ENSMUSG00000025239


Mus musculus

Features
Gene ID: ENSMUSG00000025239
  
Biological name :Limd1
  
Synonyms : Limd1 / LIM domain-containing protein 1 / Q9QXD8
  
Possible biological names infered from orthology : LIM domains containing 1 / Q9UGP4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 123478706
Gene end: 123521552
  
Corresponding Affymetrix probe sets: 10590586 (MoGene1.0st)   1422730_at (Mouse Genome 430 2.0 Array)   1422731_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150888
Ensembl peptide - ENSMUSP00000026269
NCBI entrez gene - 29806     See in Manteia.
MGI - MGI:1352502
RefSeq - NM_013860
RefSeq Peptide - NP_038888
swissprot - A0A1L1SUR8
swissprot - Q9QXD8
Ensembl - ENSMUSG00000025239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01043952.1ENSDARG00000110954Danio rerio
 LIMD1ENSGALG00000035623Gallus gallus
 LIMD1ENSG00000144791Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wtip / Q7TQJ8 / WT1-interacting protein / A6NIX2*ENSMUSG0000003645929
Ajuba / Q91XC0 / LIM domain-containing protein ajuba / Q96IF1* / ajuba LIM protein*ENSMUSG0000002217828
Lpp / Q8BFW7 / Lipoma-preferred partner homolog / Q93052* / LIM domain containing preferred translocation partner in lipoma*ENSMUSG0000003330622
Zyx / zyxin / Q62523 / Q15942*ENSMUSG0000002986021
Trip6 / Q9Z1Y4 / thyroid hormone receptor interactor 6 / Q15654*ENSMUSG0000002334819
Fblim1 / Q71FD7 / Filamin-binding LIM protein 1 / Q8WUP2*ENSMUSG0000000621916
Ablim1 / Q8K4G5 / actin-binding LIM protein 1 / O14639*ENSMUSG0000002508511
Ablim3 / Q69ZX8 / actin binding LIM protein family, member 3 / O94929*ENSMUSG0000003273510
Ablim2 / Q8BL65 / actin-binding LIM protein 2 / Q6H8Q1* / actin binding LIM protein family member 2*ENSMUSG0000002909510
Dmtn / Q9WV69 / Dematin / Q08495* / dematin actin binding protein*ENSMUSG000000220994


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR028734  LIM domain-containing protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002076 osteoblast development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0033962 cytoplasmic mRNA processing body assembly IEA
 biological_processGO:0035195 gene silencing by miRNA IEA
 biological_processGO:0035329 hippo signaling IBA
 biological_processGO:0035331 negative regulation of hippo signaling IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IBA
 cellular_componentGO:0005912 adherens junction IBA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Dmrta1tm1.1Zark/Dmrta1+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmrta1tm1.1Zark/Dmrta1+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004983 abnormal osteoclast cell number "deviation from the average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmrta1tm1.1Zark/Dmrta1+
Genetic Background: involves: 129S1/Sv * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / complex / reaction
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / complex / reaction
 ENSMUSG00000035105 Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / complex
 ENSMUSG00000031987 Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*  / complex
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / complex
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / complex / reaction
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / reaction
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction






 

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