ENSMUSG00000036450


Mus musculus

Features
Gene ID: ENSMUSG00000036450
  
Biological name :Hif1an
  
Synonyms : Hif1an / Hypoxia-inducible factor 1-alpha inhibitor / Q8BLR9
  
Possible biological names infered from orthology : hypoxia inducible factor 1 alpha subunit inhibitor / Q9NWT6
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 44562850
Gene end: 44576274
  
Corresponding Affymetrix probe sets: 10463380 (MoGene1.0st)   1428576_at (Mouse Genome 430 2.0 Array)   1447817_at (Mouse Genome 430 2.0 Array)   1452845_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035326
NCBI entrez gene - 319594     See in Manteia.
MGI - MGI:2442345
RefSeq - NM_176958
RefSeq Peptide - NP_795932
swissprot - Q8BLR9
Ensembl - ENSMUSG00000036450
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hif1anENSDARG00000031915Danio rerio
 HIF1ANENSGALG00000005698Gallus gallus
 HIF1ANENSG00000166135Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm8 / Q9CXT6 / JmjC domain-containing protein 5 / Q8N371* / lysine demethylase 8*ENSMUSG0000003075224
Q8BK58 / Hspbap1 / HSPB1-associated protein 1 / Q96EW2*ENSMUSG0000002284922
Tyw5 / A2RSX7 / tRNA-yW synthesizing protein 5 / A2RUC4*ENSMUSG0000004849518


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR027445  Hypoxia-inducible factor 1-alpha inhibitor
 IPR027452  Hypoxia-inducible factor 1-alpha inhibitor, domain II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0036138 peptidyl-histidine hydroxylation IEA
 biological_processGO:0042264 peptidyl-aspartic acid hydroxylation IEA
 biological_processGO:0042265 peptidyl-asparagine hydroxylation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISO
 molecular_functionGO:0031406 carboxylic acid binding IEA
 molecular_functionGO:0036139 peptidyl-histidine dioxygenase activity IEA
 molecular_functionGO:0036140 peptidyl-asparagine 3-dioxygenase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048037 cofactor binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0071532 ankyrin repeat binding IEA
 molecular_functionGO:0102113 hypoxia-inducible factor-asparagine oxygenase activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hif1antm1.1Rsjo/Hif1antm1.1Rsjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001574 abnormal oxygen level "anomalous concentration of this gaseous element, essential for animal and plant life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hif1antm1.1Rsjo/Hif1antm1.1Rsjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Hif1antm1.1Rsjo/Hif1antm1.1Rsjo,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Hif1antm1.1Rsjo/Hif1antm1.1Rsjo,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003028 alkalosis "a pathological condition characterized by a decrease in the hydrogen ion concentration of arterial blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003032 hypocapnia "reduced concentration of CO2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Hif1antm1.1Rsjo/Hif1antm1.1Rsjo,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / reaction
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000036450 Hif1an / Q8BLR9 / Hypoxia-inducible factor 1-alpha inhibitor / Q9NWT6* / hypoxia inducible factor 1 alpha subunit inhibitor*  / complex






 

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