ENSMUSG00000055116


Mus musculus

Features
Gene ID: ENSMUSG00000055116
  
Biological name :Arntl
  
Synonyms : Arntl / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / Q9WTL8
  
Possible biological names infered from orthology : aryl hydrocarbon receptor nuclear translocator like / O00327
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F1
Gene start: 113207465
Gene end: 113314126
  
Corresponding Affymetrix probe sets: 10556463 (MoGene1.0st)   10556487 (MoGene1.0st)   1425099_a_at (Mouse Genome 430 2.0 Array)   1438862_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046235
Ensembl peptide - ENSMUSP00000147764
Ensembl peptide - ENSMUSP00000147823
Ensembl peptide - ENSMUSP00000147989
NCBI entrez gene - 11865     See in Manteia.
MGI - MGI:1096381
RefSeq - XM_017321950
RefSeq - NM_001243048
RefSeq - NM_001357070
RefSeq - NM_007489
RefSeq - XM_006507250
RefSeq - XM_006507251
RefSeq - XM_006507252
RefSeq - XM_006507253
RefSeq - XM_011241656
RefSeq - XM_017321949
RefSeq - XM_006507245
RefSeq - XM_006507246
RefSeq - XM_006507247
RefSeq - XM_006507248
RefSeq - XM_006507249
RefSeq Peptide - NP_001229977
RefSeq Peptide - NP_001343999
RefSeq Peptide - NP_031515
swissprot - Q3UHZ2
swissprot - Q9WTL8
swissprot - A0A1B0GS77
Ensembl - ENSMUSG00000055116
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arntl1aENSDARG00000006791Danio rerio
 arntl1bENSDARG00000035732Danio rerio
 ARNTLENSGALG00000005378Gallus gallus
 ARNTLENSG00000133794Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018742
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552232
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*ENSMUSG0000001570931
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*ENSMUSG0000002923821
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607720
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*ENSMUSG0000002110918
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*ENSMUSG0000000198817
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991317
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*ENSMUSG0000002101017
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414017
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*ENSMUSG0000006271316
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*ENSMUSG0000000432815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0042176 regulation of protein catabolic process IDA
 biological_processGO:0042634 regulation of hair cycle IEA
 biological_processGO:0042753 positive regulation of circadian rhythm IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0051775 response to redox state IEA
 biological_processGO:0060137 maternal process involved in parturition IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090403 oxidative stress-induced premature senescence IMP
 biological_processGO:1901985 positive regulation of protein acetylation IEA
 biological_processGO:2000074 regulation of type B pancreatic cell development IMP
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IMP
 biological_processGO:2000772 regulation of cellular senescence IMP
 biological_processGO:2001016 positive regulation of skeletal muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISA
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0000424 retarded hair growth "slow growth of the hair, appears at normal time" [J:5476]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ctgftm1Mga/Ctgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Arntltm1.1Ljm/Arntltm1.1Ljm,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctgftm1Mga/Ctgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Krastm4Tyj
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA * ICR

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0003189 fused joints 
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003198 tendon calcification "pathologic deposition of calcium salts in the tendons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003200 joint calcification "pathologic deposition of calcium salts in the joints" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Arntltm1Bra/Arntltm1Bra,Tg(Scg2-tTA)1Jt/0,Tg(tetO-Arntl)1Jt/0
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA * ICR

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004622 sacral vertebral fusion "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004685 intervertebral calcification "process in which the cartilaginous and gelatinous structure found between vertebrae becomes hardened due to deposits of calcium salts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005504 abnormal ligament morphology "structural anomaly of the flexible bands of fibrous tissue that connect the articular extremities of bones " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Arntltm1Weit/Arntltm1Weit
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005626 decreased plasma anion gap "less than the normal interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate; low anion gap is relatively rare but may occur from the presence of abnormal positively charged proteins, as in multiple myeloma" [RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0005660 abnormal circulating adrenaline level "aberrant concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0005664 decreased circulating noradrenaline level "less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0006432 abnormal costal cartilage morphology "any structural anomaly of the nonvascular, resilient, flexible connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the costal cartilage above" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0009436 fragmentation of sleep/wake states "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0010213 abnormal circulating fibrinogen level "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0010686 abnormal hair follicle matrix region morphology "any structural anomaly of the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" [PMID:19211055]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0011021 abnormal circadian regulation of heart rate "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0011022 abnormal circadian regulation of systemic arterial blood pressure "any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours" [GO:0003052]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0013373 increased sebum secretion "increased production and/or release of the lipid-rich substance that is produced by the sebaceous glands, acts to lubricate and waterproof the skin and hair of mammals, and provides antibacterial activity; sebum is released by disintegrating sebocytes that are continuously replaced from progenitors in the periphery of the sebaceous gland; its composition varies across species" [MGI:Anna]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0014167 ectopic bone "the appearance of an extra bone structure at an atypical location" [MGI:csmith]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0020408 altered susceptibility to induced thrombosis "any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: B6.129-Arntltm1Bra

Allelic Composition: Arntltm1.1Weit/Arntltm1.1Weit
Genetic Background: involves: 129S4/SvJae * BALB/cJ

Allelic Composition: Arntltm1Bra/Arntltm1Weit,Syt10tm1.1(icre)Geno/Syt10+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Arntltm1Bra/Arntltm1Bra,Syt10tm1.1(icre)Geno/Syt10tm1.1(icre)Geno
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Arntltm1Bra/Arntltm1Weit,Syt10tm1.1(icre)Geno/Syt10tm1.1(icre)Geno
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Arntltm1.1Ljm/Arntltm1.1Ljm,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra,Tg(Scg2-tTA)1Jt/0,Tg(tetO-Arntl)1Jt/0
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Arntltm1Weit/Arntltm1Weit,Syt10tm1.1(icre)Geno/Syt10+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Arntltm1Bra/Arntltm1Weit,Syt10tm1.1(icre)Geno/Syt10+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0020475 delayed circadian behavior phase "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Tcf21tm3.1(cre/Esr1*)Eno/Tcf21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Arntltm1Bra/Arntl+,Usp2tm1.1Bjc/Usp2+
Genetic Background: involves: 129 * C57BL/6

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
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Allelic Composition: Arntltm1.2Shbi/Arntltm1.2Shbi
Genetic Background: involves: C57BL/6J

 MP:0020478 abnormal circadian sleep/wake cycle "any anomaly in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm" [GO:0042745]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / complex / reaction
 ENSMUSG00000020038 Cry1 / P97784 / Cryptochrome-1 / Q16526* / cryptochrome circadian regulator 1*  / complex / reaction
 ENSMUSG00000020893 Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*  / complex / reaction
 ENSMUSG00000029238 Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*  / complex / reaction
 ENSMUSG00000068742 Cry2 / Q9R194 / Cryptochrome-2 / Q49AN0* / cryptochrome circadian regulator 2*  / complex / reaction
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / reaction / complex






 

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