ENSMUSG00000004328


Mus musculus

Features
Gene ID: ENSMUSG00000004328
  
Biological name :Hif3a
  
Synonyms : Hif3a / Hypoxia-inducible factor 3-alpha / Q0VBL6
  
Possible biological names infered from orthology : hypoxia inducible factor 3 alpha subunit / Q9Y2N7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 17031507
Gene end: 17062427
  
Corresponding Affymetrix probe sets: 10560329 (MoGene1.0st)   1421572_at (Mouse Genome 430 2.0 Array)   1425428_at (Mouse Genome 430 2.0 Array)   1425429_s_at (Mouse Genome 430 2.0 Array)   1446708_at (Mouse Genome 430 2.0 Array)   1447061_at (Mouse Genome 430 2.0 Array)   1459052_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117728
Ensembl peptide - ENSMUSP00000146258
Ensembl peptide - ENSMUSP00000048248
Ensembl peptide - ENSMUSP00000104132
NCBI entrez gene - 53417     See in Manteia.
MGI - MGI:1859778
RefSeq - NM_016868
RefSeq - XM_011250628
RefSeq - NM_001162950
RefSeq Peptide - NP_001156422
RefSeq Peptide - NP_058564
swissprot - A0A0U1RQ59
swissprot - Q0VBL6
swissprot - D3Z377
Ensembl - ENSMUSG00000004328
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hif1alENSDARG00000100826Danio rerio
 HIF3AENSG00000124440Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414040
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*ENSMUSG0000002110940
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*ENSMUSG0000002101025
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991324
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*ENSMUSG0000006271323
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*ENSMUSG0000000198822
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*ENSMUSG0000001570917
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*ENSMUSG0000002923817
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552217
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607717
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018715
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*ENSMUSG0000005511615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR021537  Hypoxia-inducible factor, alpha subunit
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006366 transcription by RNA polymerase II IPI
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IPI
 molecular_functionGO:0003700 DNA-binding transcription factor activity IPI
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0008727 enlarged right atrium "increased size of the right upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0010563 increased heart right ventricle size "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0010995 abnormal lung alveolus development "anomaly in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways" [GO:0048286]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0011144 thin lung-associated mesenchyme "decreased thickness of the mesenchymal cell layer in the developing lung" [MGI:anna]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction
 ENSMUSG00000015522 Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*  / complex / reaction
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / complex / reaction
 ENSMUSG00000031987 Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*  / complex / reaction
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / complex / reaction
 ENSMUSG00000035105 Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / reaction / complex
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / reaction / complex
 ENSMUSG00000058709 Egln2 / Q91YE2 / Egl nine homolog 2 / Q96KS0* / egl-9 family hypoxia inducible factor 2*  / reaction
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / reaction
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction






 

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