ENSG00000162971


Homo sapiens

Features
Gene ID: ENSG00000162971
  
Biological name :TYW5
  
Synonyms : A2RUC4 / tRNA-yW synthesizing protein 5 / TYW5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q33.1
Gene start: 199929975
Gene end: 199955736
  
Corresponding Affymetrix probe sets: 235181_at (Human Genome U133 Plus 2.0 Array)   235686_at (Human Genome U133 Plus 2.0 Array)   241825_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000346627
Ensembl peptide - ENSP00000420024
Ensembl peptide - ENSP00000398447
NCBI entrez gene - 129450     See in Manteia.
RefSeq - NM_001039693
RefSeq - XM_017003310
RefSeq Peptide - NP_001034782
swissprot - A8KAJ9
swissprot - A2RUC4
Ensembl - ENSG00000162971
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tyw5ENSDARG00000069672Danio rerio
 TYW5ENSGALG00000008145Gallus gallus
 Tyw5ENSMUSG00000048495Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96EW2 / HSPBAP1 / HSPB1 associated protein 1ENSG0000016908723
KDM8 / Q8N371 / lysine demethylase 8ENSG0000015566621
HIF1AN / Q9NWT6 / hypoxia inducible factor 1 alpha subunit inhibitorENSG0000016613520


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR029612  tRNA wybutosine-synthesizing protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006400 tRNA modification TAS
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0031591 wybutosine biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm TAS
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0102524 tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of wybutosine at G37 of tRNA(Phe)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162971 TYW5 / A2RUC4 / tRNA-yW synthesizing protein 5  / complex






 

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