ENSG00000135913


Homo sapiens

Features
Gene ID: ENSG00000135913
  
Biological name :USP37
  
Synonyms : Q86T82 / ubiquitin specific peptidase 37 / USP37
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q35
Gene start: 218450251
Gene end: 218568361
  
Corresponding Affymetrix probe sets: 226729_at (Human Genome U133 Plus 2.0 Array)   226730_s_at (Human Genome U133 Plus 2.0 Array)   232033_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258399
Ensembl peptide - ENSP00000345043
Ensembl peptide - ENSP00000393662
Ensembl peptide - ENSP00000396585
Ensembl peptide - ENSP00000400902
NCBI entrez gene - 57695     See in Manteia.
RefSeq - XM_017004577
RefSeq - NM_020935
RefSeq - XM_005246724
RefSeq - XM_011511538
RefSeq - XM_011511541
RefSeq - XM_005246720
RefSeq - XM_005246721
RefSeq - XM_005246722
RefSeq Peptide - NP_065986
swissprot - Q86T82
swissprot - Q86W68
Ensembl - ENSG00000135913
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp37ENSDARG00000040990Danio rerio
 USP37ENSGALG00000011427Gallus gallus
 Usp37ENSMUSG00000033364Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP29 / Q9HBJ7 / ubiquitin specific peptidase 29ENSG0000013186441
USP26 / Q9BXU7 / ubiquitin specific peptidase 26ENSG0000013458839


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR003903  Ubiquitin interacting motif
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR032069  Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0006275 regulation of DNA replication IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0035871 protein K11-linked deubiquitination IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145386 CCNA2 / P20248 / cyclin A2  / complex
 ENSG00000133101 CCNA1 / P78396 / cyclin A1  / complex
 ENSG00000087191 PSMC5 / P62195 / proteasome 26S subunit, ATPase 5  / complex
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / complex






 

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