ENSG00000166135


Homo sapiens

Features
Gene ID: ENSG00000166135
  
Biological name :HIF1AN
  
Synonyms : HIF1AN / hypoxia inducible factor 1 alpha subunit inhibitor / Q9NWT6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.31
Gene start: 100529072
Gene end: 100559998
  
Corresponding Affymetrix probe sets: 218525_s_at (Human Genome U133 Plus 2.0 Array)   226648_at (Human Genome U133 Plus 2.0 Array)   59999_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299163
Ensembl peptide - ENSP00000433360
Ensembl peptide - ENSP00000432791
NCBI entrez gene - 55662     See in Manteia.
OMIM - 606615
RefSeq - XM_011539940
RefSeq - XM_011539941
RefSeq - NM_017902
RefSeq Peptide - NP_060372
swissprot - Q9NWT6
swissprot - E9PNR8
swissprot - E9PL41
Ensembl - ENSG00000166135
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hif1anENSDARG00000031915Danio rerio
 HIF1ANENSGALG00000005698Gallus gallus
 Hif1anENSMUSG00000036450Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM8 / Q8N371 / lysine demethylase 8ENSG0000015566623
Q96EW2 / HSPBAP1 / HSPB1 associated protein 1ENSG0000016908722
TYW5 / A2RUC4 / tRNA-yW synthesizing protein 5ENSG0000016297118


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR027445  Hypoxia-inducible factor 1-alpha inhibitor
 IPR027452  Hypoxia-inducible factor 1-alpha inhibitor, domain II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0036138 peptidyl-histidine hydroxylation IDA
 biological_processGO:0042264 peptidyl-aspartic acid hydroxylation IDA
 biological_processGO:0042265 peptidyl-asparagine hydroxylation IMP
 biological_processGO:0045663 positive regulation of myoblast differentiation IDA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IDA
 biological_processGO:2001214 positive regulation of vasculogenesis NAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors EXP
 molecular_functionGO:0019826 oxygen sensor activity NAS
 molecular_functionGO:0031406 carboxylic acid binding IDA
 molecular_functionGO:0036139 peptidyl-histidine dioxygenase activity IDA
 molecular_functionGO:0036140 peptidyl-asparagine 3-dioxygenase activity IMP
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048037 cofactor binding IDA
 molecular_functionGO:0051059 NF-kappaB binding IPI
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0071532 ankyrin repeat binding IPI
 molecular_functionGO:0102113 hypoxia-inducible factor-asparagine oxygenase activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / reaction
 ENSG00000166135 HIF1AN / Q9NWT6 / hypoxia inducible factor 1 alpha subunit inhibitor  / complex






 

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