ENSMUSG00000022523


Mus musculus

Features
Gene ID: ENSMUSG00000022523
  
Biological name :Fgf12
  
Synonyms : Fgf12 / Fibroblast growth factor 12 / P61329
  
Possible biological names infered from orthology : P61328
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B2
Gene start: 28160120
Gene end: 28445227
  
Corresponding Affymetrix probe sets: 10438801 (MoGene1.0st)   1436432_at (Mouse Genome 430 2.0 Array)   1440270_at (Mouse Genome 430 2.0 Array)   1451693_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097601
NCBI entrez gene - 14167     See in Manteia.
MGI - MGI:109183
RefSeq - NM_183064
RefSeq - XM_006521793
RefSeq - NM_001276419
RefSeq - NM_010199
RefSeq Peptide - NP_034329
RefSeq Peptide - NP_898887
RefSeq Peptide - NP_001263348
swissprot - P61329
Ensembl - ENSMUSG00000022523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf12aENSDARG00000027957Danio rerio
 fgf12bENSDARG00000113525Danio rerio
 FGF12ENSGALG00000036971Gallus gallus
 FGF12ENSG00000114279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555160
Fgf13 / P70377 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / Q92913* / fibroblast growth factor 13*ENSMUSG0000003113760
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282656
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*ENSMUSG0000003160326
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197426
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123025
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*ENSMUSG0000000018323
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107423
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*ENSMUSG0000005091722
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*ENSMUSG0000002933721
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173221
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*ENSMUSG0000002720820
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*ENSMUSG0000002032719


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028254  Fibroblast growth factor 12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003254 regulation of membrane depolarization IEA
 biological_processGO:0007254 JNK cascade ISO
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0008344 adult locomotory behavior IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IGI
 biological_processGO:0050905 neuromuscular process IGI
 biological_processGO:0098908 regulation of neuronal action potential IEA
 biological_processGO:1902305 regulation of sodium ion transmembrane transport IEA
 biological_processGO:1905150 regulation of voltage-gated sodium channel activity IEA
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IEA
 biological_processGO:2001258 negative regulation of cation channel activity IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding ISO
 molecular_functionGO:0017080 sodium channel regulator activity IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Chn1tm2Abet/Chn1tm2Abet
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Fgf12tm1Gol/Fgf12tm1Gol,Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Fgf12tm1Gol/Fgf12tm1Gol,Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Fgf12tm1Gol/Fgf12tm1Gol,Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Chn1tm2Abet/Chn1tm2Abet
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgf12tm1Gol/Fgf12tm1Gol,Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Fgf12tm1Gol/Fgf12tm1Gol,Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Fgf12tm1Gol/Fgf12tm1Gol,Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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