ENSDARG00000031915


Danio rerio

Features
Gene ID: ENSDARG00000031915
  
Biological name :hif1an
  
Synonyms : hif1an / hypoxia inducible factor 1, alpha subunit inhibitor / P59723
  
Possible biological names infered from orthology : Hypoxia-inducible factor 1-alpha inhibitor / Q8BLR9 / Q9NWT6
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 29952633
Gene end: 29980215
  
Corresponding Affymetrix probe sets: Dr.13371.1.S1_at (Zebrafish Array)   NM_201496_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000042048
NCBI entrez gene - 373126     See in Manteia.
RefSeq - NM_201496
RefSeq Peptide - NP_958904
swissprot - P59723
ZFIN ID - ZDB-GENE-030826-19
Ensembl - ENSDARG00000031915
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HIF1ANENSGALG00000005698Gallus gallus
 HIF1ANENSG00000166135Homo sapiens
 Hif1anENSMUSG00000036450Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kdm8 / lysine (K)-specific demethylase 8 / Q8N371* / Q9CXT6* / lysine demethylase 8* / JmjC domain-containing protein 5 *ENSDARG0000010251224
Q6AXL5 / hspbap1 / hspb associated protein 1 / Q8BK58* / Q96EW2* / HSPB1 associated protein 1*ENSDARG0000003377120
tyw5 / tRNA-yW synthesizing protein 5 / A2RSX7* / A2RUC4*ENSDARG0000006967218


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR027445  Hypoxia-inducible factor 1-alpha inhibitor
 IPR027452  Hypoxia-inducible factor 1-alpha inhibitor, domain II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IGI
 biological_processGO:0036138 peptidyl-histidine hydroxylation ISS
 biological_processGO:0042264 peptidyl-aspartic acid hydroxylation ISS
 biological_processGO:0042265 peptidyl-asparagine hydroxylation ISS
 biological_processGO:0055114 oxidation-reduction process ISS
 biological_processGO:1901343 negative regulation of vasculature development IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0036139 peptidyl-histidine dioxygenase activity ISS
 molecular_functionGO:0036140 peptidyl-asparagine 3-dioxygenase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0102113 hypoxia-inducible factor-asparagine oxygenase activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001285 intersegmental vessel intersegmental vessel angiogenic sprout increased amount , abnormal
Show

 ZFA:0005604 angiogenic sprout angiogenic sprout mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031915 hif1an / P59723 / hypoxia inducible factor 1, alpha subunit inhibitor / Q8BLR9* / Q9NWT6* / Hypoxia-inducible factor 1-alpha inhibitor *  / complex
 ENSDARG00000057671 epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / reaction
 ENSDARG00000008697 epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / reaction
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction






 

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