ENSMUSG00000020235


Mus musculus

Features
Gene ID: ENSMUSG00000020235
  
Biological name :Fzr1
  
Synonyms : Fizzy-related protein homolog / Fzr1 / Q9R1K5
  
Possible biological names infered from orthology : fizzy and cell division cycle 20 related 1 / Q9UM11
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 81366222
Gene end: 81378516
  
Corresponding Affymetrix probe sets: 10371159 (MoGene1.0st)   1419451_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114203
Ensembl peptide - ENSMUSP00000020457
Ensembl peptide - ENSMUSP00000112868
NCBI entrez gene - 56371     See in Manteia.
MGI - MGI:1926790
RefSeq - NM_019757
RefSeq Peptide - NP_062731
swissprot - Q9R1K5
swissprot - D3YTV2
swissprot - F8WJ80
swissprot - Q3U3D4
Ensembl - ENSMUSG00000020235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzr1aENSDARG00000015254Danio rerio
 FZR1ENSGALG00000002085Gallus gallus
 FZR1ENSG00000105325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*ENSMUSG0000000639836
Cdc20b / cell division cycle 20B / Q86Y33*ENSMUSG0000007892626


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0040020 regulation of meiotic nuclear division IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070306 lens fiber cell differentiation IMP
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IEA
 biological_processGO:0090344 negative regulation of cell aging IMP
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001711 abnormal placenta 
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001714 absent trophoblast cells "missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fzr1Gt(3003)Tgen/Fzr1Gt(3003)Tgen
Genetic Background: involves: C57BL/6 * CBA

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003708 binucleate "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzr1Gt(3003)Tgen/Fzr1Gt(3003)Tgen
Genetic Background: involves: C57BL/6 * CBA

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fzr1Gt(3003)Tgen/Fzr1Gt(3003)Tgen
Genetic Background: involves: C57BL/6 * CBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Fzr1Gt(3003)Tgen/Fzr1Gt(3003)Tgen
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex
 ENSMUSG00000019773 Fbxo5 / Q7TSG3 / F-box only protein 5 / Q9UKT4* / F-box protein 5*  / reaction / complex
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / reaction / complex
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / reaction / complex
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction / complex
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex / reaction






 

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