ENSMUSG00000021109


Mus musculus

Features
Gene ID: ENSMUSG00000021109
  
Biological name :Hif1a
  
Synonyms : Hif1a / Hypoxia-inducible factor 1-alpha / Q61221
  
Possible biological names infered from orthology : hypoxia inducible factor 1 alpha subunit / Q16665
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 73901375
Gene end: 73947530
  
Corresponding Affymetrix probe sets: 10396421 (MoGene1.0st)   1416035_at (Mouse Genome 430 2.0 Array)   1427418_a_at (Mouse Genome 430 2.0 Array)   1431981_at (Mouse Genome 430 2.0 Array)   1448183_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106091
Ensembl peptide - ENSMUSP00000021530
Ensembl peptide - ENSMUSP00000106088
NCBI entrez gene - 15251     See in Manteia.
MGI - MGI:106918
RefSeq - XM_017314961
RefSeq - NM_001313919
RefSeq - NM_001313920
RefSeq - NM_010431
RefSeq - XM_006515478
RefSeq Peptide - NP_001300848
RefSeq Peptide - NP_001300849
RefSeq Peptide - NP_034561
swissprot - A0A0R4J1F0
swissprot - Q61221
swissprot - A0A0R4J1E9
Ensembl - ENSMUSG00000021109
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hif1aaENSDARG00000006181Danio rerio
 hif1abENSDARG00000034293Danio rerio
 HIF1AENSGALG00000011870Gallus gallus
 HIF1AENSG00000100644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414046
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*ENSMUSG0000000432832
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*ENSMUSG0000002101022
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991321
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*ENSMUSG0000006271321
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*ENSMUSG0000000198818
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*ENSMUSG0000002923815
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552215
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*ENSMUSG0000001570914
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607714
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*ENSMUSG0000005511613
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001321  Hypoxia-inducible factor-1 alpha
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR014887  HIF-1 alpha, transactivation domain, C-terminal
 IPR021537  Hypoxia-inducible factor, alpha subunit
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0001922 B-1 B cell homeostasis IMP
 biological_processGO:0001944 vasculature development IGI
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002052 positive regulation of neuroblast proliferation IGI
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003208 cardiac ventricle morphogenesis IMP
 biological_processGO:0006089 lactate metabolic process IMP
 biological_processGO:0006110 regulation of glycolytic process IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0010573 vascular endothelial growth factor production IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0014850 response to muscle activity IMP
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0019896 axonal transport of mitochondrion IEA
 biological_processGO:0021502 neural fold elevation formation IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0030502 negative regulation of bone mineralization IMP
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0032364 oxygen homeostasis IEA
 biological_processGO:0032909 regulation of transforming growth factor beta2 production IEA
 biological_processGO:0032963 collagen metabolic process IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042541 hemoglobin biosynthetic process IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045926 negative regulation of growth IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046716 muscle cell cellular homeostasis IMP
 biological_processGO:0046886 positive regulation of hormone biosynthetic process IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048593 camera-type eye morphogenesis IGI
 biological_processGO:0050790 regulation of catalytic activity IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0051541 elastin metabolic process IMP
 biological_processGO:0060574 intestinal epithelial cell maturation IMP
 biological_processGO:0061030 epithelial cell differentiation involved in mammary gland alveolus development IMP
 biological_processGO:0061072 iris morphogenesis IGI
 biological_processGO:0061298 retina vasculature development in camera-type eye IMP
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 biological_processGO:0070243 regulation of thymocyte apoptotic process IGI
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IMP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IMP
 biological_processGO:0097411 hypoxia-inducible factor-1alpha signaling pathway IDA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IMP
 biological_processGO:1903715 regulation of aerobic respiration IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IGI
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0070888 E-box binding IMP


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Ub-specific processing proteases
PTK6 promotes HIF1A stabilization
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp8tm1Syon/Casp8tm1Syon
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Casp8tm1Syon/Casp8tm1Syon
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Casp8tm1Syon/Casp8tm1Syon
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0000440 domed skull 
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Epas1tm1Mcs/Epas1tm1Mcs,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0000801 abnormal temporal lobe morphology "malformation or absence of the lower lateral part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0000804 abnormal occipital lobe morphology "malformation or absence of the posterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Hif1atm1.1Mcs/Hif1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arnttm1Bra/Arnttm1Bra,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Arnttm1Bra/Arnttm1Bra,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Arnttm1Bra/Arnttm1Bra,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hif1atm1.1Mcs/Hif1atm1.1Mcs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm1.1Mcs/Hif1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002047 hepatic hemangioma "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Epas1tm1Mcs/Epas1tm1Mcs,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Meis1tm2Ngc/Meis1tm2Ngc,Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Meis1tm2Ngc/Meis1tm2Ngc,Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Hif1atm2Mcs/Hif1atm2Mcs
Genetic Background: Not Specified

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp8tm1Syon/Casp8tm1Syon
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002332 abnormal exercise endurance "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Epas1tm1Mcs/Epas1tm1Mcs,Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

Allelic Composition: Egln1tm1.1Fsl/Egln1+,Hif1atm3.1Rsjo/Hif1a+
Genetic Background: B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1.1Mcs/Hif1atm1.1Mcs
Genetic Background: involves: 129S6/SvEvTac

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Meis1tm2Ngc/Meis1tm2Ngc,Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Egln3tm1Pjr/Egln3tm1Pjr,Hif1atm1Pec/Hif1a+
Genetic Background: involves: 129S/SvEv * Swiss

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arnttm1Bra/Arnttm1Bra,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hif1atm1.1Mcs/Hif1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005535 abnormal body temperature "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Arnttm1Bra/Arnttm1Bra,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008125 abnormal dendritic cell number "anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0008556 abnormal tumor necrosis factor secretion "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008656 abnormal interleukin-1 beta secretion "anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008796 increased lens fiber apoptosis "increase in the number of lens fibers cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Meis1tm2Ngc/Meis1tm2Ngc,Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010642 absent third branchial arch "absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Meis1tm2Ngc/Meis1tm2Ngc,Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epas1tm1Mcs/Epas1tm1Mcs,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Epas1tm1Mcs/Epas1tm1Mcs,Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Hif1atm1Rsjo/Hif1atm3Rsjo,Tg(Col2a1-cre)1Rsjo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hif1atm1.1Mcs/Hif1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Hif1atm1.1Mcs/Hif1atm1.1Mcs
Genetic Background: involves: 129S6/SvEvTac

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129X1/SvJ * Swiss

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1

 MP:0011286 decreased circulating erythropoietin level "reduced blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Epas1tm1Mcs/Epas1tm1Mcs,Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1

 MP:0011287 increased erythropoietin level "greater fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0012265 increased hindbrain size "greater than average size of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0012492 branchial arch artery hypoplasia "underdevelopment or reduced size of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [MGI:anna]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0012493 absent branchial arch arteries "absence of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [MGI:anna]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction
 ENSMUSG00000015522 Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / reaction / complex
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / complex / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex / reaction
 ENSMUSG00000006676 Usp19 / Q3UJD6 / ubiquitin specific peptidase 19 / O94966*  / reaction / complex
 ENSMUSG00000035105 Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex / reaction
 ENSMUSG00000031987 Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex / reaction
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex
 ENSMUSG00000029816 Gpnmb / Q99P91 / Transmembrane glycoprotein NMB / Q14956* / glycoprotein nmb*  / reaction
 ENSMUSG00000036450 Hif1an / Q8BLR9 / Hypoxia-inducible factor 1-alpha inhibitor / Q9NWT6* / hypoxia inducible factor 1 alpha subunit inhibitor*  / reaction
 ENSMUSG00000036273 Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*  / reaction
 ENSMUSG00000058709 Egln2 / Q91YE2 / Egl nine homolog 2 / Q96KS0* / egl-9 family hypoxia inducible factor 2*  / reaction
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / reaction
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction






 

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