ENSG00000132475


Homo sapiens

Features
Gene ID: ENSG00000132475
  
Biological name :H3F3B
  
Synonyms : H3F3B / H3 histone family member 3B / P84243
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 75776434
Gene end: 75785893
  
Corresponding Affymetrix probe sets: 209069_s_at (Human Genome U133 Plus 2.0 Array)   211997_x_at (Human Genome U133 Plus 2.0 Array)   211998_at (Human Genome U133 Plus 2.0 Array)   211999_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467165
Ensembl peptide - ENSP00000468714
Ensembl peptide - ENSP00000468484
Ensembl peptide - ENSP00000254810
Ensembl peptide - ENSP00000465403
Ensembl peptide - ENSP00000465813
Ensembl peptide - ENSP00000466020
Ensembl peptide - ENSP00000466663
NCBI entrez gene - 3021     See in Manteia.
OMIM - 601058
RefSeq - NM_005324
RefSeq Peptide - NP_005315
swissprot - K7EP01
swissprot - K7ES00
swissprot - B2R4P9
swissprot - P84243
swissprot - K7EK07
swissprot - K7EMV3
Ensembl - ENSG00000132475
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PI20ENSDARG00000068436Danio rerio
 H3F3CENSGALG00000020078Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H3F3A / P84243 / H3 histone family member 3AENSG00000163041100
Q71DI3 / HIST2H3A / histone cluster 2 H3 family member aENSG0000020385297
Q71DI3 / HIST2H3C / histone cluster 2 H3 family member cENSG0000020381197
Q71DI3 / HIST2H3D / histone cluster 2 H3 family member dENSG0000018359897
P68431 / HIST1H3I / histone cluster 1 H3 family member iENSG0000027537996
P68431 / HIST1H3H / histone cluster 1 H3 family member hENSG0000027882896
P68431 / HIST1H3D / histone cluster 1 H3 family member dENSG0000019740996
P68431 / HIST1H3B / histone cluster 1 H3 family member bENSG0000027426796
P68431 / HIST1H3A / histone cluster 1 H3 family member aENSG0000027571496
P68431 / HIST1H3C / histone cluster 1 H3 family member cENSG0000027827296
P68431 / HIST1H3G / histone cluster 1 H3 family member gENSG0000027398396
H3F3C / Q6NXT2 / H3 histone family member 3CENSG0000018837596
P68431 / HIST1H3E / histone cluster 1 H3 family member eENSG0000027475096
P68431 / HIST1H3J / histone cluster 1 H3 family member jENSG0000019715396
P68431 / HIST1H3F / histone cluster 1 H3 family member fENSG0000027777596
HIST2H3PS2 / histone cluster 2 H3 pseudogene 2ENSG0000020381894
Q16695 / HIST3H3 / histone cluster 3 H3ENSG0000016814893
H3.Y / histone cluster 2, H3c pseudogeneENSG0000026946681
P04908 / HIST1H2AE / histone cluster 1 H2A family member eENSG0000027707520
P04908 / HIST1H2AB / histone cluster 1 H2A family member bENSG0000027846320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000164  Histone H3/CENP-A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006334 nucleosome assembly IMP
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IDA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0032200 telomere organization TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000094916 CBX5 / P45973 / chromobox 5  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / reaction / complex
 ENSG00000116833 NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2  / complex
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction
 ENSG00000129514 FOXA1 / P55317 / forkhead box A1  / complex / reaction
 ENSG00000123143 PKN1 / Q16512 / protein kinase N1  / complex / reaction
 ENSG00000136997 MYC / P01106 / MYC proto-oncogene, bHLH transcription factor  / complex
 ENSG00000132703 APCS / P02743 / amyloid P component, serum  / complex / reaction
 ENSG00000132510 KDM6B / O15054 / lysine demethylase 6B  / reaction
 ENSG00000004487 KDM1A / O60341 / lysine demethylase 1A  / complex / reaction
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000088305 DNMT3B / Q9UBC3 / DNA methyltransferase 3 beta  / reaction / complex
 ENSG00000169375 SIN3A / Q96ST3 / SIN3 transcription regulator family member A  / reaction / complex
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / complex / reaction
 ENSG00000142182 DNMT3L / Q9UJW3 / DNA methyltransferase 3 like  / reaction / complex
 ENSG00000100811 YY1 / P25490 / YY1 transcription factor  / complex
 ENSG00000134046 MBD2 / Q9UBB5 / methyl-CpG binding domain protein 2  / reaction / complex
 ENSG00000276043 UHRF1 / Q96T88 / ubiquitin like with PHD and ring finger domains 1  / complex / reaction
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / reaction / complex
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / complex / reaction
 ENSG00000198890 PRMT6 / Q96LA8 / protein arginine methyltransferase 6  / complex / reaction
 ENSG00000180573 Q93077 / HIST1H2AC / histone cluster 1 H2A family member c  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / complex / reaction
 ENSG00000119772 DNMT3A / Q9Y6K1 / DNA methyltransferase 3 alpha  / complex / reaction
 ENSG00000127663 KDM4B / O94953 / lysine demethylase 4B  / complex / reaction
 ENSG00000118058 KMT2A / Q03164 / lysine methyltransferase 2A  / complex / reaction
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / complex / reaction
 ENSG00000130816 DNMT1 / P26358 / DNA methyltransferase 1  / complex / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / complex / reaction
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex / reaction
 ENSG00000077463 SIRT6 / Q8N6T7 / sirtuin 6  / reaction / complex
 ENSG00000101945 O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1  / complex / reaction
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / complex / reaction
 ENSG00000132275 RRP8 / O43159 / ribosomal RNA processing 8  / complex / reaction
 ENSG00000092847 AGO1 / Q9UL18 / argonaute 1, RISC catalytic component  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000171940 O75362 / ZNF217 / zinc finger protein 217  / complex
 ENSG00000164256 PRDM9 / Q9NQV7 / PR/SET domain 9  / reaction
 ENSG00000171988 JMJD1C / Q15652 / jumonji domain containing 1C  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction
 ENSG00000114738 Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3  / reaction
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / reaction / complex
 ENSG00000124151 NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3  / complex
 ENSG00000169083 AR / P10275 / androgen receptor  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction
 ENSG00000107077 KDM4C / Q9H3R0 / lysine demethylase 4C  / reaction / complex






 

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