ENSDARG00000075456


Danio rerio

Features
Gene ID: ENSDARG00000075456
  
Biological name :pik3ca
  
Synonyms : phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / pik3ca
  
Possible biological names infered from orthology : P42336 / P42337 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 34488869
Gene end: 34522249
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000103176
Ensembl peptide - ENSDARP00000138914
Ensembl peptide - ENSDARP00000148626
NCBI entrez gene - 561737     See in Manteia.
swissprot - F1QAD7
ZFIN ID - ZDB-GENE-130409-1
Ensembl - ENSDARG00000075456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIK3CAENSGALG00000008934Gallus gallus
 P42336ENSG00000121879Homo sapiens
 P42337ENSMUSG00000027665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:158659ENSDARG0000006059782
pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *ENSDARG0000007525339
pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta / O00329*ENSDARG0000000325039
pik3cg / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma / P48736* / Q9JHG7* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform *ENSDARG0000001775729
si:rp71-17i16.5ENSDARG0000003752727
pik3c2a / phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha / O00443*ENSDARG0000006084123
pik3c2b / phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta / O00750*ENSDARG0000008692723
pik3c2g / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma / O75747*ENSDARG0000009980318
pik3c3 / phosphatidylinositol 3-kinase, catalytic subunit type 3 / Q6PF93* / Q8NEB9*ENSDARG0000005482917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation IBA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048696 regulation of collateral sprouting in absence of injury IMP
 biological_processGO:0060326 cell chemotaxis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005943 phosphatidylinositol 3-kinase complex, class IA IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Role of phospholipids in phagocytosis
Tie2 Signaling
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
G alpha (q) signalling events
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon decreased branchiness , abnormal
retinal ganglion cell collateral sprouting in absence of injury decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000007356 fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / reaction / complex
 ENSDARG00000043317 kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000004782 fgfr3 / fibroblast growth factor receptor 3 / P22607*  / reaction / complex
 ENSDARG00000056133 kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000004586 ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSDARG00000042723 gfra2a / GDNF family receptor alpha 2a / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSDARG00000043962 fgf18b / fibroblast growth factor 18b / FGF18* / O89101* / O76093* / fibroblast growth factor 18*  / reaction / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000044015 gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSDARG00000055305 ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...  / complex
 ENSDARG00000028663 tek / TEK tyrosine kinase, endothelial / Q02763* / TEK receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / reaction / complex
 ENSDARG00000076294 klb / klotho beta / Q86Z14* / Q99N32* / Beta-klotho *  / complex / reaction
 ENSDARG00000079849 nrtn / neurturin / P97463* / Q99748*  / complex
 ENSDARG00000074582 gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*  / complex
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction / complex
 ENSDARG00000102778 fgf17 / Q6SJP8 / fibroblast growth factor 17 / O60258* / P63075*  / reaction / complex
 ENSDARG00000068653 rhoga / ras homolog family member Ga / RHOG* / P84095* / P84096* / ras homolog family member G*  / reaction / complex
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction / complex
 ENSDARG00000038010 rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction
 ENSDARG00000069105 fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction / complex
 ENSDARG00000086070 fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex / reaction
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / complex / reaction
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction / complex
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / complex / reaction
 ENSDARG00000004301 rhogb / ras homolog family member Gb / RHOG* / P84095* / P84096* / ras homolog family member G*  / reaction / complex
 ENSDARG00000098663 fgf19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / complex / reaction
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / reaction / complex
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / reaction / complex
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction / complex
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / reaction
 ENSDARG00000087704 gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex
 ENSDARG00000089983 si:ch73-109i22.2 / Q9NP31* / Q9QXK9* / SH2D2A* / SH2 domain containing 2A*  / complex / reaction
 ENSDARG00000094894 tyrobp / TYRO protein tyrosine kinase binding protein / O43914* / O54885*  / complex / reaction
 ENSDARG00000039959 gdnfa / glial cell derived neurotrophic factor a / GDNF* / P39905* / P48540* / glial cell derived neurotrophic factor* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), tra...  / complex
 ENSDARG00000102525 lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / complex / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction






 

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