ENSDARG00000075121


Danio rerio

Features
Gene ID: ENSDARG00000075121
  
Biological name :hbegfa
  
Synonyms : hbegfa / heparin-binding EGF-like growth factor a
  
Possible biological names infered from orthology : HBEGF / heparin binding EGF like growth factor / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186 / Q99075
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 7048930
Gene end: 7051940
  
Corresponding Affymetrix probe sets: Dr.16053.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000099541
NCBI entrez gene - 797938     See in Manteia.
RefSeq - NM_001111226
RefSeq Peptide - NP_001104696
swissprot - A9JRW9
ZFIN ID - ZDB-GENE-080204-119
Ensembl - ENSDARG00000075121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HBEGFENSGALG00000000949Gallus gallus
 HBEGFENSG00000113070Homo sapiens
 HbegfENSMUSG00000024486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hbegfb / heparin-binding EGF-like growth factor b / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...ENSDARG0000003124641
areg / amphiregulin / Mcub* / P15514* / P31955*ENSDARG0000007685319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0070654 sensory epithelium regeneration IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000152 retina retina cell proliferation decreased occurrence , abnormal
Show

 ZFA:0009280 Muller cell Muller cell proliferative , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / reaction / complex
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000062688 gpnmb / glycoprotein (transmembrane) nmb / Q14956* / Q99P91* / glycoprotein nmb* / Transmembrane glycoprotein NMB *  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction / complex
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000074670 matk / megakaryocyte-associated tyrosine kinase / P42679*  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction






 

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