ENSDARG00000030932


Danio rerio

Features
Gene ID: ENSDARG00000030932
  
Biological name :fgf10a
  
Synonyms : fgf10a / fibroblast growth factor 10a
  
Possible biological names infered from orthology : FGF10 / fibroblast growth factor 10 / O15520 / O35565
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 19635486
Gene end: 19683168
  
Corresponding Affymetrix probe sets: Dr.8853.1.S1_at (Zebrafish Array)   NM_182870_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000048580
Ensembl peptide - ENSDARP00000152426
NCBI entrez gene - 359830     See in Manteia.
RefSeq - NM_182870
RefSeq Peptide - NP_878290
swissprot - Q8AY90
ZFIN ID - ZDB-GENE-030715-1
Ensembl - ENSDARG00000030932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF10ENSGALG00000014872Gallus gallus
 FGF10ENSG00000070193Homo sapiens
 Fgf10ENSMUSG00000021732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*ENSDARG0000010047556
fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*ENSDARG0000007651044
fgf3 / P48802 / fibroblast growth factor 3 / P11487*ENSDARG0000010154036
fgf7 / fibroblast growth factor 7 / P21781*ENSDARG0000005938731
fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000008607030
fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000000735628
fgf4 / fibroblast growth factor 4 / P08620* / P11403*ENSDARG0000010523027
fgf6b / fibroblast growth factor 6b / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000004585627
fgf16 / Q2HXK8 / fibroblast growth factor 16 / O43320* / Q9ESL8*ENSDARG0000004223327
fgf6a / fibroblast growth factor 6a / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000000935126
fgf5 / fibroblast growth factor 5 / P12034* / P15656*ENSDARG0000003537726
fgf13a / fibroblast growth factor 13a / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000003505625
fgf13b / fibroblast growth factor 13b / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000005663324
fgf12a / fibroblast growth factor 12a / FGF12* / P61329* / P61328* / fibroblast growth factor 12*ENSDARG0000002795723
fgf11b / fibroblast growth factor 11b / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000004390722
fgf9 / fibroblast growth factor 9ENSDARG0000007862521
fgf14 / fibroblast growth factor 14 / Q92915*ENSDARG0000004098221
fgf12b / fibroblast growth factor 12b / FGF12* / P61328* / fibroblast growth factor 12*ENSDARG0000011352521
fgf11a / fibroblast growth factor 11a / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000006966220


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028252  Fibroblast growth factor 10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0048794 swim bladder development IMP
 biological_processGO:0048919 posterior lateral line neuromast development IMP
 biological_processGO:0048920 posterior lateral line neuromast primordium migration IGI
 biological_processGO:0060022 hard palate development IMP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta increased amount , abnormal
dorsal aorta mislocalised , abnormal
Show

 ZFA:0000076 swim bladder swim bladder decreased size , abnormal
swim bladder quality , abnormal
swim bladder epithelium decreased size , abnormal
Show

 ZFA:0000108 fin fin decreased size , abnormal
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 ZFA:0000561 parasphenoid parasphenoid shape , abnormal
parasphenoid decreased length , abnormal
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 ZFA:0001100 hepatic duct hepatic duct morphology , abnormal
hepatic duct decreased size , abnormal
hepatic duct aplastic , abnormal
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 ZFA:0001114 head head lacks all parts of type facial ganglion , abnormal
head lacks all parts of type glossopharyngeal ganglion , abnormal
head lacks all parts of type vagal ganglion 1 , abnormal
head lacks all parts of type vagal ganglion 2 , abnormal
head lacks all parts of type vagal ganglion 3 , abnormal
head lacks all parts of type vagal ganglion 4 , abnormal
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 ZFA:0001115 trunk trunk increased amount , abnormal
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 ZFA:0001161 pectoral fin pectoral fin absent , abnormal
pectoral fin aplastic , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage shape , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton shape , abnormal
mandibular arch skeleton decreased length , abnormal
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 ZFA:0001260 endocrine pancreas endocrine pancreas mislocalised , abnormal
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 ZFA:0001295 facial placode facial placode poorly differentiated , abnormal
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 ZFA:0001296 glossopharyngeal placode glossopharyngeal placode poorly differentiated , abnormal
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 ZFA:0001297 vagal placode 1 vagal placode 1 poorly differentiated , abnormal
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 ZFA:0001298 vagal placode 2 vagal placode 2 poorly differentiated , abnormal
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 ZFA:0001299 vagal placode 3 vagal placode 3 poorly differentiated , abnormal
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 ZFA:0001300 vagal placode 4 vagal placode 4 neuroblast (sensu Vertebrata) mislocalised ventrally , abnormal
vagal placode 4 poorly differentiated , abnormal
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 ZFA:0001338 intestine intestine decreased width , abnormal
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 ZFA:0001372 pancreatic duct pancreatic duct aplastic , abnormal
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 ZFA:0001383 fin bud fin bud aplastic , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage shape , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased length , abnormal
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 ZFA:0001499 esophageal epithelium esophageal epithelium decreased size , abnormal
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 ZFA:0001507 trabecula cranii trabecula cranii shape , abnormal
trabecula cranii decreased length , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta increased amount , abnormal
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 ZFA:0005346 extrapancreatic duct extrapancreatic duct physical object quality , abnormal
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 ZFA:0005509 palate palate shape , abnormal
palate square , abnormal
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 ZFA:0009096 endocrine cell endocrine cell mislocalised , abnormal
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 ZFA:0009111 hepatocyte hepatocyte mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000076895 flrt3 / fibronectin leucine rich transmembrane 3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3* / Leucine-rich repeat transmembrane protein FLRT3 *  / reaction / complex
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000039963 fgfbp1b / fibroblast growth factor binding protein 1b / Q14512* / FGFBP1* / O70514* / fibroblast growth factor binding protein 1*  / reaction / complex
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / reaction / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000075597 flrt1b / fibronectin leucine rich transmembrane protein 1b / FLRT1* / Q6RKD8* / Q9NZU1* / fibronectin leucine rich transmembrane protein 1* / Leucine-rich repeat transmembrane protein FLRT1 *  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000079355 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000097299 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000091660 fgfbp1b / fibroblast growth factor binding protein 1b / FGFBP1* / Q14512* / fibroblast growth factor binding protein 1*  / reaction / complex
 ENSDARG00000032617 fgfrl1a / fibroblast growth factor receptor like 1a / Q91V87* / FGFRL1* / Q8N441* / fibroblast growth factor receptor like 1*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / complex
 ENSDARG00000105230 fgf4 / fibroblast growth factor 4 / P08620* / P11403*  / reaction / complex
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / reaction / complex






 

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