ENSG00000155666


Homo sapiens

Features
Gene ID: ENSG00000155666
  
Biological name :KDM8
  
Synonyms : KDM8 / lysine demethylase 8 / Q8N371
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p12.1
Gene start: 27203495
Gene end: 27221768
  
Corresponding Affymetrix probe sets: 220070_at (Human Genome U133 Plus 2.0 Array)   241045_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456107
Ensembl peptide - ENSP00000455463
Ensembl peptide - ENSP00000456901
Ensembl peptide - ENSP00000286096
Ensembl peptide - ENSP00000398410
Ensembl peptide - ENSP00000454215
NCBI entrez gene - 79831     See in Manteia.
OMIM - 611917
RefSeq - XM_017023680
RefSeq - NM_001145348
RefSeq - NM_024773
RefSeq - XM_017023676
RefSeq - XM_017023677
RefSeq - XM_017023678
RefSeq - XM_017023679
RefSeq Peptide - NP_079049
RefSeq Peptide - NP_001138820
swissprot - H3BPT5
swissprot - Q8N371
swissprot - A0A0S2Z5T1
swissprot - H3BR76
swissprot - H3BM39
Ensembl - ENSG00000155666
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm8ENSDARG00000102512Danio rerio
 KDM8ENSGALG00000006301Gallus gallus
 Kdm8ENSMUSG00000030752Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HIF1AN / Q9NWT6 / hypoxia inducible factor 1 alpha subunit inhibitorENSG0000016613518
Q96EW2 / HSPBAP1 / HSPB1 associated protein 1ENSG0000016908716
TYW5 / A2RUC4 / tRNA-yW synthesizing protein 5ENSG0000016297115


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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