ENSG00000133101


Homo sapiens

Features
Gene ID: ENSG00000133101
  
Biological name :CCNA1
  
Synonyms : CCNA1 / cyclin A1 / P78396
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q13.3
Gene start: 36431520
Gene end: 36442882
  
Corresponding Affymetrix probe sets: 205899_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486482
Ensembl peptide - ENSP00000255465
Ensembl peptide - ENSP00000400666
Ensembl peptide - ENSP00000486017
NCBI entrez gene - 8900     See in Manteia.
OMIM - 604036
RefSeq - XM_011535296
RefSeq - NM_001111045
RefSeq - NM_001111046
RefSeq - NM_001111047
RefSeq - NM_003914
RefSeq - XM_011535294
RefSeq - XM_011535295
RefSeq Peptide - NP_001104517
RefSeq Peptide - NP_003905
RefSeq Peptide - NP_001104515
RefSeq Peptide - NP_001104516
swissprot - P78396
swissprot - A0A140VJG0
Ensembl - ENSG00000133101
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccna1ENSDARG00000043236Danio rerio
 CCNA1ENSGALG00000017052Gallus gallus
 Ccna1ENSMUSG00000027793Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNA2 / P20248 / cyclin A2ENSG0000014538644
CCNB1 / P14635 / cyclin B1ENSG0000013405725
CCNB3 / Q8WWL7 / cyclin B3ENSG0000014708225
CCNB2 / O95067 / cyclin B2ENSG0000015745624
CCNE1 / P24864 / cyclin E1ENSG0000010517317
CCNE2 / O96020 / cyclin E2ENSG0000017530516
CCNO / P22674 / cyclin OENSG0000015266916
CCND3 / P30281 / cyclin D3ENSG0000011257615
CCND2 / P30279 / cyclin D2ENSG0000011897113
CCND1 / P24385 / cyclin D1ENSG0000011009213


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007141 male meiosis I TAS
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0097123 cyclin A1-CDK2 complex IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Activation of E2F1 target genes at G1/S
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135913 USP37 / Q86T82 / ubiquitin specific peptidase 37  / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / complex
 ENSG00000087191 PSMC5 / P62195 / proteasome 26S subunit, ATPase 5  / complex
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / complex






 

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