ENSMUSG00000041530


Mus musculus

Features
Gene ID: ENSMUSG00000041530
  
Biological name :Ago1
  
Synonyms : Ago1 / Protein argonaute-1 / Q8CJG1
  
Possible biological names infered from orthology : argonaute 1, RISC catalytic component / Q9UL18
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 126435012
Gene end: 126468583
  
Corresponding Affymetrix probe sets: 10516371 (MoGene1.0st)   1434331_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095498
Ensembl peptide - ENSMUSP00000134871
Ensembl peptide - ENSMUSP00000135662
NCBI entrez gene - 236511     See in Manteia.
MGI - MGI:2446630
RefSeq - XM_011240521
RefSeq - NM_001317173
RefSeq - NM_001317174
RefSeq - NM_153403
RefSeq - XM_011240520
RefSeq Peptide - NP_001304102
RefSeq Peptide - NP_001304103
RefSeq Peptide - NP_700452
swissprot - H3BL59
swissprot - Q8CJG1
swissprot - H3BJ70
Ensembl - ENSMUSG00000041530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago1ENSDARG00000092644Danio rerio
 AGO1ENSGALG00000002249Gallus gallus
 AGO1ENSG00000092847Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*ENSMUSG0000002884285
Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSMUSG0000004250083
Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*ENSMUSG0000003669882
Piwil2 / Q8CDG1 / Piwi-like protein 2 / Q8TC59* / piwi like RNA-mediated gene silencing 2*ENSMUSG0000003364421
Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*ENSMUSG0000002942321
Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*ENSMUSG0000003691219


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0010586 miRNA metabolic process IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IMP


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002227 Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*  / complex
 ENSMUSG00000025571 Tnrc6c / trinucleotide repeat containing 6C / Q9HCJ0*  / complex
 ENSMUSG00000047888 Q8BKI2 / Tnrc6b / trinucleotide repeat containing 6b / Q9UPQ9*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex






 

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