ENSDARG00000034293


Danio rerio

Features
Gene ID: ENSDARG00000034293
  
Biological name :hif1ab
  
Synonyms : hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b
  
Possible biological names infered from orthology : HIF1A / Hypoxia-inducible factor 1-alpha / hypoxia inducible factor 1 alpha subunit / Q16665 / Q61221
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 20326611
Gene end: 20355577
  
Corresponding Affymetrix probe sets: Dr.9052.1.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000004329
NCBI entrez gene - 393202     See in Manteia.
RefSeq - NM_001310042
RefSeq Peptide - NP_001296971
swissprot - Q6EHI4
ZFIN ID - ZDB-GENE-040426-706
Ensembl - ENSDARG00000034293
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HIF1AENSGALG00000011870Gallus gallus
 HIF1AENSG00000100644Homo sapiens
 Hif1aENSMUSG00000021109Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...ENSDARG0000000618151
epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *ENSDARG0000005767146
epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *ENSDARG0000000869745
hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*ENSDARG0000010082635
hif1al2 / hypoxia-inducible factor 1, alpha subunit, like 2ENSDARG0000004455024
sim1a / single-minded family bHLH transcription factor 1a / SIM1* / Q61045* / P81133* / Single-minded homolog 1 * / single-minded family bHLH transcription factor 1*ENSDARG0000002331623
NPAS3 / neuronal PAS domain protein 3 / Q8IXF0*ENSDARG0000010982023
npas1 / neuronal PAS domain protein 1 / P97459* / Q99742* / Neuronal PAS domain-containing protein 1 *ENSDARG0000001587621
sim1b / single-minded family bHLH transcription factor 1b / SIM1* / Q61045* / P81133* / Single-minded homolog 1 * / single-minded family bHLH transcription factor 1*ENSDARG0000001378920
arnt2 / aryl-hydrocarbon receptor nuclear translocator 2 / Q61324* / Q9HBZ2*ENSDARG0000010369716
arnt / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*ENSDARG0000002185515
arntl1b / aryl hydrocarbon receptor nuclear translocator-like 1b / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...ENSDARG0000003573215
clocka / clock circadian regulator a / CLOCK* / O15516* / O08785* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSDARG0000001170315
arntl1a / aryl hydrocarbon receptor nuclear translocator-like 1a / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...ENSDARG0000000679115
arntl2 / aryl hydrocarbon receptor nuclear translocator-like 2 / Q2VPD4* / Q8WYA1* / Aryl hydrocarbon receptor nuclear translocator-like protein 2 *ENSDARG0000004138115
clockb / clock circadian regulator b / CLOCK* / O15516* / O08785* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSDARG0000000363114
npas2 / neuronal PAS domain protein 2 / Q99743*ENSDARG0000001653614
CABZ01064671.1ENSDARG0000003993512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001321  Hypoxia-inducible factor-1 alpha
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR014887  HIF-1 alpha, transactivation domain, C-terminal
 IPR021537  Hypoxia-inducible factor, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0045765 regulation of angiogenesis IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051402 neuron apoptotic process IGI
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:1905517 macrophage migration IGI
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Ub-specific processing proteases
PTK6 promotes HIF1A stabilization
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure amount , ameliorated
anatomical structure decreased amount , abnormal
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 ZFA:0000152 retina retina increased amount , abnormal
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 ZFA:0001114 head head increased amount , abnormal
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 ZFA:0001115 trunk trunk motor neuron increased amount , abnormal
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 ZFA:0001202 optic cup optic cup increased amount , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium malformed , abnormal
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 ZFA:0001338 intestine intestine goblet cell decreased amount , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
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 ZFA:0005323 ionocyte ionocyte amount , ameliorated
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 ZFA:0009052 motor neuron motor neuron axon guidance decreased process quality , ameliorated
motor neuron axon truncated , ameliorated
motor neuron axon guidance decreased process quality , abnormal
motor neuron axon truncated , abnormal
Show

 ZFA:0009094 goblet cell goblet cell cell maturation disrupted , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004632 egln1b / egl-9 family hypoxia-inducible factor 1b / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / reaction / complex
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex
 ENSDARG00000038996 egln1a / egl-9 family hypoxia-inducible factor 1a / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / reaction / complex
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / complex / reaction
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / reaction / complex
 ENSDARG00000038576 ube2d1b / ubiquitin-conjugating enzyme E2D 1b / UBE2D1* / P51668* / P61080* / ubiquitin conjugating enzyme E2 D1*  / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex
 ENSDARG00000013965 cul2 / cullin 2 / Q13617* / Q9D4H8*  / complex / reaction
 ENSDARG00000043484 ube2d2 / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) / P62838* / P62837* / Ube2d2a* / ubiquitin conjugating enzyme E2 D2* / ubiquitin-conjugating enzyme E2D 2A*  / reaction
 ENSDARG00000021855 arnt / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*  / complex / reaction
 ENSDARG00000031915 hif1an / P59723 / hypoxia inducible factor 1, alpha subunit inhibitor / Q8BLR9* / Q9NWT6* / Hypoxia-inducible factor 1-alpha inhibitor *  / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction
 ENSDARG00000062688 gpnmb / glycoprotein (transmembrane) nmb / Q14956* / Q99P91* / glycoprotein nmb* / Transmembrane glycoprotein NMB *  / reaction
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / reaction
 ENSDARG00000004132 usp19 / ubiquitin specific peptidase 19 / O94966* / Q3UJD6*  / complex / reaction
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction
 ENSDARG00000062562 egln2 / egl-9 family hypoxia-inducible factor 2 / Q96KS0* / Q91YE2* / AC008537.1* / Egl nine homolog 2 *  / reaction






 

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