ENSG00000117399


Homo sapiens

Features
Gene ID: ENSG00000117399
  
Biological name :CDC20
  
Synonyms : CDC20 / cell division cycle 20 / Q12834
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.2
Gene start: 43358955
Gene end: 43363203
  
Corresponding Affymetrix probe sets: 202870_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361540
Ensembl peptide - ENSP00000308450
NCBI entrez gene - 991     See in Manteia.
OMIM - 603618
RefSeq - NM_001255
RefSeq Peptide - NP_001246
swissprot - Q12834
Ensembl - ENSG00000117399
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc20ENSDARG00000100741Danio rerio
 CDC20ENSGALG00000009971Gallus gallus
 Cdc20ENSMUSG00000006398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1ENSG0000010532536
CDC20B / Q86Y33 / cell division cycle 20BENSG0000016428733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family
 IPR033187  Cell division cycle protein 20 homologue
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007064 mitotic sister chromatid cohesion IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IDA
 biological_processGO:0031915 positive regulation of synaptic plasticity IEA
 biological_processGO:0040020 regulation of meiotic nuclear division IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0050773 regulation of dendrite development IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0090129 positive regulation of synapse maturation IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IDA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Mitotic Prometaphase
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / complex / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction / complex
 ENSG00000154473 BUB3 / O43684 / BUB3, mitotic checkpoint protein  / complex / reaction
 ENSG00000164611 PTTG1 / O95997 / pituitary tumor-transforming 1  / reaction / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction / complex
 ENSG00000136014 USP44 / Q9H0E7 / ubiquitin specific peptidase 44  / complex
 ENSG00000117650 NEK2 / P51955 / NIMA related kinase 2  / complex / reaction
 ENSG00000156970 BUB1B / O60566 / BUB1 mitotic checkpoint serine/threonine kinase B  / reaction / complex
 ENSG00000164109 MAD2L1 / Q13257 / mitotic arrest deficient 2 like 1  / reaction / complex
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr