Manteia - Molecule gene

ENSMUSG00000028957

Mus musculus

Features

Gene ID:	ENSMUSG00000028957

Biological name :	Per3

Synonyms :	O70361 / Per3 / Period circadian protein homolog 3

Possible biological names infered from orthology :	P56645 / period circadian regulator 3

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	E2
Gene start:	151003652
Gene end:	151044665

Corresponding Affymetrix probe sets:	10518781 (MoGene1.0st) 1421086_at (Mouse Genome 430 2.0 Array) 1421087_at (Mouse Genome 430 2.0 Array) 1441445_at (Mouse Genome 430 2.0 Array) 1442243_at (Mouse Genome 430 2.0 Array) 1458176_at (Mouse Genome 430 2.0 Array) 1460662_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000099493 Ensembl peptide - ENSMUSP00000118950 NCBI entrez gene - 18628 See in Manteia. MGI - MGI:1277134 RefSeq - XM_017320035 RefSeq - NM_001289877 RefSeq - NM_001289878 RefSeq - NM_011067 RefSeq - XM_011250203 RefSeq - XM_017320031 RefSeq - XM_017320032 RefSeq - XM_017320033 RefSeq - XM_017320034 RefSeq Peptide - NP_001276806 RefSeq Peptide - NP_001276807 RefSeq Peptide - NP_035197 swissprot - O70361 swissprot - E9PV88 Ensembl - ENSMUSG00000028957

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
per3	ENSDARG00000010519	Danio rerio
PER3	ENSGALG00000000573	Gallus gallus
PER3	ENSG00000049246	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*	ENSMUSG00000020893	36
Per2 / period circadian regulator 2 / O15055*	ENSMUSG00000055866	35

Protein motifs (from Interpro)

Interpro ID	Name
IPR000014	PAS domain
IPR013655	PAS fold-3
IPR015524	Period circadian protein 3
IPR022728	Period circadian-like, C-terminal
IPR035965	PAS domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007623	circadian rhythm	IDA
biological_process	GO:0032922	circadian regulation of gene expression	IEA
biological_process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	IEA
biological_process	GO:0048511	rhythmic process	IEA
biological_process	GO:0050821	protein stabilization	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	ISS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019900	kinase binding	IPI
molecular_function	GO:0031625	ubiquitin protein ligase binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001326	retinal degeneration	"pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Mfrp^rdx/Mfrp^rdx,Per3^tm1Drw/Per3^tm1Drw Genetic Background: involves: 129S4/SvJae
MP:0001501	abnormal sleep pattern	"deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smpd1^tm1Wst/Smpd1^tm1Wst Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002573	behavioral despair	"depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]	Show Allelic Composition: Arhgap28^{tm2b(KOMP)Wtsi}/Arhgap28^{tm2b(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0004994	abnormal brain wave pattern	"any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smpd1^tm1Wst/Smpd1^tm1Wst Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Mfrp^rdx/Mfrp^rdx,Per3^tm1Drw/Per3^tm1Drw Genetic Background: involves: 129S4/SvJae
MP:0020470	shortened circadian behavior period	"decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]	Show Allelic Composition: Smpd1^tm1Wst/Smpd1^tm1Wst Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0020472	arrhythmic circadian behavior persistence	"loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]	Show Allelic Composition: Per1^tm1Drw/Per1^tm1Drw,Per3^tm1Drw/Per3^tm1Drw Genetic Background: involves: 129S4/SvJae Allelic Composition: Per2^tm1Drw/Per2^tm1Drw,Per3^tm1Drw/Per3^tm1Drw Genetic Background: involves: 129/Sv * 129S4/SvJae

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr