ENSG00000145386


Homo sapiens

Features
Gene ID: ENSG00000145386
  
Biological name :CCNA2
  
Synonyms : CCNA2 / cyclin A2 / P20248
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q27
Gene start: 121816444
Gene end: 121823933
  
Corresponding Affymetrix probe sets: 203418_at (Human Genome U133 Plus 2.0 Array)   213226_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481380
Ensembl peptide - ENSP00000274026
NCBI entrez gene - 890     See in Manteia.
OMIM - 123835
RefSeq - NM_001237
RefSeq Peptide - NP_001228
swissprot - P20248
Ensembl - ENSG00000145386
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccna2ENSDARG00000011094Danio rerio
 CCNA2ENSGALG00000011881Gallus gallus
 Ccna2ENSMUSG00000027715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNA1 / P78396 / cyclin A1ENSG0000013310148
CCNB3 / Q8WWL7 / cyclin B3ENSG0000014708229
CCNB1 / P14635 / cyclin B1ENSG0000013405728
CCNB2 / O95067 / cyclin B2ENSG0000015745625
CCNO / P22674 / cyclin OENSG0000015266919
CCNE1 / P24864 / cyclin E1ENSG0000010517318
CCNE2 / O96020 / cyclin E2ENSG0000017530518
CCND3 / P30281 / cyclin D3ENSG0000011257615
CCND2 / P30279 / cyclin D2ENSG0000011897114
CCND1 / P24385 / cyclin D1ENSG0000011009213


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR032447  Cyclin-A, N-terminal
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007265 Ras protein signal transduction IEP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016572 histone phosphorylation IDA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0044843 cell cycle G1/S phase transition IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071314 cellular response to cocaine IEA
 biological_processGO:0071373 cellular response to luteinizing hormone stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA
 cellular_componentGO:0001939 female pronucleus IEA
 cellular_componentGO:0001940 male pronucleus IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0097124 cyclin A2-CDK2 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0097472 cyclin-dependent protein kinase activity IDA


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135913 USP37 / Q86T82 / ubiquitin specific peptidase 37  / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / complex
 ENSG00000087191 PSMC5 / P62195 / proteasome 26S subunit, ATPase 5  / complex
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / complex






 

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