ENSG00000123908


Homo sapiens

Features
Gene ID: ENSG00000123908
  
Biological name :AGO2
  
Synonyms : AGO2 / argonaute 2, RISC catalytic component / Q9UKV8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 140520156
Gene end: 140635619
  
Corresponding Affymetrix probe sets: 1561042_at (Human Genome U133 Plus 2.0 Array)   213310_at (Human Genome U133 Plus 2.0 Array)   225569_at (Human Genome U133 Plus 2.0 Array)   225827_at (Human Genome U133 Plus 2.0 Array)   243304_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430176
Ensembl peptide - ENSP00000431056
Ensembl peptide - ENSP00000220592
Ensembl peptide - ENSP00000430164
NCBI entrez gene - 27161     See in Manteia.
OMIM - 606229
RefSeq - XM_017013317
RefSeq - NM_001164623
RefSeq - NM_012154
RefSeq - XM_011516965
RefSeq - XM_011516966
RefSeq - XM_011516968
RefSeq Peptide - NP_001158095
RefSeq Peptide - NP_036286
swissprot - E5RJY2
swissprot - Q9UKV8
swissprot - E5RGG9
Ensembl - ENSG00000123908
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago2ENSDARG00000061268Danio rerio
 AGO2ENSGALG00000040957Gallus gallus
 Ago2ENSMUSG00000036698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGO1 / Q9UL18 / argonaute 1, RISC catalytic componentENSG0000009284782
AGO3 / Q9H9G7 / argonaute 3, RISC catalytic componentENSG0000012607080
AGO4 / Q9HCK5 / argonaute 4, RISC catalytic componentENSG0000013469878
PIWIL2 / Q8TC59 / piwi like RNA-mediated gene silencing 2ENSG0000019718122
PIWIL1 / Q96J94 / piwi like RNA-mediated gene silencing 1ENSG0000012520721
PIWIL3 / Q7Z3Z3 / piwi like RNA-mediated gene silencing 3ENSG0000018457120
PIWIL4 / Q7Z3Z4 / piwi like RNA-mediated gene silencing 4ENSG0000013462720


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR028602  Protein argonaute-2
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006412 translation NAS
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010501 RNA secondary structure unwinding IMP
 biological_processGO:0010586 miRNA metabolic process TAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030422 production of siRNA involved in RNA interference TAS
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0031054 pre-miRNA processing IDA
 biological_processGO:0035087 siRNA loading onto RISC involved in RNA interference IDA
 biological_processGO:0035194 posttranscriptional gene silencing by RNA TAS
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IDA
 biological_processGO:0035278 miRNA mediated inhibition of translation IMP
 biological_processGO:0035279 mRNA cleavage involved in gene silencing by miRNA IMP
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0045947 negative regulation of translational initiation IDA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0090625 mRNA cleavage involved in gene silencing by siRNA IMP
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
 biological_processGO:1901165 positive regulation of trophoblast cell migration IMP
 biological_processGO:1905618 positive regulation of miRNA mediated inhibition of translation IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016442 RISC complex IC
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IDA
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0070578 RISC-loading complex IDA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0001047 core promoter binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity NAS
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035197 siRNA binding IDA
 molecular_functionGO:0035198 miRNA binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA IDA
 molecular_functionGO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA IMP
 molecular_functionGO:0098808 mRNA cap binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000155363 MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicase  / complex
 ENSG00000139546 Q15633 / TARBP2 / TARBP2, RISC loading complex RNA binding subunit  / complex
 ENSG00000180228 PRKRA / O75569 / protein activator of interferon induced protein kinase EIF2AK2  / complex
 ENSG00000090905 Q8NDV7 / TNRC6A / trinucleotide repeat containing 6A  / complex / reaction
 ENSG00000078687 Q9HCJ0 / TNRC6C / trinucleotide repeat containing 6C  / complex / reaction
 ENSG00000100697 DICER1 / Q9UPY3 / dicer 1, ribonuclease III  / complex
 ENSG00000100354 Q9UPQ9 / TNRC6B / trinucleotide repeat containing 6B  / complex / reaction
 ENSG00000133704 IPO8 / O15397 / importin 8  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000116918 TSNAX / Q99598 / translin associated factor X  / reaction
 ENSG00000132341 RAN / P62826 / RAN, member RAS oncogene family  / reaction
 ENSG00000211460 TSN / Q15631 / translin  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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