ENSMUSG00000047888


Mus musculus

Features
Gene ID: ENSMUSG00000047888
  
Biological name :Tnrc6b
  
Synonyms : Q8BKI2 / Tnrc6b / trinucleotide repeat containing 6b
  
Possible biological names infered from orthology : Q9UPQ9
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 80711313
Gene end: 80941085
  
Corresponding Affymetrix probe sets: 10425430 (MoGene1.0st)   1426545_at (Mouse Genome 430 2.0 Array)   1436982_at (Mouse Genome 430 2.0 Array)   1460024_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064336
Ensembl peptide - ENSMUSP00000153748
Ensembl peptide - ENSMUSP00000154573
NCBI entrez gene - 213988     See in Manteia.
MGI - MGI:2443730
RefSeq - NM_144812
RefSeq - NM_177124
RefSeq Peptide - NP_659061
RefSeq Peptide - NP_796098
swissprot - Q8BKI2
Ensembl - ENSMUSG00000047888
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-217f16.6ENSDARG00000076389Danio rerio
 si:dkey-46g23.1ENSDARG00000079723Danio rerio
 tnrc6bENSDARG00000074161Danio rerio
 ENSGALG00000012050Gallus gallus
 Q9UPQ9ENSG00000100354Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnrc6a / trinucleotide repeat containing 6a / Q8NDV7*ENSMUSG0000005270738
Tnrc6c / trinucleotide repeat containing 6C / Q9HCJ0*ENSMUSG0000002557137


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR019486  Argonaute hook domain
 IPR032226  TNRC6, PABC binding domain
 IPR033500  Trinucleotide repeat-containing gene 6B protein
 IPR034925  TNRC6B, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0031047 gene silencing by RNA ISO
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
Post-transcriptional silencing by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036698 Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*  / complex / reaction
 ENSMUSG00000028842 Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*  / complex
 ENSMUSG00000041530 Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*  / complex
 ENSMUSG00000002227 Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*  / complex
 ENSMUSG00000042500 Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*  / complex






 

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