ENSMUSG00000020893


Mus musculus

Features
Gene ID: ENSMUSG00000020893
  
Biological name :Per1
  
Synonyms : O35973 / Per1 / Period circadian protein homolog 1
  
Possible biological names infered from orthology : O15534 / period circadian regulator 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69095217
Gene end: 69109960
  
Corresponding Affymetrix probe sets: 10377439 (MoGene1.0st)   1449851_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021271
Ensembl peptide - ENSMUSP00000121713
Ensembl peptide - ENSMUSP00000132635
Ensembl peptide - ENSMUSP00000122164
Ensembl peptide - ENSMUSP00000098566
Ensembl peptide - ENSMUSP00000099665
NCBI entrez gene - 18626     See in Manteia.
MGI - MGI:1098283
RefSeq - XM_006532481
RefSeq - XM_006532480
RefSeq - NM_001159367
RefSeq - NM_011065
RefSeq Peptide - NP_035195
RefSeq Peptide - NP_001152839
swissprot - O35973
swissprot - Q8C4K7
swissprot - Q8CHR1
swissprot - E9Q8V5
swissprot - B0QZN6
Ensembl - ENSMUSG00000020893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 per1aENSDARG00000056885Danio rerio
 per1bENSDARG00000012499Danio rerio
 PER1ENSG00000179094Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Per2 / period circadian regulator 2 / O15055*ENSMUSG0000005586641
Per3 / O70361 / Period circadian protein homolog 3 / P56645* / period circadian regulator 3*ENSMUSG0000002895731


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR013655  PAS fold-3
 IPR022728  Period circadian-like, C-terminal
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002028 regulation of sodium ion transport IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0009416 response to light stimulus IEP
 biological_processGO:0010608 posttranscriptional regulation of gene expression IMP
 biological_processGO:0032922 circadian regulation of gene expression ISO
 biological_processGO:0042634 regulation of hair cycle ISO
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043967 histone H4 acetylation ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046329 negative regulation of JNK cascade ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051591 response to cAMP IDA
 biological_processGO:0070932 histone H3 deacetylation IMP
 biological_processGO:0097167 circadian regulation of translation IMP
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:1900744 regulation of p38MAPK cascade ISS
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0070888 E-box binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm1Eac/Cd22tm1Eac
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Per1tm1Drw/Per1tm1Drw,Per2tm1Drw/Per2tm1Drw
Genetic Background: involves: 129S4/SvJae

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Per1tm1Brd/Per1tm1Brd,Per2tm1Brd/Per2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Per1tm1Brd/Per1tm1Brd
Genetic Background: involves: 129 * 129S7/SvEvBrd

Allelic Composition: Per1tm1Brd/Per1tm1Brd,Per2tm1Brd/Per2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd22tm1Eac/Cd22tm1Eac
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Per1tm1Drw/Per1tm1Drw,Per2tm1Drw/Per2tm1Drw
Genetic Background: involves: 129S4/SvJae

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Per1tm1Brd/Per1tm1Brd
Genetic Background: involves: 129 * 129S7/SvEvBrd

Allelic Composition: Per1tm1Brd/Per1tm1Brd,Per2tm1Brd/Per2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008961 abnormal basal metabolism "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
Show

Allelic Composition: Per1tm1Drw/Per1tm1Drw,Per2tm1Drw/Per2tm1Drw
Genetic Background: involves: 129S4/SvJae

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020414 abnormal fibroblast physiology "any functional anomaly in the cellular physiological processes carried out by a fibroblast cell population" [mgi:anna]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Cd22tm1Eac/Cd22tm1Eac
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Per1tm1Saco/Per1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Per1tm1Saco/Per1tm1Saco
Genetic Background: B6.129S2-Per1tm1Saco

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
Show

Allelic Composition: Per1tm1Brd/Per1tm1Brd,Per2tm1Brd/Per2tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Per1tm1Drw/Per1tm1Drw
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Per1tm1Drw/Per1tm1Drw,Per3tm1Drw/Per3tm1Drw
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Per1tm1Drw/Per1tm1Drw,Per2tm1Drw/Per2tm1Drw
Genetic Background: involves: 129S4/SvJae

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Per1tm1Saco/Per1tm1Saco
Genetic Background: B6.129S2-Per1tm1Saco

Allelic Composition: Per1tm1Saco/Per1+
Genetic Background: involves: 129S2/SvPas

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
Show

Allelic Composition: Per1tm1Saco/Per1tm1Saco
Genetic Background: B6.129S2-Per1tm1Saco

 MP:0020478 abnormal circadian sleep/wake cycle "any anomaly in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm" [GO:0042745]
Show

Allelic Composition: Per1tm1Drw/Per1tm1Drw
Genetic Background: involves: 129S4/SvJae

 MP:0030438 increased osteoblast proliferation "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / complex / reaction
 ENSMUSG00000020038 Cry1 / P97784 / Cryptochrome-1 / Q16526* / cryptochrome circadian regulator 1*  / complex
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / complex / reaction
 ENSMUSG00000068742 Cry2 / Q9R194 / Cryptochrome-2 / Q49AN0* / cryptochrome circadian regulator 2*  / complex
 ENSMUSG00000020893 Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*  / complex
 ENSMUSG00000055116 Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*  / complex / reaction
 ENSMUSG00000029238 Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*  / complex / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex / reaction






 

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