ENSG00000175792


Homo sapiens

Features
Gene ID: ENSG00000175792
  
Biological name :RUVBL1
  
Synonyms : Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q21.3
Gene start: 128064778
Gene end: 128153914
  
Corresponding Affymetrix probe sets: 201614_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000318297
Ensembl peptide - ENSP00000417370
Ensembl peptide - ENSP00000420738
Ensembl peptide - ENSP00000463669
Ensembl peptide - ENSP00000417254
NCBI entrez gene - 8607     See in Manteia.
OMIM - 603449
RefSeq - XM_017007357
RefSeq - NM_001319084
RefSeq - NM_001319086
RefSeq - NM_003707
RefSeq - XM_005247841
RefSeq - XM_011513248
RefSeq - XM_011513249
RefSeq - XM_017007356
RefSeq Peptide - NP_001306013
RefSeq Peptide - NP_003698
RefSeq Peptide - NP_001306015
swissprot - J3QLR1
swissprot - E7ETR0
swissprot - Q9Y265
swissprot - H7C4G5
swissprot - H7C4I3
Ensembl - ENSG00000175792
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ruvbl1ENSDARG00000002591Danio rerio
 RUVBL1ENSGALG00000005931Gallus gallus
 P60122ENSMUSG00000030079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010339  TIP49, C-terminal
 IPR012340  Nucleic acid-binding, OB-fold
 IPR027238  RuvB-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000492 box C/D snoRNP assembly IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043967 histone H4 acetylation IDA
 biological_processGO:0043968 histone H2A acetylation IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body IMP
 cellular_componentGO:0000812 Swr1 complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071339 MLL1 complex IDA
 cellular_componentGO:0097255 R2TP complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001094 TFIID-class transcription factor binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0017025 TBP-class protein binding IDA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Telomere Extension By Telomerase
Formation of the beta-catenin:TCF transactivating complex
HATs acetylate histones
UCH proteinases
Ub-specific processing proteases
DNA Damage Recognition in GG-NER
Deposition of new CENPA-containing nucleosomes at the centromere


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction / complex
 ENSG00000087191 PSMC5 / P62195 / proteasome 26S subunit, ATPase 5  / complex
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / complex / reaction
 ENSG00000196367 TRRAP / Q9Y4A5 / transformation/transcription domain associated protein  / complex / reaction
 ENSG00000135913 USP37 / Q86T82 / ubiquitin specific peptidase 37  / complex
 ENSG00000133101 CCNA1 / P78396 / cyclin A1  / complex
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000145386 CCNA2 / P20248 / cyclin A2  / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex






 

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