ENSMUSG00000030752


Mus musculus

Features
Gene ID: ENSMUSG00000030752
  
Biological name :Kdm8
  
Synonyms : JmjC domain-containing protein 5 / Kdm8 / Q9CXT6
  
Possible biological names infered from orthology : lysine demethylase 8 / Q8N371
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 125444676
Gene end: 125462269
  
Corresponding Affymetrix probe sets: 10557317 (MoGene1.0st)   1451384_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114890
Ensembl peptide - ENSMUSP00000033010
NCBI entrez gene - 77035     See in Manteia.
MGI - MGI:1924285
RefSeq - NM_029842
RefSeq - XM_017312384
RefSeq Peptide - NP_084118
swissprot - D3YUV8
swissprot - Q9CXT6
Ensembl - ENSMUSG00000030752
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm8ENSDARG00000102512Danio rerio
 KDM8ENSGALG00000006301Gallus gallus
 KDM8ENSG00000155666Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hif1an / Q8BLR9 / Hypoxia-inducible factor 1-alpha inhibitor / Q9NWT6* / hypoxia inducible factor 1 alpha subunit inhibitor*ENSMUSG0000003645021
Q8BK58 / Hspbap1 / HSPB1-associated protein 1 / Q96EW2*ENSMUSG0000002284917
Tyw5 / A2RSX7 / tRNA-yW synthesizing protein 5 / A2RUC4*ENSMUSG0000004849516


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) ISO


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

Allelic Composition: Kdm8Gt(AZ0518)Wtsi/Kdm8Gt(AZ0518)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm8tm1Tasu/Kdm8tm1Tasu
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

Allelic Composition: Kdm8tm1Tasu/Kdm8tm1Tasu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Kdm8Gt(AZ0518)Wtsi/Kdm8Gt(AZ0518)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Megf8b2b288Clo/Megf8b2b288Clo
Genetic Background: C57BL/6J-Megf8b2b288Clo

Allelic Composition: Kdm8Gt(AZ0518)Wtsi/Kdm8Gt(AZ0518)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kdm8tm1Tasu/Kdm8tm1Tasu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kdm8tm1Tasu/Kdm8tm1Tasu
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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