ENSMUSG00000031603


Mus musculus

Features
Gene ID: ENSMUSG00000031603
  
Biological name :Fgf20
  
Synonyms : Fgf20 / Fibroblast growth factor 20 / Q9ESL9
  
Possible biological names infered from orthology : Q9NP95
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A4
Gene start: 40279166
Gene end: 40308331
  
Corresponding Affymetrix probe sets: 10578281 (MoGene1.0st)   1421677_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112756
Ensembl peptide - ENSMUSP00000034014
NCBI entrez gene - 80857     See in Manteia.
MGI - MGI:1891346
RefSeq - NM_030610
RefSeq Peptide - NP_085113
swissprot - D3YU10
swissprot - Q9ESL9
Ensembl - ENSMUSG00000031603
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf20aENSDARG00000007356Danio rerio
 fgf20bENSDARG00000086070Danio rerio
 FGF20ENSGALG00000013663Gallus gallus
 FGF20ENSG00000078579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197471
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123063
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107435
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*ENSMUSG0000002933733
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*ENSMUSG0000002032733
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*ENSMUSG0000002720832
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*ENSMUSG0000005091731
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*ENSMUSG0000000018331
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*ENSMUSG0000003113731
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555130
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173230
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*ENSMUSG0000002252329
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282629


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028291  Fibroblast growth factor 20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045664 regulation of neuron differentiation IMP
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IGI
 biological_processGO:0060113 inner ear receptor cell differentiation IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0090722 receptor-receptor interaction IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0003825 abnormal pillar cell morphology "abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0004497 decreased supporting cell number "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0004589 abnormal cochlear hair cell development "atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0006365 absent guard hair "absence of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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