Manteia - Molecule gene

ENSMUSG00000033933

Mus musculus

Features

Gene ID:	ENSMUSG00000033933

Biological name :	Vhl

Synonyms :	P40338 / Vhl / von Hippel-Lindau tumor suppressor

Possible biological names infered from orthology :	P40337 / Q6RSH7 / VHLL / VHL like

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	E3
Gene start:	113623959
Gene end:	113631633

Corresponding Affymetrix probe sets:	10540790 (MoGene1.0st) 1421071_at (Mouse Genome 430 2.0 Array) 1434708_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000145326 Ensembl peptide - ENSMUSP00000039418 NCBI entrez gene - 22346 See in Manteia. MGI - MGI:103223 RefSeq - NM_009507 RefSeq Peptide - NP_033533 swissprot - A0A0N4SW09 swissprot - P40338 swissprot - Q3TTE7 Ensembl - ENSMUSG00000033933

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
vhl	ENSDARG00000070617	Danio rerio
	ENSGALG00000028009	Gallus gallus
VHL	ENSG00000134086	Homo sapiens
VHLL	ENSG00000189030	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR002714	von Hippel-Lindau tumour suppressor protein
IPR022772	von Hippel-Lindau disease tumour suppressor, beta/alpha domain
IPR024048	von Hippel-Lindau disease tumour suppressor, alpha domain
IPR024053	von Hippel-Lindau disease tumour suppressor, beta domain
IPR036208	VHL superfamily
IPR037139	von Hippel-Lindau disease tumour suppressor, alpha domain superfamily
IPR037140	von Hippel-Lindau disease tumour suppressor, beta domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0001525	angiogenesis	IMP
biological_process	GO:0001666	response to hypoxia	IEA
biological_process	GO:0003309	type B pancreatic cell differentiation	IMP
biological_process	GO:0003310	pancreatic A cell differentiation	IMP
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006582	melanin metabolic process	IMP
biological_process	GO:0006607	NLS-bearing protein import into nucleus	IMP
biological_process	GO:0008285	negative regulation of cell proliferation	ISO
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0010498	proteasomal protein catabolic process	IMP
biological_process	GO:0010629	negative regulation of gene expression	ISO
biological_process	GO:0015031	protein transport	IDA
biological_process	GO:0016567	protein ubiquitination	IBA
biological_process	GO:0030163	protein catabolic process	IMP
biological_process	GO:0030182	neuron differentiation	IEA
biological_process	GO:0030198	extracellular matrix organization	IMP
biological_process	GO:0042069	regulation of catecholamine metabolic process	IEA
biological_process	GO:0043534	blood vessel endothelial cell migration	IMP
biological_process	GO:0045471	response to ethanol	IEA
biological_process	GO:0045602	negative regulation of endothelial cell differentiation	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	ISO
biological_process	GO:0046426	negative regulation of JAK-STAT cascade	ISO
biological_process	GO:0048069	eye pigmentation	IMP
biological_process	GO:0048593	camera-type eye morphogenesis	IMP
biological_process	GO:0048877	homeostasis of number of retina cells	IMP
biological_process	GO:0050679	positive regulation of epithelial cell proliferation	IMP
biological_process	GO:0051291	protein heterooligomerization	IEA
biological_process	GO:0061072	iris morphogenesis	IMP
biological_process	GO:0061073	ciliary body morphogenesis	IMP
biological_process	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia	ISO
biological_process	GO:0070243	regulation of thymocyte apoptotic process	IGI
biological_process	GO:0070244	negative regulation of thymocyte apoptotic process	IMP
biological_process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	IMP
biological_process	GO:1903827	regulation of cellular protein localization	IMP
biological_process	GO:2001233	regulation of apoptotic signaling pathway	IGI
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005730	nucleolus	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005929	cilium	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030891	VCB complex	IEA
cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	ISO
molecular_function	GO:0019899	enzyme binding	ISO
molecular_function	GO:0061630	ubiquitin protein ligase activity	ISO

Pathways (from Reactome)

Pathway description

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

SUMOylation of ubiquitinylation proteins

Antigen processing: Ubiquitination & Proteasome degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0000260	abnormal angiogenesis	"aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Med31^l11Jus15/Med31^l11Jus15 Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hamp/Hamp2^{tm1.1(HAMP)Bjs}/Hamp/Hamp2^{tm1.1(HAMP)Bjs} Genetic Background: involves: 129 * NTac:NIHBS
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A)Kael}/Gt(ROSA)26Sor⁺,Tg(KRT14-cre)1Ipc/0 Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Zbtb7b^tm1.1Skok/Zbtb7b^tm1.1Skok Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0000521	abnormal kidney cortex	"anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Vhl^tm1.1Wkr/Vhl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0000530	abnormal kidney vasculature	"malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0000574	abnormal foot pad morphology	"anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 Allelic Composition: Vhl^tm1.1Lss/Vhl⁺ Genetic Background: involves: A/J Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0001138	abnormal cervical squamous epithelium	"malformation of the scaly epithelial layer of the cervix" [MGI:tc, J:54637]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6
MP:0001190	reddish skin	"skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A)Kael}/Gt(ROSA)26Sor⁺,Tg(KRT14-cre)1Ipc/0 Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A)Kael}/Gt(ROSA)26Sor⁺,Tg(KRT14-cre)1Ipc/0 Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A)Kael}/Gt(ROSA)26Sor⁺,Tg(KRT14-cre)1Ipc/0 Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0001613	abnormal vasodilation	"anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Uncx^tm1Pgr/Uncx^tm1Pgr Genetic Background: involves: NMRI Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA Allelic Composition: Vhl^tm1.1Wkr/Vhl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001636	irregular heartbeat	"uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0001656	focal hepatic necrosis	"a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0001712	abnormal placental development	"malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Sos1^tm1Dlb/Sos1^tm1Dlb Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001716	abnormal placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0001846	increased inflammatory response	"greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: a^t/A,As/As⁺ Genetic Background: Not Specified
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sos1^tm1Dlb/Sos1^tm1Dlb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6
MP:0002009	preneoplasia	"state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]	Show Allelic Composition: Ctsb^tm1Jde/Ctsb^tm1Jde,Ctsz^tm1Thre/Ctsz^tm1Thre,Tg(MMTV-PyVT)634Mul/0 Genetic Background: FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR
MP:0002047	hepatic hemangioma	"neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]	Show Allelic Composition: Uncx^tm1Pgr/Uncx^tm1Pgr Genetic Background: involves: NMRI Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Vhl^tm1.1Lss/Vhl⁺ Genetic Background: involves: BALB/c Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dhcr7^tm1Fdp/Dhcr7^tm2Fdp Genetic Background: involves: 129S4/SvJae Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA
MP:0002429	abnormal blood cell morphology/development	"anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0002608	increased hematocrit	"greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Uncx^tm1Pgr/Uncx^tm1Pgr Genetic Background: involves: NMRI Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Arnt^tm1Bra/Arnt^tm1Bra,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
MP:0002631	abnormal epididymis morphology	"malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnm1^tm2.1Pdc/Dnm1^tm2.1Pdc,Dnm2^tm1.1Pdc/Dnm2^tm1.1Pdc,Kdr^tm2.1Jrt/Kdr^tm2.1Jrt,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0002872	polycythemia	"an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0002884	abnormal branchial arches	"malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Parp4^tm1Leah/Parp4^tm1Leah,Tep1^tm1Leah/Tep1^tm1Leah Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
MP:0003070	increased vascular permeability	"greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A)Kael}/Gt(ROSA)26Sor⁺,Tg(KRT14-cre)1Ipc/0 Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0003135	increased erythrocyte precursors	"greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0003233	prolonged QT interval	"increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0003336	pancreatic cysts	"the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Blnk^tm1Kplm/Blnk^tm1Kplm Genetic Background: involves: 129P2/OlaHsd
MP:0003548	pulmonary hypertension	"sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0003574	abnormal oviduct morphology	"malformation of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR
MP:0003597	epididymal cystademona		Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0003893	increased hepatocyte proliferation	"anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Parp4^tm1Leah/Parp4^tm1Leah,Tep1^tm1Leah/Tep1^tm1Leah Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004042	decreased susceptibility to kidney reperfusion injury	"a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1.1Wkr/Vhl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Vhl^tm1Wml/Vhl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004809	increased hematopoietic stem cell number	"greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0004860	dilated kidney collecting duct	"stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0004938	dilated vasculature	"stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A)Kael}/Gt(ROSA)26Sor⁺,Tg(KRT14-cre)1Ipc/0 Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0004967	abnormal kidney epithelium morphology	"any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0004988	increased osteoblast cell number	"greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0005031	abnormal trophoblast	"malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sos1^tm1Dlb/Sos1^tm1Dlb Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Blnk^tm1Kplm/Blnk^tm1Kplm Genetic Background: involves: 129P2/OlaHsd
MP:0005220	abnormal exocrine pancreas morphology	"malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Blnk^tm1Kplm/Blnk^tm1Kplm Genetic Background: involves: 129P2/OlaHsd
MP:0005250	Sertoli cell hypoplasia	"decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6
MP:0005330	cardiomyopathy	"diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0005554	decreased circulating creatinine level	"less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0005564	increased hemoglobin content	"increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0005566	decreased blood urea nitrogen level	"low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0005601	increased angiogenesis	"enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0005650	abnormal limb bud morphology	"aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]	Show Allelic Composition: Parp4^tm1Leah/Parp4^tm1Leah,Tep1^tm1Leah/Tep1^tm1Leah Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006056	increased vascular endothelial cell number	"greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA Allelic Composition: Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Hprt^{tm1(Pck1-cre)Vhh}/Y,Vhl^tm1Jae/Vhl^tm1Jae Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Vhl^tm1Jae/Vhl^tm1Jae,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0008140	podocyte foot process effacement	"thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0008254	increased megakaryocyte cell number	"greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0008539	decreased susceptibility to induced colitis	"decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0008803	abnormal placental labyrinth vasculature morphology	"any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sos1^tm1Dlb/Sos1^tm1Dlb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0009043	pancreas adenoma	"a benign epithelial neoplasm located in the pancreas" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Blnk^tm1Kplm/Blnk^tm1Kplm Genetic Background: involves: 129P2/OlaHsd
MP:0009092	endometrium hyperplasia	"overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR
MP:0009308	adenocarcinoma	"malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Vhl^tm1.1Wkr/Vhl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0009583	increased keratinocyte proliferation	"increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A)Kael}/Gt(ROSA)26Sor⁺,Tg(KRT14-cre)1Ipc/0 Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
MP:0010383	increased adenoma incidence	"greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * ICR
MP:0010392	prolonged QRS complex duration	"increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Epas1^tm1Mcs/Epas1^tm1Mcs,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0010872	increased trabecular bone mass	"greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0010878	increased trabecular bone volume	"increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Epas1^tm1Mcs/Epas1^tm1Mcs,Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1
MP:0011066	abnormal renal tubule epithelial cell primary cilium morphology	"any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Blnk^tm1Kplm/Blnk^tm1Kplm Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Uncx^tm1Pgr/Uncx^tm1Pgr Genetic Background: involves: NMRI Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Vhl^tm1Bjg/Vhl^tm1Bjg Genetic Background: Not Specified
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Mcs/Vhl^tm1Mcs Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Ctsb^tm1Jde/Ctsb^tm1Jde,Ctsz^tm1Thre/Ctsz^tm1Thre,Tg(MMTV-PyVT)634Mul/0 Genetic Background: FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul
MP:0011285	increased circulating erythropoietin level	"greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1
MP:0011286	decreased circulating erythropoietin level	"reduced blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Epas1^tm1Mcs/Epas1^tm1Mcs,Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1 Allelic Composition: Epas1^tm1Mcs/Epas1^tm1Mcs,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * CD-1
MP:0011307	kidney medulla cysts	"abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0011336	abnormal kidney pelvis urothelium morphology	"any structural anomaly of the epithelial lining of the luminal space of the kidney pelvis" [MGI:csmith]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0011348	abnormal renal glomerulus basement membrane morphology	"any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011353	expanded mesangial matrix	"increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011372	decreased renal tubule apoptosis	"decrease in the number of renal tubule cells undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0011377	renal glomerulus fibrosis	"formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011402	renal cast	"any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011409	increased renal glomerulus basement membrane thickness	"increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011427	mesangial cell hyperplasia	"increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011440	increased kidney cell proliferation	"increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]	Show Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu,Vhl^tm1Jae/Vhl^tm1Jae,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR
MP:0011506	glomerular crescent	"formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011509	dilated glomerular capillary	"stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011523	thin placenta labyrinth	"decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0011629	decreased mitochondria number	"fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S4/SvJae * FVB/N
MP:0011753	decreased podocyte number	"reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [MGI:anna]	Show Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae,Tg(NPHS2-cre)295Lbh/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0013241	embryo tissue necrosis	"morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(CAG-cre/Esr1)1Lbe/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0020550	multinucleated giant male germ cells	"presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1.1Lss,Tg(ACTB-cre)1Tes/0 Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000019927	P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*	/ reaction
ENSMUSG00000024140	Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*	/ complex / reaction
ENSMUSG00000024231	Cul2 / Q9D4H8 / Cullin-2 / Q13617*	/ complex
ENSMUSG00000021109	Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*	/ reaction / complex
ENSMUSG00000022400	Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*	/ complex
ENSMUSG00000025239	Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*	/ complex
ENSMUSG00000004328	Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*	/ reaction / complex
ENSMUSG00000035105	Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*	/ complex
ENSMUSG00000026021	Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*	/ reaction / complex
ENSMUSG00000031987	Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*	/ complex
ENSMUSG00000015120	Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*	/ reaction
ENSMUSG00000055839	Elob / P62869 / Elongin-B / Q15370*	/ complex
ENSMUSG00000078578	P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*	/ reaction
ENSMUSG00000079658	Eloc / P83940 / Elongin-C / Q15369*	/ complex
ENSMUSG00000091896	P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr