ENSG00000087191


Homo sapiens

Features
Gene ID: ENSG00000087191
  
Biological name :PSMC5
  
Synonyms : P62195 / proteasome 26S subunit, ATPase 5 / PSMC5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q23.3
Gene start: 63827152
Gene end: 63832026
  
Corresponding Affymetrix probe sets: 209503_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464405
Ensembl peptide - ENSP00000464646
Ensembl peptide - ENSP00000464602
Ensembl peptide - ENSP00000310572
Ensembl peptide - ENSP00000364970
Ensembl peptide - ENSP00000462098
Ensembl peptide - ENSP00000462495
Ensembl peptide - ENSP00000463107
Ensembl peptide - ENSP00000463549
Ensembl peptide - ENSP00000463801
Ensembl peptide - ENSP00000463938
Ensembl peptide - ENSP00000464347
NCBI entrez gene - 5705     See in Manteia.
OMIM - 601681
RefSeq - NM_001199163
RefSeq - NM_002805
RefSeq Peptide - NP_001186092
RefSeq Peptide - NP_002796
swissprot - J3QRR3
swissprot - J3QRW1
swissprot - J3QSA9
swissprot - J3QSE0
swissprot - A0A140VJS3
swissprot - P62195
swissprot - J3KRP2
swissprot - J3KTQ9
swissprot - J3QLH6
swissprot - J3QQM1
Ensembl - ENSG00000087191
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmc5ENSDARG00000015315Danio rerio
 PSMC5ENSGALG00000000349Gallus gallus
 Psmc5ENSMUSG00000020708Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005937  26S proteasome regulatory subunit P45-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily
 IPR035261  26S proteasome regulatory subunit 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006521 regulation of cellular amino acid metabolic process TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043069 negative regulation of programmed cell death NAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IBA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0090261 positive regulation of inclusion body assembly IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway TAS
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005838 proteasome regulatory particle IEA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0022624 proteasome accessory complex ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031595 nuclear proteasome complex IBA
 cellular_componentGO:0031597 cytosolic proteasome complex IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity TAS
 molecular_functionGO:0017025 TBP-class protein binding IBA
 molecular_functionGO:0031531 thyrotropin-releasing hormone receptor binding IPI
 molecular_functionGO:0036402 proteasome-activating ATPase activity IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / complex
 ENSG00000145386 CCNA2 / P20248 / cyclin A2  / complex
 ENSG00000133101 CCNA1 / P78396 / cyclin A1  / complex
 ENSG00000135913 USP37 / Q86T82 / ubiquitin specific peptidase 37  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr