ENSMUSG00000031137


Mus musculus

Features
Gene ID: ENSMUSG00000031137
  
Biological name :Fgf13
  
Synonyms : Fgf13 / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA. / P70377
  
Possible biological names infered from orthology : fibroblast growth factor 13 / Q92913
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A6
Gene start: 59062145
Gene end: 59568071
  
Corresponding Affymetrix probe sets: 10604751 (MoGene1.0st)   1418497_at (Mouse Genome 430 2.0 Array)   1418498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113639
Ensembl peptide - ENSMUSP00000113206
Ensembl peptide - ENSMUSP00000114905
Ensembl peptide - ENSMUSP00000119897
Ensembl peptide - ENSMUSP00000115765
Ensembl peptide - ENSMUSP00000033473
NCBI entrez gene - 14168     See in Manteia.
MGI - MGI:109178
RefSeq - XM_006527799
RefSeq - NM_001290414
RefSeq - NM_001290415
RefSeq - NM_001356335
RefSeq - NM_010200
RefSeq - XM_006527793
RefSeq - XM_006527795
RefSeq - XM_006527796
RefSeq - XM_006527797
RefSeq Peptide - NP_001277343
RefSeq Peptide - NP_001343264
RefSeq Peptide - NP_034330
RefSeq Peptide - NP_001277344
swissprot - P70377
swissprot - A0A067XG51
swissprot - B1AU23
swissprot - B1AU22
swissprot - B1AU20
Ensembl - ENSMUSG00000031137
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf13aENSDARG00000035056Danio rerio
 fgf13bENSDARG00000056633Danio rerio
 FGF13ENSGALG00000006508Gallus gallus
 FGF13ENSG00000129682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf12 / P61329 / Fibroblast growth factor 12 / P61328*ENSMUSG0000002252360
Fgf14 / fibroblast growth factor 14 / Q92915*ENSMUSG0000002555156
Fgf11 / P70378 / Fibroblast growth factor 11 / Q92914*ENSMUSG0000004282650
Fgf20 / Q9ESL9 / Fibroblast growth factor 20 / Q9NP95*ENSMUSG0000003160327
Fgf9 / P54130 / Fibroblast growth factor 9 / P31371*ENSMUSG0000002197427
Fgf3 / fibroblast growth factor 3 / P11487*ENSMUSG0000003107424
Fgf16 / Q9ESL8 / Fibroblast growth factor 16 / O43320*ENSMUSG0000003123024
Fgf6 / P21658 / Fibroblast growth factor 6 / P10767*ENSMUSG0000000018323
Fgf5 / P15656 / Fibroblast growth factor 5 / P12034*ENSMUSG0000002933722
Fgf10 / O35565 / Fibroblast growth factor 10 / O15520*ENSMUSG0000002173222
Fgf4 / P11403 / Fibroblast growth factor 4 / P08620*ENSMUSG0000005091721
Fgf7 / P36363 / Fibroblast growth factor 7 / P21781*ENSMUSG0000002720821
Fgf22 / Q9ESS2 / Fibroblast growth factor 22 / Q9HCT0*ENSMUSG0000002032717


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028279  Fibroblast growth factor 13


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0006814 sodium ion transport IMP
 biological_processGO:0007026 negative regulation of microtubule depolymerization IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0046785 microtubule polymerization IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
 biological_processGO:1990834 response to odorant IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IMP
 molecular_functionGO:0030295 protein kinase activator activity ISO
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0048487 beta-tubulin binding IDA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Fgf13tm1Xuzh/Fgf13tm1Xuzh,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
Show

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Fgf13tm1Xuzh/Fgf13tm1Xuzh,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Fgf13tm1Xuzh/Fgf13tm1Xuzh,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgf13tm1Xuzh/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fgf13tm1Xuzh/Y,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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