ENSG00000168148


Homo sapiens

Features
Gene ID: ENSG00000168148
  
Biological name :HIST3H3
  
Synonyms : HIST3H3 / histone cluster 3 H3 / Q16695
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.13
Gene start: 228424845
Gene end: 228425325
  
Corresponding Affymetrix probe sets: 208572_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355657
NCBI entrez gene - 8290     See in Manteia.
OMIM - 602820
RefSeq - NM_003493
RefSeq Peptide - NP_003484
swissprot - Q16695
Ensembl - ENSG00000168148
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P68431 / HIST1H3G / histone cluster 1 H3 family member gENSG0000027398397
P68431 / HIST1H3C / histone cluster 1 H3 family member cENSG0000027827297
P68431 / HIST1H3B / histone cluster 1 H3 family member bENSG0000027426797
P68431 / HIST1H3I / histone cluster 1 H3 family member iENSG0000027537997
P68431 / HIST1H3J / histone cluster 1 H3 family member jENSG0000019715397
P68431 / HIST1H3F / histone cluster 1 H3 family member fENSG0000027777597
P68431 / HIST1H3E / histone cluster 1 H3 family member eENSG0000027475097
P68431 / HIST1H3D / histone cluster 1 H3 family member dENSG0000019740997
P68431 / HIST1H3A / histone cluster 1 H3 family member aENSG0000027571497
P68431 / HIST1H3H / histone cluster 1 H3 family member hENSG0000027882897
Q71DI3 / HIST2H3C / histone cluster 2 H3 family member cENSG0000020381196
Q71DI3 / HIST2H3D / histone cluster 2 H3 family member dENSG0000018359896
Q71DI3 / HIST2H3A / histone cluster 2 H3 family member aENSG0000020385296
HIST2H3PS2 / histone cluster 2 H3 pseudogene 2ENSG0000020381894
H3F3A / P84243 / H3 histone family member 3AENSG0000016304193
H3F3B / P84243 / H3 histone family member 3BENSG0000013247593
H3F3C / Q6NXT2 / H3 histone family member 3CENSG0000018837590
H3.Y / histone cluster 2, H3c pseudogeneENSG0000026946675
P04908 / HIST1H2AE / histone cluster 1 H2A family member eENSG0000027707519
P04908 / HIST1H2AB / histone cluster 1 H2A family member bENSG0000027846319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000164  Histone H3/CENP-A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006334 nucleosome assembly IMP
 biological_processGO:0016233 telomere capping TAS
 biological_processGO:0032460 negative regulation of protein oligomerization IMP
 biological_processGO:0051290 protein heterotetramerization IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000786 nucleosome IDA
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011485 PPP5C / P53041 / protein phosphatase 5 catalytic subunit  / reaction
 ENSG00000127663 KDM4B / O94953 / lysine demethylase 4B  / complex / reaction
 ENSG00000080345 RIF1 / Q5UIP0 / replication timing regulatory factor 1  / complex / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / complex / reaction
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction
 ENSG00000139351 SYCP3 / Q8IZU3 / synaptonemal complex protein 3  / complex
 ENSG00000166313 APBB1 / O00213 / amyloid beta precursor protein binding family B member 1  / complex / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000153147 O60264 / SMARCA5 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5  / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / reaction
 ENSG00000009954 BAZ1B / Q9UIG0 / bromodomain adjacent to zinc finger domain 1B  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction / complex
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / complex / reaction
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / complex / reaction
 ENSG00000163322 Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit  / reaction / complex
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000196074 SYCP2 / Q9BX26 / synaptonemal complex protein 2  / complex
 ENSG00000196367 TRRAP / Q9Y4A5 / transformation/transcription domain associated protein  / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000128513 POT1 / Q9NUX5 / protection of telomeres 1  / complex / reaction
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / reaction / complex
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / complex / reaction
 ENSG00000158161 EYA3 / Q99504 / EYA transcriptional coactivator and phosphatase 3  / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / complex / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / complex / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000157212 PAXIP1 / Q6ZW49 / PAX interacting protein 1  / complex / reaction
 ENSG00000066135 KDM4A / O75164 / lysine demethylase 4A  / reaction / complex
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction
 ENSG00000087206 UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1  / complex / reaction






 

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