ENSG00000134057


Homo sapiens

Features
Gene ID: ENSG00000134057
  
Biological name :CCNB1
  
Synonyms : CCNB1 / cyclin B1 / P14635
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.2
Gene start: 69167010
Gene end: 69178245
  
Corresponding Affymetrix probe sets: 214710_s_at (Human Genome U133 Plus 2.0 Array)   228729_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426092
Ensembl peptide - ENSP00000424588
Ensembl peptide - ENSP00000426230
Ensembl peptide - ENSP00000425103
Ensembl peptide - ENSP00000256442
Ensembl peptide - ENSP00000423387
NCBI entrez gene - 891     See in Manteia.
OMIM - 123836
RefSeq - NM_031966
RefSeq Peptide - NP_114172
swissprot - H0Y9U8
swissprot - E9PC90
swissprot - P14635
swissprot - H0YA62
swissprot - D6RHI0
Ensembl - ENSG00000134057
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnb1ENSDARG00000051923Danio rerio
 Ccnb1ENSMUSG00000041431Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNB2 / O95067 / cyclin B2ENSG0000015745650
CCNB3 / Q8WWL7 / cyclin B3ENSG0000014708228
CCNA2 / P20248 / cyclin A2ENSG0000014538627
CCNA1 / P78396 / cyclin A1ENSG0000013310127
CCNE1 / P24864 / cyclin E1ENSG0000010517320
CCNO / P22674 / cyclin OENSG0000015266919
CCNE2 / O96020 / cyclin E2ENSG0000017530519
CCND2 / P30279 / cyclin D2ENSG0000011897113
CCND3 / P30281 / cyclin D3ENSG0000011257613
CCND1 / P24385 / cyclin D1ENSG0000011009213


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IMP
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IDA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IEA
 biological_processGO:0033129 positive regulation of histone phosphorylation IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0046680 response to DDT IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0051987 positive regulation of attachment of spindle microtubules to kinetochore IMP
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060623 regulation of chromosome condensation IEA
 biological_processGO:0071283 cellular response to iron(III) ion IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint IMP
 biological_processGO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport IDA
 biological_processGO:2000775 histone H3-S10 phosphorylation involved in chromosome condensation IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0097125 cyclin B1-CDK1 complex IDA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS
 molecular_functionGO:0005113 patched binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035173 histone kinase activity IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0061575 cyclin-dependent protein serine/threonine kinase activator activity IDA


Pathways (from Reactome)
Pathway description
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Depolymerisation of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101224 CDC25B / P30305 / cell division cycle 25B  / reaction
 ENSG00000134480 CCNH / P51946 / cyclin H  / reaction
 ENSG00000127564 PKMYT1 / Q99640 / protein kinase, membrane associated tyrosine/threonine 1  / reaction
 ENSG00000020426 MNAT1 / P51948 / MNAT1, CDK activating kinase assembly factor  / reaction
 ENSG00000134058 CDK7 / P50613 / cyclin dependent kinase 7  / reaction
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / complex / reaction
 ENSG00000146670 CDCA5 / Q96FF9 / cell division cycle associated 5  / reaction
 ENSG00000160789 LMNA / P02545 / lamin A/C  / reaction
 ENSG00000121892 PDS5A / Q29RF7 / PDS5 cohesin associated factor A  / reaction
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / reaction
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / reaction
 ENSG00000062650 WAPL / Q7Z5K2 / WAPL cohesin release factor  / reaction
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / reaction
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / reaction
 ENSG00000083642 PDS5B / Q9NTI5 / PDS5 cohesin associated factor B  / reaction
 ENSG00000119638 NEK9 / Q8TD19 / NIMA related kinase 9  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000120539 MASTL / Q96GX5 / microtubule associated serine/threonine kinase like  / reaction
 ENSG00000172943 PHF8 / Q9UPP1 / PHD finger protein 8  / reaction
 ENSG00000137497 NUMA1 / Q14980 / nuclear mitotic apparatus protein 1  / reaction
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / reaction / complex
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / reaction
 ENSG00000134324 LPIN1 / Q14693 / lipin 1  / reaction
 ENSG00000166483 WEE1 / P30291 / WEE1 G2 checkpoint kinase  / reaction
 ENSG00000164045 CDC25A / P30304 / cell division cycle 25A  / reaction
 ENSG00000158402 CDC25C / P30307 / cell division cycle 25C  / reaction
 ENSG00000175793 SFN / P31947 / stratifin  / reaction / complex






 

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