ENSMUSG00000006398


Mus musculus

Features
Gene ID: ENSMUSG00000006398
  
Biological name :Cdc20
  
Synonyms : Cdc20 / Cell division cycle / Q9JJ66
  
Possible biological names infered from orthology : cell division cycle 20 / Q12834
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.1
Gene start: 118432901
Gene end: 118437352
  
Corresponding Affymetrix probe sets: 10515744 (MoGene1.0st)   1416664_at (Mouse Genome 430 2.0 Array)   1439377_x_at (Mouse Genome 430 2.0 Array)   1439394_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006565
Ensembl peptide - ENSMUSP00000139345
NCBI entrez gene - 107995     See in Manteia.
MGI - MGI:1859866
RefSeq - NM_023223
RefSeq Peptide - NP_075712
swissprot - Q9JJ66
swissprot - V9GXW0
Ensembl - ENSMUSG00000006398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc20ENSDARG00000100741Danio rerio
 CDC20ENSGALG00000009971Gallus gallus
 CDC20ENSG00000117399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*ENSMUSG0000002023536
Cdc20b / cell division cycle 20B / Q86Y33*ENSMUSG0000007892630


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family
 IPR033187  Cell division cycle protein 20 homologue
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007064 mitotic sister chromatid cohesion IGI
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity IDA
 biological_processGO:0040020 regulation of meiotic nuclear division IGI
 biological_processGO:0050773 regulation of dendrite development IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090129 positive regulation of synapse maturation IDA
 biological_processGO:0090307 mitotic spindle assembly IMP
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Mitotic Prometaphase
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0000423 delayed hair regrowth "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.1Mama,Pttg1tm1.1Kna/Pttg1tm1.1Kna
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Cdc20Gt(XE368)Byg/Cdc20Gt(XE368)Byg,Pttg1tm1Pzg/Pttg1tm1Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

Allelic Composition: Cdc20tm1.1Pzg/Cdc20+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc20Gt(XE368)Byg/Cdc20tm1Jvd
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.1Mama,Pttg1tm1.1Kna/Pttg1tm1.1Kna
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc20Gt(XE368)Byg/Cdc20tm1Jvd
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc20tm1.1Pzg/Cdc20+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010537 tumor regression "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Cdc20Gt(XE368)Byg/Cdc20Gt(XE368)Byg,Pttg1tm1Pzg/Pttg1tm1Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc20tm1.2Mama/Cdc20tm1.2Mama
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Cdc20tm1.1Pzg/Cdc20+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction / complex
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / complex / reaction
 ENSMUSG00000019773 Fbxo5 / Q7TSG3 / F-box only protein 5 / Q9UKT4* / F-box protein 5*  / complex / reaction
 ENSMUSG00000020415 Pttg1 / Q9CQJ7 / Securin / PTTG2* / O95997* / Q9NZH5* / pituitary tumor-transforming 1* / pituitary tumor-transforming 2*  / complex / reaction
 ENSMUSG00000026622 Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*  / complex / reaction
 ENSMUSG00000029910 Mad2l1 / Q9Z1B5 / Mitotic spindle assembly checkpoint protein MAD2A / Q13257* / mitotic arrest deficient 2 like 1*  / reaction / complex
 ENSMUSG00000040084 Bub1b / Q9Z1S0 / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / reaction / complex
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000066979 Bub3 / Q9WVA3 / Mitotic checkpoint protein BUB3 / O43684* / BUB3, mitotic checkpoint protein*  / reaction / complex
 ENSMUSG00000020020 Usp44 / Q8C2S0 / ubiquitin specific peptidase 44 / Q9H0E7*  / complex






 

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