number:	14
Strand:	-1
Band:	E5
Gene start:	123977907
Gene end:	124677127

Corresponding Affymetrix probe sets:	10422585 (MoGene1.0st) 1435747_at (Mouse Genome 430 2.0 Array) 1447480_at (Mouse Genome 430 2.0 Array) 1449958_a_at (Mouse Genome 430 2.0 Array) 1458830_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000026631 Ensembl peptide - ENSMUSP00000093185 NCBI entrez gene - 14169 See in Manteia. MGI - MGI:109189 RefSeq - XM_017315845 RefSeq - NM_010201 RefSeq - NM_207667 RefSeq - XM_011244952 RefSeq Peptide - NP_997550 RefSeq Peptide - NP_034331 swissprot - O89096 swissprot - A0A0R4J063 Ensembl - ENSMUSG00000025551

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fgf14	ENSDARG00000040982	Danio rerio
FGF14	ENSGALG00000016866	Gallus gallus
FGF14	ENSG00000102466	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*	ENSMUSG00000022523	58
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*	ENSMUSG00000031137	55
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*	ENSMUSG00000042826	48
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*	ENSMUSG00000021974	25
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*	ENSMUSG00000031603	25
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*	ENSMUSG00000031230	24
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*	ENSMUSG00000000183	23
Fgf3 / fibroblast growth factor 3 / P11487*	ENSMUSG00000031074	22
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*	ENSMUSG00000050917	22
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*	ENSMUSG00000029337	22
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*	ENSMUSG00000027208	20
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*	ENSMUSG00000020327	17
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*	ENSMUSG00000021732	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF
IPR028284	Fibroblast growth factor 14

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
cellular_component	GO:0005576	extracellular region	IEA
molecular_function	GO:0008083	growth factor activity	IEA

Pathways (from Reactome)

Pathway description

Phase 0 - rapid depolarisation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000746	weakness	"state of being infirm or less strong than littermates" [J:45400]	Show Allelic Composition: Chn1^tm2Abet/Chn1^tm2Abet Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000811	hippocampal neuron degeneration	"a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]	Show Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^tm1Sms,Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^tm1Sms,Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001362	abnormal anxiety-related response	"altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Bmpr2^tm1.1Enl/Bmpr2^tm1.2Enl,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J
MP:0001363	increased anxiety-related response	"when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]	Show Allelic Composition: Bmpr2^tm1.1Enl/Bmpr2^tm1.2Enl,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Bmpr2^tm1.1Enl/Bmpr2^tm1.2Enl,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor Allelic Composition: Fgf12^tm1Gol/Fgf12^tm1Gol,Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor Allelic Composition: Fgf12^tm1Gol/Fgf12^tm1Gol,Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: 129S6/SvEvTac * FVB/N
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor Allelic Composition: Fgf12^tm1Gol/Fgf12^tm1Gol,Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001413	abnormal response to new environment	"altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Chn1^tm2Abet/Chn1^tm2Abet Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0001415	increased exploration in new environment	"greater amount of time spent investigating new location" [J:28825]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: 129S6/SvEvTac * FVB/N
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo
MP:0001473	reduced long term potentiation	"less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]	Show Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0001504	abnormal posture	"atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001522	impaired swimming	"reduced ability or inability to swim" [J:45446, J:39081]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0002175	low brain weight	"lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0002206	abnormal CNS synaptic transmission	"defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf12^tm1Gol/Fgf12^tm1Gol,Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002272	abnormal nervous system electrophysiology	"anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002878	abnormal corticospinal tract	"anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0003214	neurofibrillary tangles	"dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: 129S6/SvEvTac * FVB/N
MP:0003224	neuron degeneration	"a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0003313	abnormal locomotor activation	"altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0003484	abnormal channel response	"anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: Fgf12^tm1Gol/Fgf12^tm1Gol,Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0004250	tau protein deposits	"formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: 129S6/SvEvTac * FVB/N
MP:0005323	dystonia	"impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0008263	abnormal hippocampus CA1 region morphology		Show Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo
MP:0008414	abnormal spatial reference memory	"anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N
MP:0009454	impaired contextual conditioning	"decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: 129S6/SvEvTac * FVB/N
MP:0009456	impaired cued conditioning behavior	"decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: 129S6/SvEvTac * FVB/N
MP:0009971	decreased hippocampus pyramidal cell number	"decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺,Tmc1m4^DBA/2J/? Genetic Background: involves: C3HeB/FeJ * DBA/2J Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor Allelic Composition: Fgf12^tm1Gol/Fgf12^tm1Gol,Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0012307	impaired spatial learning	"impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]	Show Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor Genetic Background: B6.129S6-Fgf14^tm1Dor
MP:0012508	forebrain atrophy	"acquired diminution of the size of the forebrain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14^{Tg(tetO-MAPTP301L)4510Kha}/Fgf14⁺ Genetic Background:* involves: FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr