ENSMUSG00000025217


Mus musculus

Features
Gene ID: ENSMUSG00000025217
  
Biological name :Btrc
  
Synonyms : Btrc / F-box/WD repeat-containing protein 1A / Q3ULA2
  
Possible biological names infered from orthology : beta-transducin repeat containing E3 ubiquitin protein ligase / Q9Y297
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 45363734
Gene end: 45530013
  
Corresponding Affymetrix probe sets: 10463486 (MoGene1.0st)   1417325_at (Mouse Genome 430 2.0 Array)   1425680_a_at (Mouse Genome 430 2.0 Array)   1443142_at (Mouse Genome 430 2.0 Array)   1446925_at (Mouse Genome 430 2.0 Array)   1457305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152926
Ensembl peptide - ENSMUSP00000107567
Ensembl peptide - ENSMUSP00000153119
Ensembl peptide - ENSMUSP00000153661
Ensembl peptide - ENSMUSP00000153562
Ensembl peptide - ENSMUSP00000153427
Ensembl peptide - ENSMUSP00000070728
NCBI entrez gene - 12234     See in Manteia.
MGI - MGI:1338871
RefSeq - XM_017318046
RefSeq - XM_006526612
RefSeq - XM_006526613
RefSeq - XM_006526614
RefSeq - XM_006526615
RefSeq - XM_011247119
RefSeq - XM_011247120
RefSeq - XM_011247121
RefSeq - XM_011247122
RefSeq - XM_011247123
RefSeq - XM_011247127
RefSeq - NM_001037758
RefSeq - NM_001286465
RefSeq - NM_001286466
RefSeq - NM_009771
RefSeq - XM_006526607
RefSeq - XM_006526608
RefSeq - XM_006526610
RefSeq Peptide - NP_001273394
RefSeq Peptide - NP_001273395
RefSeq Peptide - NP_033901
RefSeq Peptide - NP_001032847
swissprot - A0A286YCD6
swissprot - A0A286YE08
swissprot - Q3ULA2
swissprot - A0A286YDT6
swissprot - A0A286YDI3
swissprot - A0A286YCS1
Ensembl - ENSMUSG00000025217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BTRCENSGALG00000007820Gallus gallus
 BTRCENSG00000166167Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*ENSMUSG0000002027177
Fbxw7 / Q8VBV4 / F-box/WD repeat-containing protein 7 / Q969H0* / F-box and WD repeat domain containing 7*ENSMUSG0000002808625
Zfp106 / zinc finger protein 106 / Q9H2Y7* / ZNF106*ENSMUSG0000002728820
Traf7 / TNF receptor-associated factor 7 / Q6Q0C0*ENSMUSG0000005275219
Q5SUS0 / Fbxw10 / F-box/WD repeat-containing protein 10 / CDRT1* / O95170* / Q5XX13* / CMT1A duplicated region transcript 1* / F-box and WD repeat domain containing 10*ENSMUSG0000009017316
Fbxw2 / F-box and WD repeat domain containing 2 / Q9UKT8*ENSMUSG0000003594915
Wdr86 / WD repeat domain 86 / Q86TI4*ENSMUSG0000005523514


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0031648 protein destabilization ISS
 biological_processGO:0033598 mammary gland epithelial cell proliferation IMP
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0042753 positive regulation of circadian rhythm IMP
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045862 positive regulation of proteolysis ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0045309 protein phosphorylated amino acid binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction / complex
 ENSMUSG00000020893 Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*  / reaction / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / complex / reaction
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction / complex
 ENSMUSG00000024235 Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000022070 Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*  / complex / reaction
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / complex / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex
 ENSMUSG00000059866 Tnip2 / Q99JG7 / TNFAIP3 interacting protein 2 / Q8NFZ5*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / complex / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSMUSG00000002983 Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*  / reaction / complex
 ENSMUSG00000005268 Prlr / Q08501 / prolactin receptor / P16471*  / complex / reaction
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / reaction / complex
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / reaction / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000019773 Fbxo5 / Q7TSG3 / F-box only protein 5 / Q9UKT4* / F-box protein 5*  / complex / reaction
 ENSMUSG00000037373 Ctbp1 / O88712 / C-terminal-binding protein 1 / Q13363*  / complex
 ENSMUSG00000025225 Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*  / complex / reaction
 ENSMUSG00000020275 Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*  / complex / reaction






 

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