ENSG00000100354


Homo sapiens

Features
Gene ID: ENSG00000100354
  
Biological name :TNRC6B
  
Synonyms : Q9UPQ9 / TNRC6B / trinucleotide repeat containing 6B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 40044817
Gene end: 40335808
  
Corresponding Affymetrix probe sets: 1558142_at (Human Genome U133 Plus 2.0 Array)   213254_at (Human Genome U133 Plus 2.0 Array)   228998_at (Human Genome U133 Plus 2.0 Array)   229036_at (Human Genome U133 Plus 2.0 Array)   230779_at (Human Genome U133 Plus 2.0 Array)   238468_at (Human Genome U133 Plus 2.0 Array)   240044_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384795
Ensembl peptide - ENSP00000409429
Ensembl peptide - ENSP00000401946
Ensembl peptide - ENSP00000397491
Ensembl peptide - ENSP00000306759
Ensembl peptide - ENSP00000338371
NCBI entrez gene - 23112     See in Manteia.
OMIM - 610740
RefSeq - NM_001024843
RefSeq - NM_001162501
RefSeq - NM_015088
RefSeq Peptide - NP_001155973
RefSeq Peptide - NP_055903
RefSeq Peptide - NP_001020014
swissprot - Q9UPQ9
swissprot - A0A024R1N5
swissprot - H0Y720
swissprot - B0QYM5
Ensembl - ENSG00000100354
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-217f16.6ENSDARG00000076389Danio rerio
 si:dkey-46g23.1ENSDARG00000079723Danio rerio
 tnrc6bENSDARG00000074161Danio rerio
 ENSGALG00000012050Gallus gallus
 Q8BKI2ENSMUSG00000047888Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8NDV7 / TNRC6A / trinucleotide repeat containing 6AENSG0000009090539
Q9HCJ0 / TNRC6C / trinucleotide repeat containing 6CENSG0000007868734


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR019486  Argonaute hook domain
 IPR032226  TNRC6, PABC binding domain
 IPR033500  Trinucleotide repeat-containing gene 6B protein
 IPR034925  TNRC6B, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0035194 posttranscriptional gene silencing by RNA TAS
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
Post-transcriptional silencing by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / complex / reaction
 ENSG00000126070 AGO3 / Q9H9G7 / argonaute 3, RISC catalytic component  / complex
 ENSG00000092847 AGO1 / Q9UL18 / argonaute 1, RISC catalytic component  / complex
 ENSG00000155363 MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicase  / complex
 ENSG00000134698 AGO4 / Q9HCK5 / argonaute 4, RISC catalytic component  / complex






 

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